The role of PANDER and its interplay with IL-6 in the regulation of GLP-1 secretion

• Published in: Endocrine Connections Vol. 13; no. 11; pp. 1 - 12
• Main Authors: Li, Zeting, Pei, Ling, Xiao, Huangmeng, Chen, Nan, Lai, Fenghua, Yue, Shufang, Xu, Changliu, Li, Yanbing, Xiao, Haipeng, Cao, Xiaopei
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.11.2024; Bioscientifica
• Subjects: family with sequence similarity 3b; gestational diabetes mellitus; glucose-like peptide-1; interleukin-6; pancreatic-derived factor

Glucose-like peptide-1 (GLP-1) is a vital hormone in the intestines that regulates glucose metabolism. Although pancreatic-derived factor (PANDER) overexpression is known to suppress GLP-1, the underlying mechanisms are unclear. Our study aims to uncover how PANDER influences GLP-1 synthesis and sec...