Design and evaluation of biological gate circuits and their therapeutic applications in a model of multidrug resistant cancers - Soheili, Naeimeh; Eshghi, Mohammad; Emadi-Baygi, Modjtaba; Mirzaei, Seyed Abbas; Heidari, Razieh; Hosseinzadeh, Mehdi (Biotechnology letters, 2020)
Keywords: Antibiotics; Antineoplastic Agents - pharmacology; Applied Microbiology; Biochemistry; Biomedical and Life Sciences; Biotechnology; Butyric Acid - pharmacology; Cancer; Cancer therapies; cancer therapy; Circuit design; Circuits; Doxycycline; Doxycycline - pharmacology; Drug resistance; Drug Resistance, Multiple - genetics; Drug Resistance, Neoplasm - genetics; Gates (circuits); Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Genetic Vectors - genetics; Humans; Lentivirus - genetics; Life Sciences; MCF-7 Cells; MDR1 protein; Microbiology; Models, Biological; Multidrug resistance; Multidrug resistant organisms; multiple drug resistance; Original Research Paper; P-Glycoprotein; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Sodium; Sodium butyrate; synthetic biology; Synthetic Biology - methods; synthetic genes; Therapeutic applications; Transcription; transcription (genetics); Synthetic biology; Biological gate; NOT-IF gate; shRNA; Cancer therapy; Multidrug resistance