Cataract Formation in a Child Receiving Dabrafenib and Trametinib Therapy

The authors report a case of bilateral cataract in a 9-year-old girl after being treated with a combination of the targeted therapy drugs dabrafenib and trametinib. Although adverse effects have been reported with this treatment, this report is the first documented case of cataract as a complication...

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Bibliographic Details
Published inJournal of pediatric ophthalmology and strabismus Vol. 61; no. 5; pp. e47 - e49
Main Authors Botros, Elaine, Bradfield, Yasmin, Pytel, Nicholas
Format Journal Article
LanguageEnglish
Published Thorofare, NJ SLACK Incorporated 01.09.2024
Slack, Inc
SLACK INCORPORATED
Subjects
Antimitotic agents
Antineoplastic agents
Brain cancer
Cancer
Care and treatment
Cataract
Cataract - chemically induced
Cataract - diagnosis
Cataracts
Cell cycle
Chemotherapy
Child
Combination therapy
Eye examinations
Female
Gene mutations
Genetic aspects
Glioma
Humans
Imidazoles - adverse effects
Inhibitor drugs
Kinases
Lung cancer
Magnetic resonance imaging
Melanoma
Metastasis
Mitogens
Mutation
Ophthalmology
Oximes - adverse effects
Patients
Pediatrics
Proto-Oncogene Proteins B-raf - antagonists & inhibitors
Pyridones - adverse effects
Pyrimidinones - adverse effects
Toxicity
Vision disorders in children
Visual acuity
United States > US
Wisconsin
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Summary:The authors report a case of bilateral cataract in a 9-year-old girl after being treated with a combination of the targeted therapy drugs dabrafenib and trametinib. Although adverse effects have been reported with this treatment, this report is the first documented case of cataract as a complication. [J Pediatr Ophthalmol Strabismus. 2024;61(5):e47–e49.]
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ISSN:0191-3913
1938-2405
1938-2405
DOI:10.3928/01913913-20240722-01