Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease

• Published in: Journal of proteomics Vol. 74; no. 4; pp. 466 - 479
• Main Authors: Chou, Jose L., Shenoy, Deepa V., Thomas, Nicy, Choudhary, Pankaj K., LaFerla, Frank M., Goodman, Steven R., Breen, Gail A.M.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.04.2011; Elsevier
• Subjects: 2D-DIGE; Adult and adolescent clinical studies; Alzheimer disease; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; amyloid; animal models; Animals; apoptosis; Biological and medical sciences; BN/SDS-PAGE; Comparative proteomics; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Disease Progression; Diverse techniques; fatty acids; Fundamental and applied biological sciences. Psychology; gel electrophoresis; gene expression regulation; genetically modified organisms; glycolysis; Humans; IEF/SDS-PAGE; Insulin-Like Growth Factor Binding Proteins - analysis; Insulin-Like Growth Factor Binding Proteins - chemistry; ion transport; Male; Medical sciences; mice; Mice - metabolism; Mice, Transgenic; mitochondria; Mitochondrial Proteins - analysis; Mitochondrial Proteins - metabolism; Mitochondrial proteomics; Models, Biological; Molecular and cellular biology; mutation; Neurofibrillary Tangles - metabolism; Neurology; Organic mental disorders. Neuropsychology; oxidation; oxidative phosphorylation; oxidative stress; pathogenesis; protein synthesis; proteome; Proteome - analysis; Proteome - metabolism; proteomics; Proteomics - methods; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; pyruvic acid; tandem mass spectrometry; Time Factors; transgenes; tricarboxylic acid cycle; Triple transgenic AD mice; Two-Dimensional Difference Gel Electrophoresis - methods; IEF/SDS-PAGE; 2D-DIGE; Mitochondrial proteomics; Comparative proteomics; BN/SDS-PAGE; Alzheimer's disease; Triple transgenic AD mice; Animal model; Alzheimer disease; Rodentia; Transgenic animal; Proteome; Vertebrata; Mitochondria; Mammalia; Mouse; Proteomics; Early

Mitochondrial structural and functional alterations appear to play to an important role in the pathogenesis of Alzheimer's disease (AD). In the present study, we used a quantitative comparative proteomic profiling approach to analyze changes in the mitochondrial proteome in AD. A triple transge...