Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study
Background: Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT’s effect on the temporal profile of ANS activity at rest is yet to be described. Aims...
Saved in:
| Published in | Journal of psychopharmacology (Oxford) Vol. 37; no. 6; pp. 566 - 576 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London, England
SAGE Publications
01.06.2023
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0269-8811 1461-7285 |
| DOI | 10.1177/02698811231158233 |
Cover
Loading…
| Abstract | Background:
Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT’s effect on the temporal profile of ANS activity at rest is yet to be described.
Aims:
We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions.
Methods:
We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest.
Results:
In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65–100 min, and as an exploratory finding, an increased HF-HRV in the 80–85 min time window.
Conclusions:
We suggest there is a role of OT in PNS regulation that may be consistent with OT’s currently theorized role in the facilitation of alertness and approach behavior. |
|---|---|
| AbstractList | Background:
Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT’s effect on the temporal profile of ANS activity at rest is yet to be described.
Aims:
We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions.
Methods:
We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest.
Results:
In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65–100 min, and as an exploratory finding, an increased HF-HRV in the 80–85 min time window.
Conclusions:
We suggest there is a role of OT in PNS regulation that may be consistent with OT’s currently theorized role in the facilitation of alertness and approach behavior. Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT's effect on the temporal profile of ANS activity at rest is yet to be described. We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions. We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest. In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65-100 min, and as an exploratory finding, an increased HF-HRV in the 80-85 min time window. We suggest there is a role of OT in PNS regulation that may be consistent with OT's currently theorized role in the facilitation of alertness and approach behavior. |
| Author | Cosme, Gonçalo Rosa, Pedro J. Arriaga, Patrícia Mehta, Mitul A. Prata, Diana |
| Author_xml | – sequence: 1 givenname: Gonçalo orcidid: 0000-0003-4324-8770 surname: Cosme fullname: Cosme, Gonçalo – sequence: 2 givenname: Patrícia surname: Arriaga fullname: Arriaga, Patrícia – sequence: 3 givenname: Pedro J. surname: Rosa fullname: Rosa, Pedro J. – sequence: 4 givenname: Mitul A. surname: Mehta fullname: Mehta, Mitul A. – sequence: 5 givenname: Diana orcidid: 0000-0002-4051-022X surname: Prata fullname: Prata, Diana email: diana.prata@kcl.ac.uk |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36891949$$D View this record in MEDLINE/PubMed |
| BookMark | eNplkMtOwzAQRS0EoqXwAWyQfyDFju04ZlchXlIlNmUdTW2nTZXYke0gsufDSVVYsRrpzLmj0b1C5847i9AtJUtKpbwneaHKktKcUSrKnLEzNKe8oJnMS3GO5sd9dhRm6CrGAyG04IW4RDNWlIoqruboe2O73gdocR983bQW-xo3LgVwECfqv8bkdeMmhtPe4v3QgcMwJO9812jsbPj0Q8RxjMl2GBIONqYHvHLYtlan4DUE0_hdgH4_YnAG90PftK3vbAojjmkw4zW6qKGN9uZ3LtDH89Pm8TVbv7-8Pa7WmeZcpExtJS8pB05EAbbeUs1qoaSxpeWSgpqYIEQxo6CWyohcCqYVaJKDyacoW6C7091-2HbWVH1oOghj9VfHJCxPQoSdrQ5-CG76p6KkOvZd_eub_QBG_XUH |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023 |
| Copyright_xml | – notice: The Author(s) 2023 |
| DBID | AFRWT CGR CUY CVF ECM EIF NPM |
| DOI | 10.1177/02698811231158233 |
| DatabaseName | Sage Journals GOLD Open Access 2024 Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: AFRWT name: Sage Journals GOLD Open Access url: http://journals.sagepub.com/ sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Psychology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1461-7285 |
| EndPage | 576 |
| ExternalDocumentID | 36891949 10.1177_02698811231158233 |
| Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: European Commission Seventh Framework Programme Marie Curie Career Integration Grant grantid: FP7-PEOPLE-2013-CIG-631952 – fundername: Fundação para a Ciência e a Tecnologia grantid: IF/00787/2014 funderid: https://doi.org/10.13039/501100001871 – fundername: Fundação para a Ciência e a Tecnologia grantid: UIDB/00645/2020 funderid: https://doi.org/10.13039/501100001871 – fundername: Fundação para a Ciência e a Tecnologia grantid: LISBOA-01-0145-FEDER-030907 funderid: https://doi.org/10.13039/501100001871 – fundername: fundação bial grantid: Ref. 292/16 funderid: https://doi.org/10.13039/501100005032 – fundername: Fundação para a Ciência e a Tecnologia grantid: DSAIPA/DS/0065/2018 funderid: https://doi.org/10.13039/501100001871 – fundername: Fundação para a Ciência e a Tecnologia grantid: SFRH/BD/148088/2019 funderid: https://doi.org/10.13039/501100001871 |
| GroupedDBID | --- -TM -~X .2E .2F .2G .2J .2N 01A 0R~ 1~K 29L 31R 31S 31U 31X 31Y 31Z 4.4 53G 54M 5GY 5VS 6PF 85S AABMB AABOD AACKU AACMV AACTG AADUE AAEWN AAGGD AAGLT AAGMC AAJIQ AAJOX AAJPV AAKGS AANSI AAPEO AAQDB AAQXH AAQXI AARDL AARIX AATAA AATBZ AAUAS AAWTL AAXOT AAYTG AAZBJ ABAWC ABAWP ABCCA ABCJG ABDWY ABEIX ABFWQ ABHKI ABHQH ABIDT ABIVO ABJIS ABJNI ABJZC ABKRH ABLUO ABNCE ABPGX ABPNF ABQKF ABQXT ABRHV ABUJY ABVFX ABVVC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFS ACGZU ACJER ACJTF ACLFY ACLHI ACLZU ACNXM ACOFE ACOXC ACPRK ACROE ACRPL ACSIQ ACUAV ACUIR ACXKE ACXMB ADBBV ADDLC ADEBD ADEIA ADMPF ADNBR ADNMO ADNON ADRRZ ADSTG ADTBJ ADUKL ADVBO ADYCS ADZYD ADZZY AECGH AECVZ AEDTQ AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEWDL AEWHI AEXFG AEXNY AFEET AFKBI AFKRG AFMOU AFQAA AFRAH AFRWT AFUIA AFVCE AFWMB AGHKR AGKLV AGNHF AGPXR AGQPQ AGWFA AGWNL AHDMH AHHFK AIGRN AJABX AJEFB AJMMQ AJSCY AJUZI AJXAJ AJXGE ALKWR ALMA_UNASSIGNED_HOLDINGS AMCVQ ANDLU ARTOV ASPBG AUTPY AUVAJ AVWKF AYAKG AZFZN B3H B8M B8O B8R B8Z B93 B94 BBRGL BDDNI BKIIM BKSCU BPACV BSEHC BWJAD BYIEH C45 CAG CBRKF CDWPY CFDXU COF CORYS CQQTX CS3 CUTAK DB0 DC- DC0 DD- DD0 DE- DF0 DO- DOPDO DU5 DV7 DV9 D~Y EBS EJD EMOBN F5P FEDTE FHBDP GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION H13 HF~ HVGLF HZ~ IAO IEA IHR INH INR IVC J8X K.F K.J N9A O9- OVD P.B P2P PQQKQ Q1R Q7K Q7L Q7R Q7U Q7X Q82 Q83 RIG ROL S01 SASJQ SAUOL SBI SCNPE SDB SFB SFC SFK SFT SGA SGO SGP SGR SGV SGX SGZ SHG SNB SPJ SPP SPQ SPV SQCSI STM TEORI UPT YQT ZONMY ZPPRI ZRKOI ZSSAH ZY4 AAEJI AAPII AJGYC AJVBE CGR CUY CVF ECM EIF NPM |
| ID | FETCH-LOGICAL-c445t-9b74814a4056aefb1c3f597de8e471a9aef50093d9af79d52753c9ac02ad27483 |
| IEDL.DBID | AFRWT |
| ISSN | 0269-8811 |
| IngestDate | Mon Jul 21 05:38:08 EDT 2025 Tue Jun 17 22:27:59 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Electrocardiography resting state neuropeptide pharmacodynamics pupil unrest |
| Language | English |
| License | This article is distributed under the terms of the Creative Commons Attribution 4.0 Lficense (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c445t-9b74814a4056aefb1c3f597de8e471a9aef50093d9af79d52753c9ac02ad27483 |
| ORCID | 0000-0003-4324-8770 0000-0002-4051-022X |
| OpenAccessLink | https://journals.sagepub.com/doi/full/10.1177/02698811231158233?utm_source=summon&utm_medium=discovery-provider |
| PMID | 36891949 |
| PageCount | 11 |
| ParticipantIDs | pubmed_primary_36891949 sage_journals_10_1177_02698811231158233 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-06-01 |
| PublicationDateYYYYMMDD | 2023-06-01 |
| PublicationDate_xml | – month: 06 year: 2023 text: 2023-06-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London, England |
| PublicationPlace_xml | – name: London, England – name: United States |
| PublicationTitle | Journal of psychopharmacology (Oxford) |
| PublicationTitleAlternate | J Psychopharmacol |
| PublicationYear | 2023 |
| Publisher | SAGE Publications |
| Publisher_xml | – name: SAGE Publications |
| References | Caffier, Erdmann, Ullsperger 2003; 89 Brown, Cardoso, Ellenbogen 2016; 43 Lipponen, Tarvainen 2019; 43 Shilling, Feifel 2016; 30 Kemp, Quintana, Kuhnert 2012; 7 Schumann, Kietzer, Ebel 2020; 14 Borland, Rilling, Frantz 2019; 44 Acharya, Joseph, Kannathal 2006; 44 Mahmoud, Kaufmann, Djupesland 2018; 44 Quintana, Lischke, Grace 2021; 26 Shamay-Tsoory, Abu-Akel 2016; 79 Rilling, DeMarco, Hackett 2012; 37 Harari-Dahan, Bernstein 2014; 47 Prehn, Kazzer, Lischke 2013; 50 Baethge, Vahle-Hinz, Rigotti 2019; 105 Beffara, Bret, Vermeulen 2016; 164 Chrousos, Gold 1992; 267 Park, Thayer 2014; 5 Schleicher, Galley, Briest 2008; 51 Lischke, Lemke, Neubert 2017; 7 Wang, Toor, Gautam 2011; 52 Cacciotti-Saija, Quintana, Alvares 2018; 269 Salonia, Nappi, Pontillo 2005; 47 Sabe, Zhao, Crippa 2021; 24 Gutkowska, Jankowski, Antunes-Rodrigues 2014; 47 Yang, Simmons, Matthews 2007; 428 Richman, Moorman 2000; 278 Rothman 1990; 1 Dreu 2012; 61 Bates, Mächler, Bolker 2015; 67 Cosme, Tavares, Nobre 2022; 86 Martins, Gabay, Mehta 2020; 9 Hayes, Petrov 2016; 48 Winterton, Westlye, Steen 2021; 5 Lüdtke, Wilhelm, Adler 1998; 38 Krohova, Czippelova, Turianikova 2017; 66 Danker-Hopfe, Kraemer, Dorn 2001; 38 Donets, Dreyer, Vallat 2018 Quintana, Guastella 2020; 24 Cosme, Rosa, Lima 2021; 11 Huang, Huang, Ebstein 2021; 122 Stock, Bremme, Uvnäs-moberg 1991; 6 Evans, Monte, Noble 2014; 1580 Mather, Thayer 2018; 19 Liu, Tao, Yang 2019; 10 Zelenina, Kosilo, da Cruz 2022; 32 Tulppo, Antti, Arto 2005; 112 Alley, Diamond, Lipschitz 2019; 106 Lory, Kadlaskar, McNally Keehn 2020; 11 Jawad, Ahmad, Hashmi 2021; 13 Brysbaert, Stevens 2018; 1 Mitchell, Haynes, Anderson 1981; 12 Averbeck, Bobin, Evans 2012; 42 Leknes, Wessberg, Ellingsen 2013; 8 Marazziti, Baroni, Mucci 2019; 15 Tarvainen, Niskanen, Lipponen 2014; 113 Zhao, Zhang, Wang 2022; 16 Meyer-Lindenberg, Domes, Kirsch 2011; 12 Dodhia, Hosanagar, Fitzgerald 2014; 39 Hershman, Henik, Cohen 2018; 50 Erdozain, Peñagarikano 2020; 10 Lancaster, Goldbeck, Puglia 2018; 13 Saville 1990; 44 Schumann, Andrack, Bär 2017; 79 |
| References_xml | – volume: 26 start-page: 80 year: 2021 end-page: 91 article-title: Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research publication-title: Mol Psychiatry – volume: 278 year: 2000 article-title: Physiological time-series analysis using approximate entropy and sample entropy publication-title: Am J Physiol Heart Circ Physiol – volume: 89 start-page: 319 year: 2003 end-page: 325 article-title: Experimental evaluation of eye-blink parameters as a drowsiness measure publication-title: Eur J Appl Physiol – volume: 16 start-page: 1143 year: 2022 article-title: Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior publication-title: Front Neurosci – volume: 44 start-page: 1031 year: 2006 end-page: 1051 article-title: Heart rate variability: a review publication-title: Med Biol Eng Comput – volume: 79 start-page: 324 year: 2017 end-page: 331 article-title: Differences of sympathetic and parasympathetic modulation in major depression publication-title: Prog Neuro-Psychopharmacol Biol Psychiatry – volume: 112 start-page: 314 year: 2005 end-page: 319 article-title: Physiological background of the loss of fractal heart rate dynamics publication-title: Circulation – volume: 47 start-page: 206 year: 2014 end-page: 214 article-title: The role of oxytocin in cardiovascular regulation publication-title: Braz J Med Biol Res – volume: 7 start-page: e44014 year: 2012 article-title: Oxytocin increases heart rate variability in humans at rest: Implications for social approach-related motivation and capacity for social engagement publication-title: PLoS One – volume: 105 start-page: 506 year: 2019 end-page: 526 article-title: Coworker support and its relationship to allostasis during a workday: a diary study on trajectories of heart rate variability during work publication-title: J Appl Psychol – volume: 24 start-page: 515 year: 2020 end-page: 528 article-title: An allostatic theory of oxytocin publication-title: Trends Cognit Sci – volume: 30 start-page: 193 year: 2016 end-page: 208 article-title: Potential of oxytocin in the treatment of schizophrenia publication-title: CNS Drugs – volume: 79 start-page: 194 year: 2016 end-page: 202 article-title: The social salience hypothesis of oxytocin publication-title: Biol Psychiatry – volume: 66 year: 2017 article-title: Preejection period as a sympathetic activity index: A role of confounding factors publication-title: Physiol Res – volume: 12 start-page: 524 year: 2011 end-page: 538 article-title: Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine publication-title: Nat Rev Neurosci – volume: 10 start-page: 930 year: 2020 article-title: Oxytocin as treatment for social cognition, not there yet publication-title: Front Psychiatry – volume: 47 start-page: 164 year: 2005 end-page: 169 article-title: Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women publication-title: Horm Behav – volume: 113 start-page: 210 year: 2014 end-page: 220 article-title: Kubios HRV – Heart rate variability analysis software publication-title: Comput Methods Programs Biomed – volume: 6 start-page: 1056 year: 1991 end-page: 1062 article-title: Plasma levels of oxytocin during the menstrual cycle, pregnancy and following treatment with HMG publication-title: Hum Reprod – volume: 52 start-page: 4546 year: 2011 end-page: 4550 article-title: Blink frequency and duration during perimetry and their relationship to test-retest threshold variability publication-title: Invest Ophthalmol Visual Sci – volume: 13 start-page: 1155 year: 2018 end-page: 1162 article-title: DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology publication-title: Soc Cognit Affective Neurosci – volume: 106 start-page: 47 year: 2019 end-page: 56 article-title: Associations between oxytocin and cortisol reactivity and recovery in response to psychological stress and sexual arousal publication-title: Psychoneuroendocrinol – volume: 12 start-page: 195 year: 1981 end-page: 200 article-title: Plasma oxytocin concentrations during the menstrual cycle publication-title: Eur J Obstet Gynecol Reprod Biol – volume: 1 start-page: 43 year: 1990 end-page: 46 article-title: No adjustments are needed for multiple comparisons publication-title: Epidemiol – volume: 122 start-page: 18 year: 2021 end-page: 27 article-title: Intranasal oxytocin in the treatment of autism spectrum disorders: A multilevel meta-analysis publication-title: Neurosci Biobehav Rev – volume: 9 start-page: 1 year: 2020 end-page: 19 article-title: Salivary and plasmatic oxytocin are not reliable trait markers of the physiology of the oxytocin system in humans publication-title: eLife – volume: 269 start-page: 293 year: 2018 end-page: 300 article-title: Reduced heart rate variability in a treatment-seeking early psychosis sample publication-title: Psychiatry Res – volume: 44 start-page: 174 year: 1990 article-title: Multiple comparison procedures: The practical solution publication-title: Am Stat – volume: 428 start-page: 109 year: 2007 end-page: 114 article-title: Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects publication-title: Neurosci Lett – volume: 43 start-page: 19 year: 2016 end-page: 27 article-title: A meta-analytic review of the correlation between peripheral oxytocin and cortisol concentrations publication-title: Front Neuroendocrinol – volume: 37 start-page: 447 year: 2012 end-page: 461 article-title: Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men publication-title: Psychoneuroendocrinol – volume: 14 start-page: 178 year: 2020 article-title: Sympathetic and parasympathetic modulation of pupillary unrest publication-title: Front Neurosci – volume: 51 start-page: 982 year: 2008 end-page: 1010 article-title: Blinks and saccades as indicators of fatigue in sleepiness warnings: Looking tired? publication-title: Ergon – volume: 38 start-page: 828 year: 2001 end-page: 835 article-title: Time-of-day variations in different measures of sleepiness (MSLT, pupillography, and SSS) and their interrelations publication-title: Psychophysiol – volume: 164 start-page: 417 year: 2016 end-page: 428 article-title: Resting high frequency heart rate variability selectively predicts cooperative behavior publication-title: Physiol Behav – volume: 7 start-page: 1 year: 2017 end-page: 6 article-title: Inter-individual differences in heart rate variability are associated with inter-individual differences in mind-reading publication-title: Sci Rep – volume: 10 start-page: 217 year: 2019 article-title: Decreased serum oxytocin and increased homocysteine in first-episode schizophrenia patients publication-title: Front Psychiatry – volume: 15 start-page: 58 year: 2019 end-page: 63 article-title: Sex-related differences in plasma oxytocin levels in humans publication-title: Clin Pract Epidemiol Mental Health – volume: 48 start-page: 510 year: 2016 end-page: 527 article-title: Mapping and correcting the influence of gaze position on pupil size measurements publication-title: Behav Res Methods – volume: 43 start-page: 173 year: 2019 end-page: 181 article-title: A robust algorithm for heart rate variability time series artefact correction using novel beat classification publication-title: J Med Eng Technol – volume: 19 start-page: 98 year: 2018 end-page: 104 article-title: How heart rate variability affects emotion regulation brain networks publication-title: Curr Opin Behav Sci – volume: 39 start-page: 2061 year: 2014 end-page: 2069 article-title: Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder publication-title: Neuropsychopharmacol – year: 2018 article-title: pyEntropy – volume: 1 start-page: 1 year: 2018 end-page: 20 article-title: Power analysis and effect size in mixed effects models: A tutorial publication-title: J Cognit – volume: 5 start-page: 278 year: 2014 article-title: From the heart to the mind: cardiac vagal tone modulates top-down and bottom-up visual perception and attention to emotional stimuli publication-title: Front Psychol – volume: 50 start-page: 528 year: 2013 end-page: 537 article-title: Effects of intranasal oxytocin on pupil dilation indicate increased salience of socioaffective stimuli publication-title: Psychophysiol – volume: 42 start-page: 259 year: 2012 end-page: 266 article-title: Emotion recognition and oxytocin in patients with schizophrenia publication-title: Psychol Med – volume: 5 start-page: 9 year: 2021 end-page: 18 article-title: Improving the precision of intranasal oxytocin research publication-title: Nat Hum Behav – volume: 47 start-page: 506 year: 2014 end-page: 519 article-title: A general approach-avoidance hypothesis of Oxytocin: Accounting for social and non-social effects of oxytocin publication-title: Neurosci Biobehav Rev – volume: 44 start-page: 306 year: 2018 end-page: 313 article-title: Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: A randomized controlled pupillometry and fMRI study publication-title: Neuropsychopharmacol – volume: 44 start-page: 97 year: 2019 end-page: 110 article-title: Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis publication-title: Neuropsychopharmacol – volume: 38 start-page: 2889 year: 1998 end-page: 2896 article-title: Mathematical procedures in data recording and processing of pupillary fatigue waves publication-title: Vision Res – volume: 11 start-page: 3733 year: 2021 article-title: Pupil dilation reflects the authenticity of received nonverbal vocalizations publication-title: Sci Rep – volume: 11 start-page: 4183 year: 2020 end-page: 4190 article-title: Brief report: Reduced heart rate variability in children with autism spectrum disorder publication-title: J Autism Dev Disord – volume: 1580 start-page: 69 year: 2014 end-page: 77 article-title: Intranasal oxytocin effects on social cognition: A critique publication-title: Brain Res – volume: 13 year: 2021 article-title: Role of oxytocin in the pathogenesis and modulation of borderline personality disorder: A review publication-title: Cureus – volume: 267 start-page: 1244 year: 1992 end-page: 1252 article-title: The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis publication-title: JAMA J Am Med Assoc – volume: 32 start-page: 3110 year: 2022 end-page: 3126 article-title: Temporal dynamics of intranasal oxytocin in human brain electrophysiology publication-title: Cereb Cortex – volume: 24 start-page: 601 year: 2021 end-page: 614 article-title: Intranasal oxytocin for negative symptoms of schizophrenia: Systematic review, meta-analysis, and dose-response meta-Analysis of randomized controlled trials publication-title: Int J Neuropsychopharmacol – volume: 67 start-page: 1 year: 2015 end-page: 48 article-title: Fitting linear mixed-effects models using lme4 publication-title: J Stat Software – volume: 8 start-page: 741 year: 2013 end-page: 749 article-title: Oxytocin enhances pupil dilation and sensitivity to ‘hidden’ emotional expressions publication-title: Soc Cognit Affective Neurosci – volume: 86 start-page: 597 year: 2022 end-page: 616 article-title: Cultural differences in vocal emotion recognition: a behavioural and skin conductance study in Portugal and Guinea-Bissau publication-title: Psychol Res – volume: 61 start-page: 419 year: 2012 end-page: 428 article-title: Oxytocin modulates cooperation within and competition between groups: An integrative review and research agenda publication-title: Horm Behav – volume: 50 start-page: 107 year: 2018 end-page: 114 article-title: A novel blink detection method based on pupillometry noise publication-title: Behav Res Methods |
| SSID | ssj0016465 |
| Score | 2.3793929 |
| Snippet | Background:
Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the... Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic... |
| SourceID | pubmed sage |
| SourceType | Index Database Publisher |
| StartPage | 566 |
| SubjectTerms | Administration, Intranasal Autonomic Nervous System Electrocardiography Heart Rate Humans Male Oxytocin - pharmacology Social Behavior |
| Title | Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study |
| URI | https://journals.sagepub.com/doi/full/10.1177/02698811231158233 https://www.ncbi.nlm.nih.gov/pubmed/36891949 |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3NS-QwFH_oePGyrLoffvIOohe7bps0k3iRQXaQBWWQkfVWMmkCwkw7OC1s7_7h5jWtyrIHr6GQkveS9_37ARyzxLhcec9NxC6NuMvTSDkVR8YI7Zw3oUNH08g3t-L6nv9-SB_WoOxnYboTXP2gtir_R-1jTbebstHnXZHx3AcOSkrvKhBWjEwYu6yrRRbS3T2rBq1QfbpeUGnbUENkE_XjbeuwQWRMfAAbo_Hdn-lr4UHwln2SNohoh64Q-t9N3xmtd11grWEaf4ZPnUeJo6ACW7Bmi204mQRI6uYMp28TVqszPMHJG1h1sw2bry9gswPP0wBUNceOyhtLh4-U_i30yq-Wf5vKC7Pwa-gdR2wJ_lDXVRhuxsI_PGW9wgAPjbpCYv64wFGBHd2OadtfA0o26iLHZb18nM_Lha2eGmyxbr_A_fjX9Oo66mgaIsN5WkVqNuQy5tq7fkJbN4sNcz5Mya203vIR-rdLKXGSK-2GKk8THyEZpc3PROc-JpbsKwyKsrDfARMn0hlBxmnhuNRWaZGaIc8ZY9YpJ3fhWzjxbBmwODImpIoVV7twSiLIev3J4h7H_F-p7X34y33YJHL50Bh2AIPqqbaH3gWpZked2hzB-u3k5gUnwNs3 |
| linkProvider | SAGE Publications |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LS8QwEB50PehFfL91DqIXK7ZJs4m3RVzWJyIVvZVsmsDC2i5uF-zdH27S1FXEg9fQlJJJZ75JZr4P4JBEymTCIjcWmjigJosDYUQYKMWkMTaEto3rRr67Z70nev0SvzRVla4XplnB8akrq7JfVDvr6d_tmJIiJji3KMHRxPCIkFmYozZq8RbMdbqPz8n0DoHRWkjSTQjcjOZO88-X_Ig_Pwq66hjTXYLFBhxix1tzGWZ0vgJHD55dujrB5LtZanyCR_jwzTtdrcDC1JlVq_CReM6pITaq3FgYHLiT3FyO7WjxXpXWLrkdQ4sBsdbqQzkpfZ8y5taHFJMxeqZnlCU6EY9z7OTYKOeoupLVE16jzDMcTUaD4bB41eVbhTVt7Ro8dS-Ti17QKC4EitK4DES_TXlIpUVxTGrTDxUxNuPINNc2iDkibxO7M5BMSNMWWRzZZEcJqc4imdn0lpN1aOVFrjcBI8PivmN_k8xQLrWQLFZtmhFCtBGGb8GGX_F05Gk1UsK4CAUVW3DsTJB-bYU0_KIk_2217X8_eQDzveTuNr29ur_ZgQWnGe_rvXahVb5N9J5FFmV_v9lCn6pAx5M |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEB7aDZRcSpq-0qTtHEp6iZvYkmWpt6Xtkr7CUjY0N6OVNBDY2kvWC_E9PzySpTwoPfQqLGM08rzn-wDescKQVd5zEzmVGSdbZopUnhkjNJE3oRWFaeSfJ-L4lH87K89Swi3MwqQTXH0IbVX-iwZlHf7upaXDVGM89HGDktJ7CgEqRhaMPYQNzit-NIKN8eTX79ltHUHwgUwybMjCjlTX_OdL7tmge01dg52ZbMHj5CDiOEr0CTxwzTbsTyPCdH-As7uBqdUB7uP0Dnu634bNW4XWP4WrWcSdWmBi5saW8Dxkcxu98qvtZd952TR-Db0fiANfH-p1F2eVsfF6pF2vMKI9o-4wEHl8xHGDiT3HDN2sEfQadWNxuV6eLxbtH9dd9DhA1z6D08mX2afjLLEuZIbzssvUvOIy59p7ckI7mueGkY86rJPOG7IA5k1lyINYpalStix8wGOUNkeFtj7Elew5jJq2cS8BCxLlPCDAaUFcaqe0KE3FLWPMkSK5Ay_iidfLCK1RMyFVrrjagfdBBPXNdajzG1jyv6X26r-ffAuPpp8n9Y-vJ993YTPQxseWrz0YdRdr99o7F938TbpB17gRyKM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Temporal+profile+of+intranasal+oxytocin+in+the+human+autonomic+nervous+system+at+rest%3A+An+electrocardiography+and+pupillometry+study&rft.jtitle=Journal+of+psychopharmacology+%28Oxford%29&rft.au=Cosme%2C+Gon%C3%A7alo&rft.au=Arriaga%2C+Patr%C3%ADcia&rft.au=Rosa%2C+Pedro+J.&rft.au=Mehta%2C+Mitul+A.&rft.date=2023-06-01&rft.pub=SAGE+Publications&rft.issn=0269-8811&rft.eissn=1461-7285&rft.volume=37&rft.issue=6&rft.spage=566&rft.epage=576&rft_id=info:doi/10.1177%2F02698811231158233&rft.externalDocID=10.1177_02698811231158233 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0269-8811&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0269-8811&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0269-8811&client=summon |