Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 275; no. 4; pp. 717 - L728
• Main Authors: Ceneviva, Gary D, Tzeng, Edith, Hoyt, Dale G, Yee, Emily, Gallagher, Alicia, Engelhardt, John F, Kim, Young-Myeong, Billiar, Timothy R, Watkins, Simon A, Pitt, Bruce R
• Format: Journal Article
• Language: English
• Published: United States 01.10.1998
• Subjects: Adenoviridae; Animals; Apoptosis - drug effects; Apoptosis - physiology; Caspase 3; Caspases - metabolism; Cell Nucleus - drug effects; Cell Nucleus - physiology; Cell Nucleus - ultrastructure; Cells, Cultured; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Genetic Vectors; Humans; Lipopolysaccharides - antagonists & inhibitors; Lipopolysaccharides - pharmacology; Liver - enzymology; Mitochondria - drug effects; Mitochondria - physiology; Mitochondria - ultrastructure; Moloney murine leukemia virus; Nitric Oxide - physiology; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type II; Nitrites - metabolism; omega-N-Methylarginine - pharmacology; Pulmonary Artery; Recombinant Proteins - biosynthesis; Recombinant Proteins - metabolism; Sheep; Superoxide Dismutase - metabolism; Transfection; Vacuoles - ultrastructure

3  Department of Pharmacology; 1  Division of Pediatric Critical Care Medicine, Department of Anesthesiology; 2  Department of Surgery; 4  Division of Pulmonary, Allergy, and Critical Care Medicine; and 6  Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsb...