The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus

• Published in: Metabolism, clinical and experimental Vol. 53; no. 1; pp. 66 - 72
• Main Authors: Michno, Anna, Skibowska, Anna, Raszeja-Specht, Anna, Ćwikowska, Justyna, Szutowicz, Andrzej
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2004; Elsevier
• Subjects: Acetyl Coenzyme A - blood; Adult; ATP Citrate (pro-S)-Lyase - antagonists & inhibitors; ATP Citrate (pro-S)-Lyase - blood; Biological and medical sciences; Blood Glucose - analysis; Blood Platelets - physiology; Citrates - pharmacology; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzyme Inhibitors - pharmacology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fructosamine - blood; Glycated Hemoglobin A - analysis; Humans; Lactones - pharmacology; Malondialdehyde - blood; Medical sciences; Middle Aged; Platelet Activation - drug effects; Platelet Aggregation - drug effects; Pyruvate Dehydrogenase Complex - blood; Thrombin - pharmacology; Endocrinopathy; Enzyme; Diabetes mellitus; Platelet function; Citrate; Acetyl coenzyme A; Lyases; Metabolism; ATP; Blood

Diabetes is known to increase blood platelet activity. Activities of pyruvate dehydrogenase (PDH), adenosine triphosphate (ATP)-citrate lyase (ATPCL), acetyl-coenzyme A (acetyl-CoA) content, malonyl dialdehyde (MDA), synthesis, and platelet aggregation in resting conditions and after activation with...