Cataract Formation in a Child Receiving Dabrafenib and Trametinib Therapy

• Published in: Journal of pediatric ophthalmology and strabismus Vol. 61; no. 5; pp. e47 - e49
• Main Authors: Botros, Elaine, Bradfield, Yasmin, Pytel, Nicholas
• Format: Journal Article
• Language: English
• Published: Thorofare, NJ SLACK Incorporated 01.09.2024; Slack, Inc; SLACK INCORPORATED
• Subjects: Antimitotic agents; Antineoplastic agents; Brain cancer; Cancer; Care and treatment; Cataract; Cataract - chemically induced; Cataract - diagnosis; Cataracts; Cell cycle; Chemotherapy; Child; Combination therapy; Eye examinations; Female; Gene mutations; Genetic aspects; Glioma; Humans; Imidazoles - adverse effects; Inhibitor drugs; Kinases; Lung cancer; Magnetic resonance imaging; Melanoma; Metastasis; Mitogens; Mutation; Ophthalmology; Oximes - adverse effects; Patients; Pediatrics; Proto-Oncogene Proteins B-raf - antagonists & inhibitors; Pyridones - adverse effects; Pyrimidinones - adverse effects; Toxicity; Vision disorders in children; Visual acuity; United States > US; Wisconsin

The authors report a case of bilateral cataract in a 9-year-old girl after being treated with a combination of the targeted therapy drugs dabrafenib and trametinib. Although adverse effects have been reported with this treatment, this report is the first documented case of cataract as a complication...