Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans

• Published in: The Journal of experimental medicine Vol. 214; no. 7; pp. 1889 - 1899
• Main Authors: Murray, Susan E., Nesterenko, Pavlo A., Vanarsdall, Adam L., Munks, Michael W., Smart, Savannah M., Veziroglu, Eren M., Sagario, Lavinia C., Lee, Ronzo, Claas, Frans H.J., Doxiadis, Ilias I.N., McVoy, Michael A., Adler, Stuart P., Hill, Ann B.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 03.07.2017; The Rockefeller University Press
• Subjects: Acquired immune deficiency syndrome; AIDS; Amino Acid Sequence; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell Line; Cell Line, Tumor; Cells, Cultured; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus - physiology; Cytomegalovirus Infections - immunology; Cytomegalovirus Infections - prevention & control; Cytomegalovirus Infections - virology; Cytomegalovirus Vaccines - administration & dosage; Cytomegalovirus Vaccines - genetics; Cytomegalovirus Vaccines - immunology; Epitopes - immunology; Fibroblasts; Fibroblasts - immunology; Fibroblasts - virology; Flow Cytometry; Herpesviridae; Histocompatibility antigen HLA; Histocompatibility Antigens Class I - immunology; Host-Pathogen Interactions - drug effects; Host-Pathogen Interactions - immunology; Human behavior; Human cytomegalovirus; Human subjects; Humans; K562 Cells; Lentivirus; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - virology; Lymphocytes; Lymphocytes T; Macaca mulatta; Major histocompatibility complex; Male; Microscopy, Fluorescence; Monkeys; Mutation; Retroviridae; T cell receptors; Tropism; Vaccination; Vaccines; Viruses

Cytomegalovirus (CMV)-based vaccines have shown remarkable efficacy in the rhesus macaque model of acquired immune deficiency syndrome, enabling 50% of vaccinated monkeys to clear a subsequent virulent simian immunodeficiency virus challenge. The protective vaccine elicited unconventional CD8 T cell...