Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis

The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways. In this review, we focus on TRPA1 (transient receptor potential ankyrin 1), an ion channel in this family that exists in the cell membrane and sh...

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Published inFrontiers in pharmacology Vol. 13; p. 1014041
Main Authors Wei, Yicheng, Cai, Jialuo, Zhu, Ruiqiu, Xu, Ke, Li, Hongchang, Li, Jianxin
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 06.10.2022
Subjects
fibrosis
inflammation
Pharmacology
TGF-β
TRPA1
TRPA1 antagonists
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Abstract The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways. In this review, we focus on TRPA1 (transient receptor potential ankyrin 1), an ion channel in this family that exists in the cell membrane and shows a different function from other TRP channels. TRPA1 usually has a special activation effect that can induce cation ions, especially calcium ions, to flow into activated cells. In this paper, we review the role of TRPA1 in fibroblasts. To clarify the relationship between fibroblasts and TRPA1, we have also paid special attention to the interactions between TRPA1 and inflammatory factors leading to fibroblast activation. TRPA1 has different functions in the fibrosis process in different organs, and there have also been interesting discussions of the mechanism of TRPA1 in fibroblasts. Therefore, this review aims to describe the function of TRP channels in controlling fibrosis through fibroblasts in different organ inflammatory and immune-mediated diseases. We attempt to prove that TRPA1 is a target for fibrosis. In fact, some clinical trials have already proven that TRPA1 is a potential adjuvant therapy for treating fibrosis.
AbstractList The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways. In this review, we focus on TRPA1 (transient receptor potential ankyrin 1), an ion channel in this family that exists in the cell membrane and shows a different function from other TRP channels. TRPA1 usually has a special activation effect that can induce cation ions, especially calcium ions, to flow into activated cells. In this paper, we review the role of TRPA1 in fibroblasts. To clarify the relationship between fibroblasts and TRPA1, we have also paid special attention to the interactions between TRPA1 and inflammatory factors leading to fibroblast activation. TRPA1 has different functions in the fibrosis process in different organs, and there have also been interesting discussions of the mechanism of TRPA1 in fibroblasts. Therefore, this review aims to describe the function of TRP channels in controlling fibrosis through fibroblasts in different organ inflammatory and immune-mediated diseases. We attempt to prove that TRPA1 is a target for fibrosis. In fact, some clinical trials have already proven that TRPA1 is a potential adjuvant therapy for treating fibrosis.
Author Li, Hongchang
Li, Jianxin
Cai, Jialuo
Xu, Ke
Zhu, Ruiqiu
Wei, Yicheng
AuthorAffiliation 6 Wenzhou Institute of Shanghai University , Wenzhou , China
5 Musculoskeletal Organoid Research Center , Institute of Translational Medicine , Shanghai University , Shanghai , China
1 Third Affiliated Hospital of Shanghai University/Wenzhou People’s Hospital , Wenzhou , China
2 Shanghai Putuo Central School of Clinical Medicine , Anhui Medical University , Hefei , Anhui , China
7 Department of General Surgery , Institute of Fudan–Minhang Academic Health System , Minhang Hospital , Fudan University , Shanghai , China
3 Interventional Cancer Institute of Chinese Integrative Medicine , Putuo Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai , China
4 Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism , Shanghai Key Laboratory of New Drug Design , School of Pharmacy , East China University of Science and Technology , Shanghai , China
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– name: 7 Department of General Surgery , Institute of Fudan–Minhang Academic Health System , Minhang Hospital , Fudan University , Shanghai , China
– name: 6 Wenzhou Institute of Shanghai University , Wenzhou , China
– name: 1 Third Affiliated Hospital of Shanghai University/Wenzhou People’s Hospital , Wenzhou , China
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These authors have contributed equally to this work
Edited by: Gerard Bannenberg, Global Organization for EPA and DHA Omega-3s (GOED), United States
Reviewed by: Ari-Pekka Koivisto, Orion Corporation, Finland
Tzong-Shyuan Lee, National Taiwan University, Taiwan
This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology
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Snippet The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways. In...
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SubjectTerms fibrosis
inflammation
Pharmacology
TGF-β
TRPA1
TRPA1 antagonists
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Title Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis
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