Chronic Enhancement of Serotonin Facilitates Excitatory Transcranial Direct Current Stimulation-Induced Neuroplasticity

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 41; no. 5; pp. 1223 - 1230
• Main Authors: Kuo, Hsiao-I, Paulus, Walter, Batsikadze, Giorgi, Jamil, Asif, Kuo, Min-Fang, Nitsche, Michael A
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2016
• Subjects: Adult; Antidepressants; Brain research; Citalopram - administration & dosage; Cross-Over Studies; Dextromethorphan - administration & dosage; Double-Blind Method; Evoked Potentials, Motor - drug effects; Excitatory Amino Acid Antagonists - administration & dosage; Female; Humans; Male; Memory; Mental depression; Motor Cortex - drug effects; Motor Cortex - physiology; Neuronal Plasticity - drug effects; Original; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Serotonin; Serotonin - physiology; Serotonin Uptake Inhibitors - administration & dosage; Transcranial Direct Current Stimulation; Young Adult; Germany

Serotonin affects memory formation via modulating long-term potentiation (LTP) and depression (LTD). Accordingly, acute selective serotonin reuptake inhibitor (SSRI) administration enhanced LTP-like plasticity induced by transcranial direct current stimulation (tDCS) in humans. However, it usually t...