Protection from COVID-19 with a VSV-based vaccine expressing the spike and nucleocapsid proteins

• Published in: Frontiers in immunology Vol. 13; p. 1025500
• Main Authors: O’Donnell, Kyle L., Gourdine, Tylisha, Fletcher, Paige, Clancy, Chad S., Marzi, Andrea
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 24.10.2022
• Subjects: hamster model; Immunology; intranasal vaccination; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; vesicular stomatitis virus

Successful vaccine efforts countering the COVID-19 pandemic are centralized around the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein as viral antigen and have greatly reduced the morbidity and mortality associated with COVID-19. Since the start of this pandemic, SARS...