Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Abstract The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses. Some of these processes can contribute to cancer progression and ne...

Full description

Saved in:
Bibliographic Details
Published inCellular & molecular biology letters Vol. 27; no. 1; p. 60
Main Authors Zalpoor, Hamidreza, Nabi-Afjadi, Mohsen, Forghaniesfidvajani, Razieh, Tavakol, Chanour, Farahighasreaboonasr, Faranak, Pakizeh, Farid, Dana, Vahid Ghobadi, Seif, Farhad
Format Journal Article
LanguageEnglish
Published London BioMed Central 26.07.2022
BMC
Subjects
Cancers
JAK–STAT inhibitor
Neurodegenerative diseases
Quercetin
Review Letter
Solid tumors
Online AccessGet full text

Cover

Abstract Abstract The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses. Some of these processes can contribute to cancer progression and neurodegeneration. Owing to the complexity of this pathway and its potential crosstalk with alternative pathways, monotherapy as targeted therapy has usually limited long-term efficacy. Currently, the majority of JAK–STAT-targeting drugs are still at preclinical stages. Meanwhile, a variety of plant polyphenols, especially quercetin, exert their inhibitory effects on the JAK–STAT pathway through known and unknown mechanisms. Quercetin has shown prominent inhibitory effects on the JAK–STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases. This review discusses the pharmacological effects of quercetin on the JAK–STAT signaling pathway in solid tumors and neurodegenerative diseases.
AbstractList The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses. Some of these processes can contribute to cancer progression and neurodegeneration. Owing to the complexity of this pathway and its potential crosstalk with alternative pathways, monotherapy as targeted therapy has usually limited long-term efficacy. Currently, the majority of JAK-STAT-targeting drugs are still at preclinical stages. Meanwhile, a variety of plant polyphenols, especially quercetin, exert their inhibitory effects on the JAK-STAT pathway through known and unknown mechanisms. Quercetin has shown prominent inhibitory effects on the JAK-STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases. This review discusses the pharmacological effects of quercetin on the JAK-STAT signaling pathway in solid tumors and neurodegenerative diseases.
Abstract The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses. Some of these processes can contribute to cancer progression and neurodegeneration. Owing to the complexity of this pathway and its potential crosstalk with alternative pathways, monotherapy as targeted therapy has usually limited long-term efficacy. Currently, the majority of JAK–STAT-targeting drugs are still at preclinical stages. Meanwhile, a variety of plant polyphenols, especially quercetin, exert their inhibitory effects on the JAK–STAT pathway through known and unknown mechanisms. Quercetin has shown prominent inhibitory effects on the JAK–STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases. This review discusses the pharmacological effects of quercetin on the JAK–STAT signaling pathway in solid tumors and neurodegenerative diseases.
Abstract The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses. Some of these processes can contribute to cancer progression and neurodegeneration. Owing to the complexity of this pathway and its potential crosstalk with alternative pathways, monotherapy as targeted therapy has usually limited long-term efficacy. Currently, the majority of JAK–STAT-targeting drugs are still at preclinical stages. Meanwhile, a variety of plant polyphenols, especially quercetin, exert their inhibitory effects on the JAK–STAT pathway through known and unknown mechanisms. Quercetin has shown prominent inhibitory effects on the JAK–STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases. This review discusses the pharmacological effects of quercetin on the JAK–STAT signaling pathway in solid tumors and neurodegenerative diseases.
ArticleNumber 60
Author Pakizeh, Farid
Dana, Vahid Ghobadi
Zalpoor, Hamidreza
Farahighasreaboonasr, Faranak
Tavakol, Chanour
Seif, Farhad
Nabi-Afjadi, Mohsen
Forghaniesfidvajani, Razieh
Author_xml – sequence: 1
  givenname: Hamidreza
  surname: Zalpoor
  fullname: Zalpoor, Hamidreza
– sequence: 2
  givenname: Mohsen
  orcidid: 0000-0001-8243-1530
  surname: Nabi-Afjadi
  fullname: Nabi-Afjadi, Mohsen
– sequence: 3
  givenname: Razieh
  surname: Forghaniesfidvajani
  fullname: Forghaniesfidvajani, Razieh
– sequence: 4
  givenname: Chanour
  surname: Tavakol
  fullname: Tavakol, Chanour
– sequence: 5
  givenname: Faranak
  surname: Farahighasreaboonasr
  fullname: Farahighasreaboonasr, Faranak
– sequence: 6
  givenname: Farid
  surname: Pakizeh
  fullname: Pakizeh, Farid
– sequence: 7
  givenname: Vahid Ghobadi
  surname: Dana
  fullname: Dana, Vahid Ghobadi
– sequence: 8
  givenname: Farhad
  orcidid: 0000-0003-1275-2157
  surname: Seif
  fullname: Seif, Farhad
BookMark eNpVkcluFDEQhi0URBZ4AU595NLELu8ckEYRS0IkhBjOlpeaiaOe9mB3R-LGO_CGPAmdTISUk636y1-p_J2So7GMSMhrRt8yZtR5Y0xJ01OAnlIuZc-fkROmjO0Zt3C03AXI3jDJj8lpa7eUAhWCviDHXBrDKbATkr7NWCNOeex863x3tfry9_ef7-vVusvjTQ55KvXdUt-XCccp-6GrZcAl61oZcuqmeVfq8nBM3YhzLQm3OGL1U77DLuWGvmF7SZ5v_NDw1eN5Rn58_LC--Nxff_10ebG67qMQcuo13RgWIKKgG9AgbAoxBaORWStF4BGMhKQZ1ZobpQMEo5SSKkhhEkbFz8jlgZuKv3X7mne-_nLFZ_dQKHXrfJ1yHNCB8DYsf8WRWmE8NxB1YEDBmI1WyS6s9wfWfg47THHZvvrhCfRpMuYbty13znLQXN0D3jwCavk5Y5vcLreIw-BHLHNzoKwEu_iApRUOrbGW1ipu_o9h1N2rdgfVblHtHlQ7zv8BWnqdBA
CitedBy_id crossref_primary_10_1007_s10528_024_10758_w
crossref_primary_10_1016_j_ejphar_2024_176490
crossref_primary_10_1016_j_matdes_2023_111731
crossref_primary_10_1007_s00432_022_04431_1
crossref_primary_10_1016_j_biopha_2023_115973
crossref_primary_10_1016_j_jep_2024_118442
crossref_primary_10_1155_2022_7838583
crossref_primary_10_1007_s00210_023_02782_1
crossref_primary_10_2147_CCID_S459070
crossref_primary_10_15789_1563_0625_IPO_2655
crossref_primary_10_1016_j_molstruc_2023_136430
crossref_primary_10_1007_s40995_024_01660_6
crossref_primary_10_1016_j_ntm_2024_100030
crossref_primary_10_1007_s10528_023_10490_x
crossref_primary_10_1016_j_resmic_2023_104091
crossref_primary_10_1016_j_biopha_2023_116016
crossref_primary_10_3390_antiox12071418
crossref_primary_10_1016_j_heliyon_2024_e25058
crossref_primary_10_1007_s13577_023_00996_2
crossref_primary_10_1016_j_npep_2023_102352
crossref_primary_10_1016_j_jtcme_2024_04_009
crossref_primary_10_1007_s00210_024_03191_8
crossref_primary_10_3390_pharmaceutics15020712
crossref_primary_10_1016_j_ejmech_2024_116203
crossref_primary_10_1016_j_jddst_2024_105418
Cites_doi 10.1016/S0014-827X(01)01111-9
10.1002/ptr.6155
10.1038/mp.2008.105
10.3390/biom10010059
10.1186/s11658-021-00301-9
10.1016/j.ejphar.2008.03.008
10.1016/j.yexcr.2012.02.017
10.3390/biomedicines9121916
10.1016/j.lfs.2021.119369
10.1002/ptr.7258
10.1166/jbn.2013.1596
10.1016/0031-6989(85)90041-4
10.3831/KPI.2015.18.002
10.1016/j.biopha.2018.02.125
10.1186/s11658-022-00311-1
10.1002/mnfr.201300362
10.1186/s11658-021-00247-y
10.1111/j.1753-4887.2010.00301.x
10.4155/fmc-2017-0118
10.1016/j.msard.2022.103754
10.1186/s12885-020-07749-6
10.1186/s13578-020-00397-0
10.1007/s00018-017-2520-2
10.1007/s13258-021-01116-w
10.1002/ijc.25516
10.1007/s10495-016-1334-2
10.3390/medicina55090526
10.2147/OTT.S136821
10.1016/j.ijpharm.2020.119830
10.1016/j.jnutbio.2016.12.011
10.2174/1871520619666190705150214
10.1002/jcp.26238
10.2147/OTT.S136840
10.1016/j.jneuroim.2021.577758
10.1172/JCI0215650
10.1186/s12943-017-0589-8
10.1023/B:JOCI.0000040925.55682.a5
10.1021/jf9811065
10.1016/j.intimp.2021.107562
10.1007/s10565-020-09562-0
10.1155/2012/928643
10.1186/s11658-021-00260-1
10.1002/ptr.5061
10.1186/s11658-021-00292-7
10.1007/s12010-013-0561-z
10.1007/s12029-020-00386-z
10.1016/j.clim.2016.09.014
10.1016/j.bcp.2006.08.001
10.2174/187152009787313855
10.2217/hep-2020-0001
10.1385/1-59259-889-7:127
10.1186/s12964-017-0177-y
10.1097/PPO.0b013e318212dd3d
10.1002/jbt.21821
10.1016/j.ejphar.2006.11.014
10.4161/jkst.22925
10.1016/j.freeradbiomed.2004.08.002
10.3390/molecules200611524
10.1039/C9FO01168D
10.1080/01635581.2014.864418
10.3322/caac.20141
10.1002/mnfr.201400558
10.1111/acel.12344
10.1016/j.jnutbio.2014.11.017
10.1038/nrneurol.2012.168
10.1016/S0304-3940(97)00797-0
10.1159/000508247
10.1158/0008-5472.CAN-20-2066
10.1016/j.colsurfb.2019.03.037
10.1093/jn/136.11.2715
10.1016/j.cytogfr.2007.06.003
10.1080/01635581.2013.810291
10.1042/bj3580547
10.1186/s11658-020-00216-x
10.1371/journal.pone.0057735
10.1186/s11658-022-00332-w
10.1097/MCO.0b013e32831394b8
10.1248/bpb.b12-01004
10.1016/j.neuint.2015.07.002
10.1124/pr.108.000562
10.1007/s11926-020-00931-6
10.1186/s11658-022-00321-z
10.1002/biof.1605
10.1017/jns.2016.41
10.1007/s12640-019-00120-z
10.1016/j.taap.2013.10.003
10.1523/JNEUROSCI.3516-14.2015
10.1177/00912700122010366
10.1186/s11658-020-00229-6
10.1186/s12948-021-00161-w
10.3390/nu8030167
10.1142/S0192415X21500361
10.3390/cancers12071971
10.1007/s11033-009-9501-y
10.18632/oncotarget.22556
10.1002/cam4.2388
10.1007/s00535-008-2184-7
10.1016/j.addr.2004.02.014
10.1200/JCO.2005.05.2308
10.3390/life12040591
10.1016/j.lfs.2019.03.055
10.1007/s13577-022-00697-2
10.3892/ijo.2015.3160
10.1111/jfbc.13374
10.1002/mc.22318
10.1080/10717544.2016.1176087
10.1007/s12029-019-00290-1
10.3322/caac.21492
ContentType Journal Article
Copyright The Author(s) 2022
Copyright_xml – notice: The Author(s) 2022
DBID AAYXX
CITATION
7X8
5PM
DOA
DOI 10.1186/s11658-022-00355-3
DatabaseName CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1689-1392
EndPage 60
ExternalDocumentID oai_doaj_org_article_24a9b1683e0948a382c7b120288f76d9
10_1186_s11658_022_00355_3
GroupedDBID ---
-56
-5G
-BR
.86
.VR
06D
0R~
0VY
29B
2JY
2~H
30V
4.4
408
53G
5GY
67N
67Z
6NX
6S1
7X7
88E
8AO
8FI
8FJ
8TC
8UJ
95.
95~
AAFWJ
AAJSJ
AAKDD
AAQCX
AASQH
AAXMT
AAYXX
ABAQN
ABFKT
ABMNI
ABUWG
ACGFS
ACOMO
ACPRK
ACRMQ
ACZBO
ADBBV
ADGYE
ADINQ
ADOZN
ADUKV
AENEX
AFBAA
AFBBN
AFCXV
AFKRA
AFPKN
AFWTZ
AHBYD
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AOIJS
BA0
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
C24
C6C
CCPQU
CITATION
CS3
DU5
E3Z
EBLON
EBS
EMOBN
F5P
FRP
FYUFA
G-Y
G-Z
GQ6
GQ7
GROUPED_DOAJ
GX1
HCIFZ
HF~
HG6
HLICF
HMCUK
HMJXF
HYE
IAO
IJ-
IXC
IXE
IY9
IZQ
I~X
I~Z
KDC
KOV
M1P
M7P
MA-
N9A
OAM
OK1
PF0
PIMPY
PSQYO
Q2X
QOS
R9I
RBZ
RNS
ROL
RPM
RPX
RSV
S27
S3A
S3B
SBL
SDH
SHX
SOJ
SZN
T13
TR2
TSK
TSV
TUC
U2A
UKHRP
VC2
WK8
XSB
Y2W
~A9
7X8
5PM
ID FETCH-LOGICAL-c445t-70f81b2ce40f27249dbcdb87e19954b3c2852d710773867b2b866656b548dec63
IEDL.DBID RPM
ISSN 1425-8153
IngestDate Tue Oct 22 15:16:11 EDT 2024
Tue Sep 17 21:05:30 EDT 2024
Fri Oct 25 23:23:46 EDT 2024
Thu Sep 12 17:27:13 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c445t-70f81b2ce40f27249dbcdb87e19954b3c2852d710773867b2b866656b548dec63
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0001-8243-1530
0000-0003-1275-2157
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327369/
PMID 35883021
PQID 2695294402
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_24a9b1683e0948a382c7b120288f76d9
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9327369
proquest_miscellaneous_2695294402
crossref_primary_10_1186_s11658_022_00355_3
PublicationCentury 2000
PublicationDate 20220726
PublicationDateYYYYMMDD 2022-07-26
PublicationDate_xml – month: 7
  year: 2022
  text: 20220726
  day: 26
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Cellular & molecular biology letters
PublicationYear 2022
Publisher BioMed Central
BMC
Publisher_xml – name: BioMed Central
– name: BMC
References AW Boots (355_CR16) 2008; 585
S Xu (355_CR83) 2020; 25
D Yu (355_CR77) 2017; 10
A Rauf (355_CR90) 2018; 32
M Karami Fath (355_CR41) 2022; 27
AG Hovanessian (355_CR34) 2007; 18
H Zalpoor (355_CR43) 2022; 27
A Ghosh (355_CR99) 2013; 8
Y Zhu (355_CR121) 2015; 14
H Zalpoor (355_CR39) 2022; 909
M Vinayak (355_CR27) 2019; 19
W Li (355_CR75) 2021; 26
G Muthian (355_CR105) 2004; 24
E Sohrabi (355_CR67) 2021; 43
T Xia (355_CR45) 2021; 35
355_CR98
SD Buckingham (355_CR115) 2009; 61
C Lv (355_CR107) 2012; 2012
D Wróbel-Biedrawa (355_CR106) 2022; 12
Y Kitamura (355_CR113) 1997; 237
H Tiwari (355_CR38) 2019; 178
Y Song (355_CR62) 2021; 56
E Zaplatic (355_CR117) 2019; 224
ML Casella (355_CR4) 2014; 58
L Brannon-Peppas (355_CR72) 2004; 56
J Li (355_CR74) 2022; 27
J-Y Zhang (355_CR66) 2015; 20
R Naeimi (355_CR104) 2018; 101
KV Hirpara (355_CR24) 2009; 9
K Sak (355_CR23) 2014; 66
M Granato (355_CR94) 2017; 41
L Senggunprai (355_CR96) 2014; 28
L Arzuman (355_CR95) 2014; 34
T Chiba (355_CR118) 2009; 14
355_CR69
AN Panche (355_CR17) 2016; 5
D Iacopetta (355_CR28) 2017; 9
HI Kim (355_CR48) 2021; 49
O Mirmosayyeb (355_CR102) 2022; 89
T Nishino (355_CR112) 2021; 26
J Michaud-Levesque (355_CR44) 2012; 318
CS Nicolas (355_CR97) 2013; 2
CC Nwaeburu (355_CR80) 2017; 16
Y Qin (355_CR65) 2012; 28
KA Youdim (355_CR42) 2004; 37
F Kamangar (355_CR84) 2006; 24
A Srinivasan (355_CR73) 2016; 55
P Khanna (355_CR60) 2015; 47
H Khan (355_CR111) 2020; 10
N Raftery (355_CR36) 2017; 74
F Bray (355_CR53) 2018; 68
F Dajas (355_CR122) 2015; 89
SC Bischoff (355_CR3) 2008; 11
M Barbarisi (355_CR50) 2018; 233
H Lassmann (355_CR100) 2012; 8
E Cengiz (355_CR71) 2010; 37
A Mukherjee (355_CR87) 2015; 18
H Zalpoor (355_CR7) 2022; 8
H Zalpoor (355_CR40) 2022; 35
Y Qiao (355_CR58) 2020; 589
E Tavana (355_CR1) 2020; 46
Y Li (355_CR119) 2016; 8
V Fodale (355_CR70) 2011; 17
J Ferlay (355_CR81) 2010; 127
R González-Segovia (355_CR64) 2008; 43
DR Ferry (355_CR25) 1996; 2
M Liao (355_CR85) 2020; 25
A Davoodvandi (355_CR79) 2020; 44
P Wang (355_CR89) 2015; 59
B Pang (355_CR78) 2019; 10
A Alqahtani (355_CR55) 2019; 55
T Guardia (355_CR21) 2001; 56
M Moslemi (355_CR68) 2021; 21
S Sharma (355_CR109) 2020; 37
V Davra (355_CR47) 2021; 81
V García-Mediavilla (355_CR19) 2007; 557
LB Haim (355_CR114) 2015; 35
P Wang (355_CR88) 2015; 26
AB Granado-Serrano (355_CR5) 2006; 136
H Schroeter (355_CR116) 2001; 358
Y Liu (355_CR93) 2017; 22
355_CR57
P Asgharian (355_CR32) 2021; 2021
P Lakhanpal (355_CR18) 2007; 2
SR Soofiyani (355_CR33) 2021; 2021
N-A Lashgari (355_CR110) 2021; 89
A Vafadar (355_CR15) 2020; 10
E Yang (355_CR63) 2021; 9
M Nabi-Afjadi (355_CR35) 2021; 19
Y-R Liao (355_CR46) 2020; 5
J Jakubowicz-Gil (355_CR52) 2013; 273
HE El-Horany (355_CR108) 2016; 30
E Pozsgai (355_CR51) 2013; 65
Z Yan (355_CR14) 2018; 189
Q Long (355_CR92) 2013; 9
I Igbe (355_CR6) 2017; 8
S Beheshtirouy (355_CR61) 2021; 52
Y Liu (355_CR49) 2017; 10
F Seif (355_CR8) 2017; 15
E Mirzazadeh (355_CR103) 2019; 22
AJ Brooks (355_CR13) 2020
E Puerta (355_CR120) 2017; 517
N Joshi (355_CR10) 2021; 275
P Bayat (355_CR101) 2021; 95
EP Simard (355_CR76) 2012; 62
SH Häkkinen (355_CR2) 1999; 47
X Guan (355_CR30) 2016; 23
EU Graefe (355_CR26) 2001; 41
Y Liu (355_CR82) 2021; 26
DE Levy (355_CR11) 2002; 109
A Safi (355_CR12) 2021; 10
S Eyvazi (355_CR59) 2020; 51
F Seif (355_CR9) 2020; 181
M Mamani-Matsuda (355_CR20) 2006; 72
Y Guo (355_CR31) 2021; 37
L Wu (355_CR56) 2019; 8
A Bindoli (355_CR29) 1985; 17
V Reddy (355_CR37) 2020; 22
JJ Hin Tang (355_CR54) 2020; 7
H Youn (355_CR86) 2013; 36
AJ Vargas (355_CR22) 2010; 68
P Maleki Dana (355_CR91) 2022; 27
References_xml – volume: 56
  start-page: 683
  issue: 9
  year: 2001
  ident: 355_CR21
  publication-title: Farmaco.
  doi: 10.1016/S0014-827X(01)01111-9
  contributor:
    fullname: T Guardia
– volume: 32
  start-page: 2109
  issue: 11
  year: 2018
  ident: 355_CR90
  publication-title: Phytother Res
  doi: 10.1002/ptr.6155
  contributor:
    fullname: A Rauf
– volume: 14
  start-page: 206
  issue: 2
  year: 2009
  ident: 355_CR118
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2008.105
  contributor:
    fullname: T Chiba
– volume: 10
  start-page: 59
  issue: 1
  year: 2020
  ident: 355_CR111
  publication-title: Biomolecules
  doi: 10.3390/biom10010059
  contributor:
    fullname: H Khan
– volume: 27
  start-page: 1
  issue: 1
  year: 2022
  ident: 355_CR91
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-021-00301-9
  contributor:
    fullname: P Maleki Dana
– volume: 585
  start-page: 325
  issue: 2–3
  year: 2008
  ident: 355_CR16
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2008.03.008
  contributor:
    fullname: AW Boots
– volume: 318
  start-page: 925
  issue: 8
  year: 2012
  ident: 355_CR44
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2012.02.017
  contributor:
    fullname: J Michaud-Levesque
– volume: 9
  start-page: 1916
  issue: 12
  year: 2021
  ident: 355_CR63
  publication-title: Biomedicines
  doi: 10.3390/biomedicines9121916
  contributor:
    fullname: E Yang
– volume: 275
  year: 2021
  ident: 355_CR10
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2021.119369
  contributor:
    fullname: N Joshi
– volume: 35
  start-page: 6720
  issue: 12
  year: 2021
  ident: 355_CR45
  publication-title: Phytother Res
  doi: 10.1002/ptr.7258
  contributor:
    fullname: T Xia
– volume: 9
  start-page: 965
  issue: 6
  year: 2013
  ident: 355_CR92
  publication-title: J Biomed Nanotechnol
  doi: 10.1166/jbn.2013.1596
  contributor:
    fullname: Q Long
– volume: 909
  start-page: 1
  year: 2022
  ident: 355_CR39
  publication-title: Hum Cell
  contributor:
    fullname: H Zalpoor
– volume: 17
  start-page: 831
  issue: 9
  year: 1985
  ident: 355_CR29
  publication-title: Pharmacol Res Commun
  doi: 10.1016/0031-6989(85)90041-4
  contributor:
    fullname: A Bindoli
– volume: 18
  start-page: 19
  issue: 1
  year: 2015
  ident: 355_CR87
  publication-title: J Pharmacopuncture
  doi: 10.3831/KPI.2015.18.002
  contributor:
    fullname: A Mukherjee
– volume: 101
  start-page: 485
  year: 2018
  ident: 355_CR104
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2018.02.125
  contributor:
    fullname: R Naeimi
– volume: 10
  start-page: 11
  issue: 1
  year: 2021
  ident: 355_CR12
  publication-title: Int J Mol Cell Med
  contributor:
    fullname: A Safi
– volume: 27
  start-page: 1
  issue: 1
  year: 2022
  ident: 355_CR43
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-022-00311-1
  contributor:
    fullname: H Zalpoor
– volume: 58
  start-page: 289
  issue: 2
  year: 2014
  ident: 355_CR4
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.201300362
  contributor:
    fullname: ML Casella
– volume: 26
  start-page: 1
  issue: 1
  year: 2021
  ident: 355_CR82
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-021-00247-y
  contributor:
    fullname: Y Liu
– volume: 68
  start-page: 418
  issue: 7
  year: 2010
  ident: 355_CR22
  publication-title: Nutr Rev
  doi: 10.1111/j.1753-4887.2010.00301.x
  contributor:
    fullname: AJ Vargas
– volume: 9
  start-page: 2011
  issue: 17
  year: 2017
  ident: 355_CR28
  publication-title: Future Med Chem
  doi: 10.4155/fmc-2017-0118
  contributor:
    fullname: D Iacopetta
– volume: 89
  start-page: 103754
  year: 2022
  ident: 355_CR102
  publication-title: Multiple Sclerosis Relat Disord.
  doi: 10.1016/j.msard.2022.103754
  contributor:
    fullname: O Mirmosayyeb
– volume: 21
  start-page: 1
  issue: 1
  year: 2021
  ident: 355_CR68
  publication-title: BMC Cancer
  doi: 10.1186/s12885-020-07749-6
  contributor:
    fullname: M Moslemi
– volume: 34
  start-page: 5453
  issue: 10
  year: 2014
  ident: 355_CR95
  publication-title: Anticancer Res
  contributor:
    fullname: L Arzuman
– volume: 10
  start-page: 1
  issue: 1
  year: 2020
  ident: 355_CR15
  publication-title: Cell Biosci
  doi: 10.1186/s13578-020-00397-0
  contributor:
    fullname: A Vafadar
– volume: 74
  start-page: 2525
  issue: 14
  year: 2017
  ident: 355_CR36
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-017-2520-2
  contributor:
    fullname: N Raftery
– volume: 43
  start-page: 1065
  issue: 9
  year: 2021
  ident: 355_CR67
  publication-title: Genes Genomics
  doi: 10.1007/s13258-021-01116-w
  contributor:
    fullname: E Sohrabi
– volume: 127
  start-page: 2893
  issue: 12
  year: 2010
  ident: 355_CR81
  publication-title: Int J Cancer
  doi: 10.1002/ijc.25516
  contributor:
    fullname: J Ferlay
– volume: 2021
  start-page: 9
  year: 2021
  ident: 355_CR32
  publication-title: Oxid Med Cell Long
  contributor:
    fullname: P Asgharian
– volume: 22
  start-page: 544
  issue: 4
  year: 2017
  ident: 355_CR93
  publication-title: Apoptosis
  doi: 10.1007/s10495-016-1334-2
  contributor:
    fullname: Y Liu
– volume: 55
  start-page: 526
  issue: 9
  year: 2019
  ident: 355_CR55
  publication-title: Medicina
  doi: 10.3390/medicina55090526
  contributor:
    fullname: A Alqahtani
– volume: 10
  start-page: 4023
  year: 2017
  ident: 355_CR49
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S136821
  contributor:
    fullname: Y Liu
– volume: 589
  year: 2020
  ident: 355_CR58
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2020.119830
  contributor:
    fullname: Y Qiao
– volume: 41
  start-page: 124
  year: 2017
  ident: 355_CR94
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2016.12.011
  contributor:
    fullname: M Granato
– volume: 19
  start-page: 1560
  issue: 13
  year: 2019
  ident: 355_CR27
  publication-title: Anti-Cancer Agents Med Chem
  doi: 10.2174/1871520619666190705150214
  contributor:
    fullname: M Vinayak
– volume: 233
  start-page: 6550
  issue: 10
  year: 2018
  ident: 355_CR50
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.26238
  contributor:
    fullname: M Barbarisi
– volume: 10
  start-page: 4719
  year: 2017
  ident: 355_CR77
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S136840
  contributor:
    fullname: D Yu
– volume: 89
  start-page: 577758
  year: 2021
  ident: 355_CR110
  publication-title: J Neuroimmunol
  doi: 10.1016/j.jneuroim.2021.577758
  contributor:
    fullname: N-A Lashgari
– volume: 109
  start-page: 1143
  issue: 9
  year: 2002
  ident: 355_CR11
  publication-title: J Clin Investig
  doi: 10.1172/JCI0215650
  contributor:
    fullname: DE Levy
– volume: 16
  start-page: 1
  issue: 1
  year: 2017
  ident: 355_CR80
  publication-title: Mol Cancer
  doi: 10.1186/s12943-017-0589-8
  contributor:
    fullname: CC Nwaeburu
– volume: 24
  start-page: 542
  issue: 5
  year: 2004
  ident: 355_CR105
  publication-title: J Clin Immunol
  doi: 10.1023/B:JOCI.0000040925.55682.a5
  contributor:
    fullname: G Muthian
– volume: 47
  start-page: 2274
  issue: 6
  year: 1999
  ident: 355_CR2
  publication-title: J Agric Food Chem
  doi: 10.1021/jf9811065
  contributor:
    fullname: SH Häkkinen
– volume: 95
  year: 2021
  ident: 355_CR101
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2021.107562
  contributor:
    fullname: P Bayat
– volume: 37
  start-page: 479
  issue: 3
  year: 2021
  ident: 355_CR31
  publication-title: Cell Biol Toxicol
  doi: 10.1007/s10565-020-09562-0
  contributor:
    fullname: Y Guo
– volume: 2012
  start-page: 8
  year: 2012
  ident: 355_CR107
  publication-title: Evid-Based Complement Altern Med.
  doi: 10.1155/2012/928643
  contributor:
    fullname: C Lv
– volume: 26
  start-page: 1
  issue: 1
  year: 2021
  ident: 355_CR112
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-021-00260-1
  contributor:
    fullname: T Nishino
– volume: 28
  start-page: 841
  issue: 6
  year: 2014
  ident: 355_CR96
  publication-title: Phytother Res
  doi: 10.1002/ptr.5061
  contributor:
    fullname: L Senggunprai
– volume: 5
  start-page: 31
  issue: 3
  year: 2020
  ident: 355_CR46
  publication-title: J Explor Res Pharmacol
  contributor:
    fullname: Y-R Liao
– volume: 26
  start-page: 1
  issue: 1
  year: 2021
  ident: 355_CR75
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-021-00292-7
  contributor:
    fullname: W Li
– volume: 2
  start-page: 22
  issue: 2
  year: 2007
  ident: 355_CR18
  publication-title: Internet J Med Update
  contributor:
    fullname: P Lakhanpal
– ident: 355_CR57
  doi: 10.1007/s12010-013-0561-z
– volume: 52
  start-page: 207
  issue: 1
  year: 2021
  ident: 355_CR61
  publication-title: J Gastrointest Cancer
  doi: 10.1007/s12029-020-00386-z
  contributor:
    fullname: S Beheshtirouy
– volume: 189
  start-page: 4
  year: 2018
  ident: 355_CR14
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2016.09.014
  contributor:
    fullname: Z Yan
– volume: 72
  start-page: 1304
  issue: 10
  year: 2006
  ident: 355_CR20
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2006.08.001
  contributor:
    fullname: M Mamani-Matsuda
– volume: 9
  start-page: 138
  issue: 2
  year: 2009
  ident: 355_CR24
  publication-title: Anti-Cancer Agents Med Chem
  doi: 10.2174/187152009787313855
  contributor:
    fullname: KV Hirpara
– volume: 7
  start-page: HEP18
  issue: 1
  year: 2020
  ident: 355_CR54
  publication-title: Hepatic Oncol.
  doi: 10.2217/hep-2020-0001
  contributor:
    fullname: JJ Hin Tang
– volume: 517
  start-page: 50
  issue: 1–2
  year: 2017
  ident: 355_CR120
  publication-title: Int J Pharm
  contributor:
    fullname: E Puerta
– ident: 355_CR69
  doi: 10.1385/1-59259-889-7:127
– volume: 15
  start-page: 1
  issue: 1
  year: 2017
  ident: 355_CR8
  publication-title: Cell Commun Signaling
  doi: 10.1186/s12964-017-0177-y
  contributor:
    fullname: F Seif
– volume: 17
  start-page: 89
  issue: 2
  year: 2011
  ident: 355_CR70
  publication-title: Cancer J (Sudbury, Mass)
  doi: 10.1097/PPO.0b013e318212dd3d
  contributor:
    fullname: V Fodale
– volume: 30
  start-page: 360
  issue: 7
  year: 2016
  ident: 355_CR108
  publication-title: J Biochem Mol Toxicol
  doi: 10.1002/jbt.21821
  contributor:
    fullname: HE El-Horany
– volume: 557
  start-page: 221
  issue: 2–3
  year: 2007
  ident: 355_CR19
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2006.11.014
  contributor:
    fullname: V García-Mediavilla
– volume: 2
  issue: 1
  year: 2013
  ident: 355_CR97
  publication-title: JAK-STAT
  doi: 10.4161/jkst.22925
  contributor:
    fullname: CS Nicolas
– volume: 37
  start-page: 1683
  issue: 11
  year: 2004
  ident: 355_CR42
  publication-title: Free Radical Biol Med
  doi: 10.1016/j.freeradbiomed.2004.08.002
  contributor:
    fullname: KA Youdim
– volume: 20
  start-page: 11524
  issue: 6
  year: 2015
  ident: 355_CR66
  publication-title: Molecules
  doi: 10.3390/molecules200611524
  contributor:
    fullname: J-Y Zhang
– volume: 10
  start-page: 5339
  issue: 9
  year: 2019
  ident: 355_CR78
  publication-title: Food Funct
  doi: 10.1039/C9FO01168D
  contributor:
    fullname: B Pang
– volume: 66
  start-page: 177
  issue: 2
  year: 2014
  ident: 355_CR23
  publication-title: Nutr Cancer
  doi: 10.1080/01635581.2014.864418
  contributor:
    fullname: K Sak
– volume: 62
  start-page: 118
  issue: 2
  year: 2012
  ident: 355_CR76
  publication-title: Cancer J Clin
  doi: 10.3322/caac.20141
  contributor:
    fullname: EP Simard
– volume: 28
  start-page: 12
  issue: 1
  year: 2012
  ident: 355_CR65
  publication-title: Chin J Cell Mol Immunol.
  contributor:
    fullname: Y Qin
– volume: 59
  start-page: 250
  issue: 2
  year: 2015
  ident: 355_CR89
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.201400558
  contributor:
    fullname: P Wang
– volume: 22
  start-page: 1
  issue: 1
  year: 2019
  ident: 355_CR103
  publication-title: ISMJ
  contributor:
    fullname: E Mirzazadeh
– volume: 14
  start-page: 644
  issue: 4
  year: 2015
  ident: 355_CR121
  publication-title: Aging Cell
  doi: 10.1111/acel.12344
  contributor:
    fullname: Y Zhu
– volume: 8
  start-page: 78
  year: 2022
  ident: 355_CR7
  publication-title: Phytother Res
  contributor:
    fullname: H Zalpoor
– volume: 26
  start-page: 408
  issue: 4
  year: 2015
  ident: 355_CR88
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2014.11.017
  contributor:
    fullname: P Wang
– volume: 8
  start-page: 647
  issue: 11
  year: 2012
  ident: 355_CR100
  publication-title: Nat Rev Neurol
  doi: 10.1038/nrneurol.2012.168
  contributor:
    fullname: H Lassmann
– volume: 2
  start-page: 659
  issue: 4
  year: 1996
  ident: 355_CR25
  publication-title: Clin Cancer Res
  contributor:
    fullname: DR Ferry
– volume: 237
  start-page: 17
  issue: 1
  year: 1997
  ident: 355_CR113
  publication-title: Neurosci Lett
  doi: 10.1016/S0304-3940(97)00797-0
  contributor:
    fullname: Y Kitamura
– volume: 181
  start-page: 467
  issue: 6
  year: 2020
  ident: 355_CR9
  publication-title: Int Arch Allergy Immunol
  doi: 10.1159/000508247
  contributor:
    fullname: F Seif
– volume: 81
  start-page: 698
  issue: 3
  year: 2021
  ident: 355_CR47
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-20-2066
  contributor:
    fullname: V Davra
– volume: 178
  start-page: 452
  year: 2019
  ident: 355_CR38
  publication-title: Colloids Surf B
  doi: 10.1016/j.colsurfb.2019.03.037
  contributor:
    fullname: H Tiwari
– volume: 136
  start-page: 2715
  issue: 11
  year: 2006
  ident: 355_CR5
  publication-title: J Nutr
  doi: 10.1093/jn/136.11.2715
  contributor:
    fullname: AB Granado-Serrano
– volume: 18
  start-page: 351
  issue: 5–6
  year: 2007
  ident: 355_CR34
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2007.06.003
  contributor:
    fullname: AG Hovanessian
– volume: 65
  start-page: 1059
  issue: 7
  year: 2013
  ident: 355_CR51
  publication-title: Nutr Cancer
  doi: 10.1080/01635581.2013.810291
  contributor:
    fullname: E Pozsgai
– volume: 358
  start-page: 547
  issue: 3
  year: 2001
  ident: 355_CR116
  publication-title: Biochem J
  doi: 10.1042/bj3580547
  contributor:
    fullname: H Schroeter
– volume: 25
  start-page: 1
  issue: 1
  year: 2020
  ident: 355_CR85
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-020-00216-x
  contributor:
    fullname: M Liao
– volume: 8
  issue: 4
  year: 2013
  ident: 355_CR99
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0057735
  contributor:
    fullname: A Ghosh
– volume: 27
  start-page: 1
  issue: 1
  year: 2022
  ident: 355_CR41
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-022-00332-w
  contributor:
    fullname: M Karami Fath
– volume: 11
  start-page: 733
  issue: 6
  year: 2008
  ident: 355_CR3
  publication-title: Curr Opin Clin Nutr Metab Care
  doi: 10.1097/MCO.0b013e32831394b8
  contributor:
    fullname: SC Bischoff
– ident: 355_CR98
– volume: 36
  start-page: 944
  issue: 6
  year: 2013
  ident: 355_CR86
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b12-01004
  contributor:
    fullname: H Youn
– volume: 89
  start-page: 140
  year: 2015
  ident: 355_CR122
  publication-title: Neurochem Int
  doi: 10.1016/j.neuint.2015.07.002
  contributor:
    fullname: F Dajas
– volume: 61
  start-page: 39
  issue: 1
  year: 2009
  ident: 355_CR115
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.108.000562
  contributor:
    fullname: SD Buckingham
– volume: 22
  start-page: 1
  issue: 9
  year: 2020
  ident: 355_CR37
  publication-title: Curr Rheumatol Rep
  doi: 10.1007/s11926-020-00931-6
  contributor:
    fullname: V Reddy
– volume: 27
  start-page: 1
  issue: 1
  year: 2022
  ident: 355_CR74
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-022-00321-z
  contributor:
    fullname: J Li
– volume: 46
  start-page: 356
  issue: 3
  year: 2020
  ident: 355_CR1
  publication-title: BioFactors
  doi: 10.1002/biof.1605
  contributor:
    fullname: E Tavana
– volume: 5
  start-page: 89
  year: 2016
  ident: 355_CR17
  publication-title: J Nutr Sci
  doi: 10.1017/jns.2016.41
  contributor:
    fullname: AN Panche
– volume: 37
  start-page: 198
  issue: 1
  year: 2020
  ident: 355_CR109
  publication-title: Neurotox Res
  doi: 10.1007/s12640-019-00120-z
  contributor:
    fullname: S Sharma
– volume: 273
  start-page: 580
  issue: 3
  year: 2013
  ident: 355_CR52
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2013.10.003
  contributor:
    fullname: J Jakubowicz-Gil
– volume: 35
  start-page: 2817
  issue: 6
  year: 2015
  ident: 355_CR114
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3516-14.2015
  contributor:
    fullname: LB Haim
– volume: 41
  start-page: 492
  issue: 5
  year: 2001
  ident: 355_CR26
  publication-title: J Clin Pharmacol
  doi: 10.1177/00912700122010366
  contributor:
    fullname: EU Graefe
– volume: 25
  start-page: 1
  issue: 1
  year: 2020
  ident: 355_CR83
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-020-00229-6
  contributor:
    fullname: S Xu
– volume: 19
  start-page: 1
  issue: 1
  year: 2021
  ident: 355_CR35
  publication-title: Clin Mol Allergy
  doi: 10.1186/s12948-021-00161-w
  contributor:
    fullname: M Nabi-Afjadi
– volume: 8
  start-page: 167
  issue: 3
  year: 2016
  ident: 355_CR119
  publication-title: Nutrients
  doi: 10.3390/nu8030167
  contributor:
    fullname: Y Li
– volume: 49
  start-page: 767
  issue: 03
  year: 2021
  ident: 355_CR48
  publication-title: Am J Chin Med
  doi: 10.1142/S0192415X21500361
  contributor:
    fullname: HI Kim
– volume-title: JAK-STAT Signalling Pathway in Cancer
  year: 2020
  ident: 355_CR13
  doi: 10.3390/cancers12071971
  contributor:
    fullname: AJ Brooks
– volume: 37
  start-page: 1269
  issue: 3
  year: 2010
  ident: 355_CR71
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-009-9501-y
  contributor:
    fullname: E Cengiz
– volume: 8
  issue: 69
  year: 2017
  ident: 355_CR6
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.22556
  contributor:
    fullname: I Igbe
– volume: 8
  start-page: 4806
  issue: 10
  year: 2019
  ident: 355_CR56
  publication-title: Cancer Med
  doi: 10.1002/cam4.2388
  contributor:
    fullname: L Wu
– volume: 43
  start-page: 441
  issue: 6
  year: 2008
  ident: 355_CR64
  publication-title: J Gastroenterol
  doi: 10.1007/s00535-008-2184-7
  contributor:
    fullname: R González-Segovia
– volume: 56
  start-page: 1649
  issue: 11
  year: 2004
  ident: 355_CR72
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2004.02.014
  contributor:
    fullname: L Brannon-Peppas
– volume: 24
  start-page: 2137
  issue: 14
  year: 2006
  ident: 355_CR84
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2005.05.2308
  contributor:
    fullname: F Kamangar
– volume: 12
  start-page: 591
  issue: 4
  year: 2022
  ident: 355_CR106
  publication-title: Life
  doi: 10.3390/life12040591
  contributor:
    fullname: D Wróbel-Biedrawa
– volume: 224
  start-page: 109
  year: 2019
  ident: 355_CR117
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2019.03.055
  contributor:
    fullname: E Zaplatic
– volume: 2021
  start-page: 88
  year: 2021
  ident: 355_CR33
  publication-title: Oxid Med Cell Long
  contributor:
    fullname: SR Soofiyani
– volume: 35
  start-page: 952
  issue: 3
  year: 2022
  ident: 355_CR40
  publication-title: Hum Cell
  doi: 10.1007/s13577-022-00697-2
  contributor:
    fullname: H Zalpoor
– volume: 47
  start-page: 1617
  issue: 5
  year: 2015
  ident: 355_CR60
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2015.3160
  contributor:
    fullname: P Khanna
– volume: 56
  start-page: 107966
  year: 2021
  ident: 355_CR62
  publication-title: Pharmacol Ther
  contributor:
    fullname: Y Song
– volume: 44
  issue: 9
  year: 2020
  ident: 355_CR79
  publication-title: J Food Biochem
  doi: 10.1111/jfbc.13374
  contributor:
    fullname: A Davoodvandi
– volume: 55
  start-page: 743
  issue: 5
  year: 2016
  ident: 355_CR73
  publication-title: Mol Carcinog
  doi: 10.1002/mc.22318
  contributor:
    fullname: A Srinivasan
– volume: 23
  start-page: 3307
  issue: 9
  year: 2016
  ident: 355_CR30
  publication-title: Drug Delivery
  doi: 10.1080/10717544.2016.1176087
  contributor:
    fullname: X Guan
– volume: 51
  start-page: 579
  issue: 2
  year: 2020
  ident: 355_CR59
  publication-title: J Gastrointest Cancer
  doi: 10.1007/s12029-019-00290-1
  contributor:
    fullname: S Eyvazi
– volume: 68
  start-page: 394
  issue: 6
  year: 2018
  ident: 355_CR53
  publication-title: Cancer J Clin
  doi: 10.3322/caac.21492
  contributor:
    fullname: F Bray
SSID ssj0020440
Score 2.4601347
SecondaryResourceType review_article
Snippet Abstract The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell...
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is involved in many immunological processes, including cell growth,...
The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth,...
Abstract The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell...
SourceID doaj
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 60
SubjectTerms Cancers
JAK–STAT inhibitor
Neurodegenerative diseases
Quercetin
Review Letter
Solid tumors
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhUMgltGlKt4-gQm9BZFdv5bYtDSGlhZAN5Cb0THyoN-x6D731P-Qf5pdkJHtLfOqlV8myxczImo-Z-Qahz4KHTP1UAzZhmXDhKTFZRhJdyiyzaaaVge_HT3l-zS9uxM2zVl8lJ6ynB-4Fd0K5M34mNUsARLRjmgblZwDZtc5Kxr50b2q2YGqAWqWRcq0rooJoONTbchktT9aFcEaTksVewmiCsNGVVJn7R-7mOFny2e1z9hLtD24jnvfbfYV2UnuAXvSNJH-_RvFyUxJUuqbFbo0dvph_f_zzcLWYL3DT3jUeju3qFMbvl13JDoI3laxCmMNgek3E3ebXcgUL24grwWVMt5WOuvwL8RDDWR-i67Nvi6_nZOifQALnoiNqmsEppSFxELkCnBV9iF6rVMqyuWeBakEjuBiqdP5UnnoNYEZIDygmpiDZG7TbLtv0FuEktAkyy1CitCnMnFEhZR6U084rZSboeCtCe9_TZNgKL7S0vcAtCNxWgVs2QV-KlP8-WSiu6wAo3g6Kt_9S_AR92urIwpEocQ7XpuVmbak0ghqwADpBaqS80RfHM21zV8m1wZ9VTJp3_2OL79EerXamCJUf0G632qSP4MN0_qia6xOFzuzs
  priority: 102
  providerName: Directory of Open Access Journals
Title Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
URI https://search.proquest.com/docview/2695294402
https://pubmed.ncbi.nlm.nih.gov/PMC9327369
https://doaj.org/article/24a9b1683e0948a382c7b120288f76d9
Volume 27
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswECWSFAV6Kbqi7mKwQG8FY5sUF_XmBAmCFAnS1gF8I8QtEVBThi0feus_9A_7JR3SUlFdexVFURgOxXmaxzcIfeCFDdRMFWATFkjBDSVlEI64ygcW2DTQrMB3dS0ubovLJV8eIN6fhcmkfWvq4_h9dRzr-8ytXK_spOeJTW6uTiHmkEyUk0N0CA7aQ_QOZaUayvlIEeVEwXruT8ooMdkmrRlFEoE9ZdA4SVV0GFdJA2s22Jiyfv8g6BxSJv_Zg86foMdd8Ijn-5d8ig58fIYe7stJ_niO3Jddoqm0dcTVFlf4cv75989f3xbzBa7jfW1g8W4-wfV10yaOEDwpcQuhDYMD1g63u1WzgY7R4Sxz6fxdFqVOX0TcZXK2L9Dt-dni9IJ0VRSILQreEjkNEJpS6wswvAS05Yx1RkmfDmcXhlmqOHUQaMhU_1MaahRAGi4MYBnnrWAv0VFson-FsOeqtCIIm3K13s6qUlofCisrVRkpyxH62JtQr_diGTqDDCX03vYabK-z7TUboZNk5b93JqHrfKHZ3OluujUtqtLMhGIecKiqmKJWmhmFqEgFKRwM-b6fIw0LI2U7quib3VZTUXJagjPQEZKDyRuMOGwBj8sS252Hvf7vnm_QI5r9TBIq3qKjdrPz7yB8ac0YnHYpx-jBydn1zddx_gkwzi78B_Nr8jE
link.rule.ids 230,315,730,783,787,867,888,2109,27936,27937,31732,33757,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFLVKEYINb8TwNBI7lHn4HXZDRTW0nQrEFHVnxY-0EUwymkkWsOIf-EO-hGsnQYQdbOM4TnLute-Vj89F6CVnNidmqiA3oXnCuCFJmguXuMznNKfTnEQFvuWpWJyxo3N-vod4fxYmkvatKcbll_W4LC4jt3KztpOeJzZ5vzyAmENSkU6uoKvgr1PWJ-ldnhWqKMdDRYQnCjy6PyujxGQX1GZUEijsYQ-NJ6GODuUqqGDNBktTVPAfhJ1D0uQfq9DhLfSpf_-WfPJ53NRmbL_9Je34zx94G93s4lI8b5vvoD1f3kXX2kqVX-8h96EJDJi6KHG2wxk-mh___P7j42q-wkV5WRiYF7av4fqmqgP9CJ4UaIvQhsG2C4frZl1toWPpcFTQdP4i6l2HyRZ3m0S7--js8O3qYJF0BRoSyxivEznNIeol1jPAVEIi54x1Rkkfzn0zQy1RnDiIYWQoLSoNMQqyJS4MpEnOW0EfoP2yKv1DhD1XqRW5sGEb2NtZlkrrc2ZlpjIjZTpCr3ps9KbV4dAxf1FCt6BqAFVHUDUdoTcBvt93Bg3teKHaXujuR2vCstTMhKIeUlyVUUWsNDMCAZfKpXAw5IsefA0-FzZSstJXzU4TkXKSgpWREZIDqxiMOGwBrKN6d4fto__u-RxdX6yWJ_rk3enxY3SDRGOWCRFP0H69bfxTiJJq8yz6xC9BTBDH
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagCMSFd8XyNBI3lH3Y8SPclsKqtLQqYitVXKz41UawyWo3OcCJ_8A_5JcwdhLUcOzVj1jOzNgzms_fIPSapcYTPZUQm1CfpEyTJPPcJjZ3nno69SQy8B0d8_3T9OCMnV0q9RVB-0YX4_L7alwWFxFbuV6ZSY8Tm5wc7YHPISjPJmvrJ9fRDbDZKe8D9S7WCpWU48MiwhIJVt2_l5F8sg2MMzIJMPaQR2NJqKVDmQxMWLPB9RRZ_Aeu5xA4eekmWtxFX_s9tACUb-Om1mPz8z96xytt8h660_mneN4OuY-uufIButlWrPzxENnPTUDC1EWJ8y3O8cH88M-v31-W8yUuyotCw_mweQvt66oOMCT4UoAvQh8GHS8srptVtYGJpcWRSdO688h7HQ5d3CWLto_Q6eLDcm8_6Qo1JCZNWZ2IqQfvlxiXgmwFBHRWG6ulcOH9d6qpIZIRC76MCCVGhSZaQtTEuIZwyTrD6S7aKavSPUbYMZkZ7rkJ6WBnZnkmjPOpEbnMtRDZCL3p5aPWLR-HinGM5KoVrALBqihYRUfoXRDhv5GBSzs2VJtz1f1sRdI80zMuqYNQV-ZUEiP0jIDjJb3gFpZ81SuAAtsLCZW8dFWzVYRnjGSgaWSExEAzBisOe0DekcW7k--TK898iW6dvF-oTx-PD5-i2yTqs0gIf4Z26k3jnoOzVOsX0Sz-AtGIE0c
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quercetin+as+a+JAK%E2%80%93STAT+inhibitor%3A+a+potential+role+in+solid+tumors+and+neurodegenerative+diseases&rft.jtitle=Cellular+%26+molecular+biology+letters&rft.au=Zalpoor%2C+Hamidreza&rft.au=Nabi-Afjadi%2C+Mohsen&rft.au=Forghaniesfidvajani%2C+Razieh&rft.au=Tavakol%2C+Chanour&rft.date=2022-07-26&rft.pub=BioMed+Central&rft.issn=1425-8153&rft.eissn=1689-1392&rft.volume=27&rft_id=info:doi/10.1186%2Fs11658-022-00355-3&rft_id=info%3Apmid%2F35883021&rft.externalDBID=PMC9327369
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1425-8153&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1425-8153&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1425-8153&client=summon