Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter

• Published in: Epigenetics Vol. 6; no. 10; pp. 1236 - 1241
• Main Authors: Martin-Trujillo, Alex, Iglesias-Platas, Isabel, Coto, Eliecer, Corral-Juan, Marc, San Nicolás, Hector, Corral, Jordi, Volpini, Victor, Matilla-Dueñas, Antoni, Monk, David
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.10.2011
• Subjects: Binding; Biology; Bioscience; Calcium; Cancer; Cell; Chromosomes, Human, Pair 4; CpG Islands; Cycle; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Genotype; Humans; Landes; Organogenesis; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Proteins; TRPC Cation Channels - genetics

A fundamental challenge in the post-genomics era is to understand how genetic variants can influence phenotypic variability and disease. Recent observations from a number of studies have highlighted a mechanism by which common genetic polymorphisms can influence DNA methylation, a major epigenetic s...