Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencing

• Published in: Frontiers in immunology Vol. 13; p. 1053819
• Main Authors: Wei, Peiru, Dong, Mingyou, Bi, Yin, Chen, Saiqiong, Huang, Weiyu, Li, Ting, Liu, Bo, Fu, Xiaoqian, Yang, Yihua
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 11.11.2022
• Subjects: bulk RNA-sequencing; Immunology; macrophage; maternal fetal interface; recurrent miscarriage; single-cell RNA-sequencing

Recurrent miscarriage (RM) is a chronic, heterogeneous autoimmune disease that has serious social and personal consequences. No valid and reliable diagnostic markers or therapeutic targets for RM have been identified. Macrophages impact the innate immune system and can be used as diagnostic and prog...