Degree of stemness predicts micro-environmental response and clinical outcomes of diffuse large B-cell lymphoma and identifies a potential targeted therapy

• Published in: Frontiers in immunology Vol. 13; p. 1012242
• Main Authors: Hu, Fang, Li, Huan, Li, Lei, Gale, Robert Peter, Song, Yuanbin, Chen, Shuiqin, Liang, Yang
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 08.11.2022
• Subjects: dequalinium chloride; diffuse large B-cell lymphoma; Immunology; single-sample gene set enrichment analysis; stem cells; targeted therapy; weighted gene co-expression network analysis

Some cells within a diffuse large B-cell lymphoma (DLBCL) have the genotype of a stem cell, the proportion of which is termed degree of stemness . We interrogated correlations between the degree of stemness with immune and stromal cell scores and clinical outcomes in persons with DLBCL. We evaluated...