Effects of Adolescent Cannabinoid Self-Administration in Rats on Addiction-Related Behaviors and Working Memory

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 42; no. 5; pp. 989 - 1000
• Main Authors: Kirschmann, Erin K, Pollock, Michael W, Nagarajan, Vidhya, Torregrossa, Mary M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2017
• Subjects: Abstinence; Addictions; Animals; Behavior, Addictive; Benzoxazines - administration & dosage; Cannabinoid Receptor Agonists - administration & dosage; Cannabis sativa; Child development; Cognition & reasoning; Cognitive ability; Drug dosages; Drug-Seeking Behavior - drug effects; GABA Plasma Membrane Transport Proteins - metabolism; Laboratory animals; Male; Marijuana; Memory; Memory, Short-Term - drug effects; Morpholines - administration & dosage; Naphthalenes - administration & dosage; Original; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Protein Subunits - metabolism; Rats, Sprague-Dawley; Receptors, GABA-B - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Self Administration; Tetrahydrocannabinol; THC; United States > US; Pittsburgh Pennsylvania

Use of marijuana (Cannabis sativa) often begins in adolescence, and heavy adolescent marijuana use is often associated with impaired cognitive function in adulthood. However, clinical reports of long-lasting cognitive deficits, particularly in subjects who discontinue use in adulthood, are mixed. Mo...