Head and Neck Squamous Cell Carcinomas Do Not Express EGFRvIII

• Published in: International journal of radiation oncology, biology, physics Vol. 90; no. 2; pp. 454 - 462
• Main Authors: Melchers, Lieuwe J., MD, PhD, Clausen, Martijn J.A.M., MSc, Mastik, Mirjam F., BSc, Slagter-Menkema, Lorian, BSc, Langendijk, Johannes A., MD, PhD, van der Laan, Bernard F.A.M., MD, PhD, van der Wal, Jacqueline E., MD, DDS, PhD, van der Vegt, Bert, MD, PhD, Roodenburg, Jan L.N., DDS, PhD, Schuuring, Ed, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2014
• Subjects: Adult; Aged; Aged, 80 and over; ANIMAL TISSUES; ANTIBODIES; Carcinoma, Squamous Cell - metabolism; CARCINOMAS; Cohort Studies; COMPARATIVE EVALUATIONS; ErbB Receptors - analysis; ErbB Receptors - genetics; Female; GLIOMAS; GROWTH FACTORS; HEAD; Head and Neck Neoplasms - metabolism; Hematology, Oncology and Palliative Medicine; Humans; Immunohistochemistry; Male; Middle Aged; Mutation; MUTATIONS; NECK; Neoplasm Proteins - analysis; Neoplasm Proteins - genetics; POLYMERASE CHAIN REACTION; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; RECEPTORS; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA - analysis; Squamous Cell Carcinoma of Head and Neck; Tissue Array Analysis - methods; TRANSCRIPTION

Purpose To assess the prevalence of EGFRvIII, a specific variant of EGFR (epidermal growth factor receptor), in 3 well-defined cohorts of head and neck squamous cell carcinoma (HNSCC). Methods and Materials Immunohistochemistry for the specific detection of EGFRvIII using the L8A4 antibody was optim...