Applications for Circulating Cell-Free DNA in Oral Squamous Cell Carcinoma: A Non-Invasive Approach for Detecting Structural Variants, Fusions, and Oncoviruses

• Published in: Cancers Vol. 17; no. 12; p. 1901
• Main Authors: Bhattacharya, Mahua, Yaniv, Dan, D’Souza, Dylan P., Yosefof, Eyal, Tzelnick, Sharon, Detroja, Rajesh, Wax, Tal, Levy-Barda, Adva, Baum, Gideon, Mizrachi, Aviram, Bachar, Gideon, Frenkel Morgenstern, Milana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.06.2025; MDPI
• Subjects: Analysis; Biopsy; Cancer; Cancer therapies; Care and treatment; Chemotherapy; Chimeras; Chromosome 1; Chromosome 2; Chromosome 8; Chromosome deletion; Complications and side effects; Consent; Copy number; Diagnosis; Disease; DNA repair; DNA sequencing; Enteroviruses; Fusion protein; Gene fusion; Gene mutations; Genes; Genetic aspects; Genomics; Health aspects; Human papillomavirus; Invasiveness; Keratinization; Life style; Malignancy; Medical prognosis; Metastasis; Mouth cancer; Mutation; Nucleotide sequencing; Oral carcinoma; Oral squamous cell carcinoma; p53 Protein; Papillomavirus infections; Pathogenesis; Patients; Plasma; Prognosis; Radiation therapy; Risk factors; Sample size; Squamous cell carcinoma; Transfer RNA; tRNA; tRNA Ala; Tumors; Variation; Viruses; Israel; United States > US; OSCC; cfDNA; CNVs; gene fusion; oral cavity cancers; SNVs; liquid biopsy; virus integration

Background: Circulating cell-free DNA (cfDNA) has been widely used as a prognostic marker for different cancers. Objective: In this study, we used 30 cfDNA samples from oral squamous cell carcinoma (OSCC), 199 public OSCC samples, and 192 normal samples to study various correlation factors that coul...