Markers of Mitochondrial Biogenesis and Metabolism Are Lower in Overweight and Obese Insulin-Resistant Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 92; no. 4; pp. 1467 - 1473
• Main Authors: Heilbronn, Leonie K., Gan, Seng Khee, Turner, Nigel, Campbell, Lesley V., Chisholm, Donald J.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.04.2007; Endocrine Society
• Subjects: Adipose Tissue - anatomy & histology; Adult; Aerobic capacity; Biological and medical sciences; Biomarkers; Body fat; Cardiorespiratory fitness; Citrate synthase; Cyclooxygenase 1 - genetics; Electron transport; Endocrinopathies; Enzymatic activity; Exercise; Fitness training programs; Fundamental and applied biological sciences. Psychology; Glucose Clamp Technique; Humans; Insulin - blood; Insulin Resistance; Male; Medical sciences; Metabolism; Mitochondria; Mitochondria, Muscle - genetics; Mitochondria, Muscle - metabolism; Mitochondria, Muscle - physiology; Mitochondrial DNA; Muscle, Skeletal - cytology; Muscle, Skeletal - pathology; Muscle, Skeletal - physiopathology; Obesity - physiopathology; Overweight - physiology; Oxygen Consumption; Physical fitness; Physical training; Protein turnover; Regression Analysis; Skeletal muscle; Vertebrates: endocrinology; Human; Resistance; Obesity; Pancreatic hormone; Mitochondria; Nutrition disorder; Biological marker; Metabolism; Insulin; Endocrinology; Nutritional status; Overweight
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2006-2210

Background: Impaired mitochondrial function in skeletal muscle is implicated in the development of insulin resistance. However, potential differences in fatness and fitness may influence previous results. Methods: Subjects (n =18) were divided into insulin-sensitive (IS) and insulin-resistant (IR) g...