S-adenosyl-l-methionine: effects on brain bioenergetic status and transverse relaxation time in healthy subjects

• Published in: Biological psychiatry (1969) Vol. 54; no. 8; pp. 833 - 839
• Main Authors: Silveri, Marisa M., Parow, Aimee M., Villafuerte, Rosemond A., Damico, Karen E., Goren, Jessica, Stoll, Andrew L., Cohen, Bruce M., Renshaw, Perry F.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.10.2003; Elsevier Science
• Subjects: 31P MRS; Adenosine Triphosphate - biosynthesis; Adenosine Triphosphate - blood; Administration, Oral; Adult; Adult and adolescent clinical studies; Antidepressive Agents - administration & dosage; Antidepressive Agents - pharmacokinetics; Antidepressive Agents - therapeutic use; Biological and medical sciences; Brain - blood supply; Brain - metabolism; cerebral metabolic function; Cerebrovascular Circulation - drug effects; Depression; Depressive Disorder, Major - drug therapy; Drug Administration Schedule; Energy Metabolism - drug effects; Female; Health Status; Humans; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Spectroscopy; Male; Medical sciences; Models, Biological; Mood disorders; MRI; Nervous system; Phosphocreatine - biosynthesis; Phosphocreatine - blood; Phosphorus - pharmacokinetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Relaxation; S-Adenosylmethionine - administration & dosage; S-Adenosylmethionine - pharmacokinetics; S-Adenosylmethionine - therapeutic use; SAMe; T2RT; SAMe; Depression; 31P MRS; cerebral metabolic function; MRI; T2RT; Human; Mood disorder; Statistical analysis; Healthy subject; Enzyme; Thioether hydrolases; Exploration; NMR spectrometry; Experimental study; Metabolism; Encephalon; Adenosylmethionine hydrolase; Hydrolases; Adult
• ISSN: 0006-3223; 1873-2402
• DOI: 10.1016/S0006-3223(03)00064-7

S-adenosyl-L-methionine is an effective treatment for clinical depression, although the mechanism underlying this effect is unclear. Presently, in vivo phosphorus 31 magnetic resonance spectroscopy and brain transverse relaxometry were employed to test if S-adenosyl-L-methionine supplementation alte...