Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment

• Published in: Physiological genomics Vol. 8; no. 2; pp. 123 - 129
• Main Authors: Provoost, Abraham P, Shiozawa, Masahide, Van Dokkum, Richard P. E, Jacob, Howard J
• Format: Journal Article
• Language: English
• Published: United States Am Physiological Soc 28.02.2002
• Subjects: Animals; Animals, Congenic; Blood Pressure - genetics; Crosses, Genetic; Female; Gene Transfer Techniques; Genetic Markers - genetics; Genetic Predisposition to Disease - genetics; Kidney Failure, Chronic - genetics; Kidney Failure, Chronic - physiopathology; Kidney Function Tests; Kidney Glomerulus - physiopathology; Male; Rats; Rats, Inbred ACI; Systole - genetics; Transgenes - genetics

1 Department of Pediatric Surgery, Erasmus University, 3000 DR Rotterdam, The Netherlands 2 Laboratory for Genetics Research, Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 The genetically hypertensive fawn-hooded (FHH/Eur) rat is characterized by the early presen...