Densitometric Thin-Layer Chromatographic Determination of Artemisinin and its Lipophilic Derivatives, Artemether and Arteether

• Published in: Journal of chromatographic science Vol. 41; no. 7; pp. 359 - 366
• Main Authors: Gabriels, M., Plaizier-Vercammen, J. A.
• Format: Journal Article
• Language: English
• Published: Niles, IL Oxford University Press 01.08.2003; Preston Publications
• Subjects: Analysis; Artemisinins - analysis; Biological and medical sciences; Chromatography, Thin Layer - methods; Densitometry - methods; General pharmacology; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes - analysis; Endoperoxide; Antimalarial; Terpenoid; Chemical analysis; Soaking; Artemisinin; Lactone; Tetracyclic compound; Derivatization; Oxygen heterocycle; Acidic solution; Acetal; Antiprotozoal agent; Thin layer chromatography; Peracetal; Sesquiterpenes; Parasiticid; Dosage form; Artemether; Hard capsule; Densitometry; Detection; Organic peroxide; Quantitative analysis

A thin-layer chromatograpy (TLC) method is developed to analyze artemisinin (AT) and its derivatives, artemether (AM) and arteether (AE), using a silica-gel plate with a mobile phase containing pure chloroform. After development, all products are visualized after dipping in a 4-methoxybenzaldehyde d...