Statin Use Reduces Decline in Lung Function: VA Normative Aging Study

• Published in: American journal of respiratory and critical care medicine Vol. 176; no. 8; pp. 742 - 747
• Main Authors: Alexeeff, Stacey E, Litonjua, Augusto A, Sparrow, David, Vokonas, Pantel S, Schwartz, Joel
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.10.2007; American Lung Association; American Thoracic Society
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma; B. Chronic Obstructive Pulmonary Disease; Biological and medical sciences; Bronchitis; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, asthma; Emergency and intensive respiratory care; Forced Expiratory Volume - drug effects; Forced Expiratory Volume - physiology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Inflammation; Intensive care medicine; Longitudinal Studies; Male; Medical sciences; Medical screening; Middle Aged; Mortality; Oxidative stress; Pneumology; Questionnaires; Smoking; Smoking - epidemiology; Smoking - physiopathology; Statins; Vital Capacity - drug effects; Vital Capacity - physiology; Intensive care; Senescence; FVC; Lung function; statins; Tobacco smoking; smoking; Statin derivative; FEV1; Resuscitation; Antilipemic agent

Decreased lung function has been linked to increased inflammation and oxidative stress. Statins have demonstrated antiinflammatory and antioxidant properties. We investigated the effect of statin use on decline in lung function in the elderly, and whether smoking modified this effect. Our study popu...