A critical review of histopathological findings associated with endocrine and non-endocrine hepatic toxicity in fish models

• Published in: Aquatic toxicology Vol. 197; pp. 60 - 78
• Main Authors: Wolf, Jeffrey C., Wheeler, James R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2018
• Subjects: active ingredients; adults; Androgens - toxicity; Animals; aromatase; Data credibility; Endocrine disruption; Endocrine Disruptors - toxicity; enzyme inhibition; estrogens; Estrogens - toxicity; females; Fish; Fishes - metabolism; hazard characterization; Hepatotoxicity; Histopathology; Liver; Liver - drug effects; Liver - pathology; males; toxicity; Water Pollutants, Chemical - toxicity; DMN; MEOGRT; Liver; MDHT; TCDD; Vtg; Endocrine disruption; DEN; Histopathology; Data credibility; EAS; PAH; Fish; HC; MTC; Hepatotoxicity; MOA

Although frequently examined as a target organ for non-endocrine toxicity, histopathological evaluation of the liver is becoming a routine component of endocrine disruption studies that utilize various fish species as test subjects. However, the interpretation of microscopic liver findings can be ch...