Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure

Acute-on-chronic liver failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of ACLF, liver damage leads to the failure of other organs and is associated with increased short-term mortality. Optimal medical management of pa...

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Published inJournal of clinical medicine Vol. 13; no. 2; p. 506
Main Authors Saner, Fuat H, Raptis, Dimitri A, Alghamdi, Saad A, Malagó, Massimo M, Broering, Dieter C, Bezinover, Dmitri
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.01.2024
Subjects
Alcohol
Analysis
Bacterial infections
Care and treatment
cirrhosis
Complications and side effects
Consortia
Critical care medicine
Cytokines
Development and progression
Failure
hemodynamic disorder
hemostasis disorder
ICU treatment
infection
Infections
Inflammation
Intensive care
Liver cirrhosis
Liver diseases
Liver failure
Medical prognosis
Methods
Mortality
Patients
Sepsis
Saudi Arabia
ICU treatment
infection
hemostasis disorder
hemodynamic disorder
cirrhosis
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Abstract Acute-on-chronic liver failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of ACLF, liver damage leads to the failure of other organs and is associated with increased short-term mortality. Optimal medical management of patients with ACLF requires implementing complex treatment strategies, often in an intensive care unit (ICU). Failure of organs other than the liver distinguishes ACLF from other critical illnesses. Although there is growing evidence supporting the current approach to ACLF management, the mortality associated with this condition remains unacceptably high. In this review, we discuss considerations for ICU care of patients with ACLF and highlight areas for further research.
AbstractList Acute-on-chronic liver failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of ACLF, liver damage leads to the failure of other organs and is associated with increased short-term mortality. Optimal medical management of patients with ACLF requires implementing complex treatment strategies, often in an intensive care unit (ICU). Failure of organs other than the liver distinguishes ACLF from other critical illnesses. Although there is growing evidence supporting the current approach to ACLF management, the mortality associated with this condition remains unacceptably high. In this review, we discuss considerations for ICU care of patients with ACLF and highlight areas for further research.
Audience Academic
Author Bezinover, Dmitri
Raptis, Dimitri A
Saner, Fuat H
Malagó, Massimo M
Broering, Dieter C
Alghamdi, Saad A
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Snippet Acute-on-chronic liver failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of...
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SubjectTerms Alcohol
Analysis
Bacterial infections
Care and treatment
cirrhosis
Complications and side effects
Consortia
Critical care medicine
Cytokines
Development and progression
Failure
hemodynamic disorder
hemostasis disorder
ICU treatment
infection
Infections
Inflammation
Intensive care
Liver cirrhosis
Liver diseases
Liver failure
Medical prognosis
Methods
Mortality
Patients
Sepsis
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Title Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure
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Volume 13
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