Effect of exercise training on chromogranin A and relationship to N-ANP and inflammatory cytokines in patients with chronic heart failure
Abstract Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise training influence the elevated CgA levels in CHF patients. Plasma CgA was determined at baseline and at peak exercise before and after 1...
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| Published in | International journal of cardiology Vol. 127; no. 1; pp. 117 - 120 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ireland Ltd
23.06.2008
Elsevier Science |
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| Abstract | Abstract Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise training influence the elevated CgA levels in CHF patients. Plasma CgA was determined at baseline and at peak exercise before and after 12 weeks of training in 25 men (mean age 67 ± 8 years) with CHF (NYHA functional class II and III). Plasma Chromogranin A (CgA) was significantly elevated in CHF, however without change after the 12 week exercise period. A positive correlation was obtained for CgA versus N-ANP and CgA versus TNFα for the patients with poor survival, indicating that in these patients the elevated plasma CgA was more closely connected to the myocardial release of natriuretic peptides and the inflammatory response than to activation of the sympathoadrenergic system. |
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| AbstractList | Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise training influence the elevated CgA levels in CHF patients. Plasma CgA was determined at baseline and at peak exercise before and after 12 weeks of training in 25 men (mean age 67+/-8 years) with CHF (NYHA functional class II and III). Plasma Chromogranin A (CgA) was significantly elevated in CHF, however without change after the 12 week exercise period. A positive correlation was obtained for CgA versus N-ANP and CgA versus TNFalpha for the patients with poor survival, indicating that in these patients the elevated plasma CgA was more closely connected to the myocardial release of natriuretic peptides and the inflammatory response than to activation of the sympathoadrenergic system. Abstract Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise training influence the elevated CgA levels in CHF patients. Plasma CgA was determined at baseline and at peak exercise before and after 12 weeks of training in 25 men (mean age 67 ± 8 years) with CHF (NYHA functional class II and III). Plasma Chromogranin A (CgA) was significantly elevated in CHF, however without change after the 12 week exercise period. A positive correlation was obtained for CgA versus N-ANP and CgA versus TNFα for the patients with poor survival, indicating that in these patients the elevated plasma CgA was more closely connected to the myocardial release of natriuretic peptides and the inflammatory response than to activation of the sympathoadrenergic system. Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise training influence the elevated CgA levels in CHF patients. Plasma CgA was determined at baseline and at peak exercise before and after 12 weeks of training in 25 men (mean age 67 ± 8 years) with CHF (NYHA functional class II and III). Plasma Chromogranin A (CgA) was significantly elevated in CHF, however without change after the 12 week exercise period. A positive correlation was obtained for CgA versus N-ANP and CgA versus TNFα for the patients with poor survival, indicating that in these patients the elevated plasma CgA was more closely connected to the myocardial release of natriuretic peptides and the inflammatory response than to activation of the sympathoadrenergic system. |
| Author | Kvaløy, Jan T Larsen, Alf Inge Helle, Karen B Dickstein, Kenneth Christensen, Monika Aarsland, Torbjørn |
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| Cites_doi | 10.1056/NEJM198409273111303 10.1177/38.6.2139887 10.1016/j.regpep.2005.11.003 10.1007/BF02942379 10.1016/j.ygcen.2003.12.012 10.1016/0735-1097(92)90167-L 10.1056/NEJM198706043162301 10.1111/j.1748-1716.1994.tb09779.x 10.1074/jbc.275.15.10745 10.1016/S0167-0115(02)00004-6 10.1016/S0002-9343(02)01425-0 10.1161/01.CIR.84.6.2346 10.1093/clinchem/35.8.1631 10.1038/sj.bjc.6690013 10.1056/NEJM200105313442201 10.1016/S0002-9149(01)01859-8 10.1016/j.ejheart.2004.04.012 10.1096/fj.03-0922fje 10.1053/euhj.2001.2977 |
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| Keywords | Physical exercise Chromogranin A N-ANP TNFα. IL-6 Chronic heart failure NYHA class II and III IL-8 Human Heart failure Cytokine Cardiovascular disease Inflammation Phlebology Interleukin 6 Chronic Heart disease Exercise tolerance test Circulatory system Cardiology Tumor necrosis factor α Interleukin 8 |
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| References | Packer (bib1) 1992; 20 Steiner, Weiler, Ludescher, Schmid, Winkler (bib7) 1990; 38 Helle (bib6) 2004; 79 Lugardon, Raffner, Goumon (bib21) 2000; 275 Brekke, Osol, Helle (bib9) 2002; 105 Sullivan, Grosch, Lawless, O'Connor (bib18) 1992; 161 Blois, Holmsen, Martino, Corti, Metz-Boutigue, Helle (bib11) 2006; 134 Larsen, Aukrust, Aarsland (bib15) 2001; 88 Ceconi, Ferrari, Bachetti (bib13) 2002; 23 Cohn, Levine, Olivari (bib2) 1984; 311 Ferrero, Scabini, Magni (bib20) 2004; 18 Goetze, Rehfeld, Videbaek, Friis-Hansen, Kastrup (bib5) 2005; 7 Corti, Mannarino, Mazza, Angelone, Longhi, Tota (bib10) 2004; 136 Helle, Angeletti (bib8) 1994; 152 Omland, Dickstein, Syversen (bib14) 2003; 114 Packer, Coats, Fowler (bib4) 2001; 344 Ferrero, Scabini, Magni (bib12) 2004; 18 (bib3) 1991; 316 O'Connor, Pandlan, Carlton, Cervenka, Hslao (bib17) 1989; 35 Rogers, Tyce, Weinshilboum, O'Connor, Bailey, Bove (bib19) 1991; 84 Degorce, Goumon, Jaquemart (bib16) 1999; 79 Larsen (10.1016/j.ijcard.2007.04.012_bib15) 2001; 88 Corti (10.1016/j.ijcard.2007.04.012_bib10) 2004; 136 Cohn (10.1016/j.ijcard.2007.04.012_bib2) 1984; 311 Blois (10.1016/j.ijcard.2007.04.012_bib11) 2006; 134 (10.1016/j.ijcard.2007.04.012_bib3) 1991; 316 Helle (10.1016/j.ijcard.2007.04.012_bib8) 1994; 152 Packer (10.1016/j.ijcard.2007.04.012_bib4) 2001; 344 Omland (10.1016/j.ijcard.2007.04.012_bib14) 2003; 114 Ceconi (10.1016/j.ijcard.2007.04.012_bib13) 2002; 23 Steiner (10.1016/j.ijcard.2007.04.012_bib7) 1990; 38 Brekke (10.1016/j.ijcard.2007.04.012_bib9) 2002; 105 Sullivan (10.1016/j.ijcard.2007.04.012_bib18) 1992; 161 Goetze (10.1016/j.ijcard.2007.04.012_bib5) 2005; 7 Rogers (10.1016/j.ijcard.2007.04.012_bib19) 1991; 84 Lugardon (10.1016/j.ijcard.2007.04.012_bib21) 2000; 275 O'Connor (10.1016/j.ijcard.2007.04.012_bib17) 1989; 35 Helle (10.1016/j.ijcard.2007.04.012_bib6) 2004; 79 Ferrero (10.1016/j.ijcard.2007.04.012_bib20) 2004; 18 Packer (10.1016/j.ijcard.2007.04.012_bib1) 1992; 20 Degorce (10.1016/j.ijcard.2007.04.012_bib16) 1999; 79 Ferrero (10.1016/j.ijcard.2007.04.012_bib12) 2004; 18 |
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| Snippet | Abstract Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether... Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise... |
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| SubjectTerms | Aged Atrial Natriuretic Factor - blood Biological and medical sciences Cardiology. Vascular system Cardiovascular Chromogranin A Chromogranin A - blood Chronic Disease Chronic heart failure Cytokines - blood Exercise Therapy Heart Heart Failure - blood Heart Failure - physiopathology Heart Failure - therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans IL-8 Male Medical sciences N-ANP NYHA class II and III Physical exercise Prognosis TNFα. IL-6 |
| Title | Effect of exercise training on chromogranin A and relationship to N-ANP and inflammatory cytokines in patients with chronic heart failure |
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