Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 41; no. 8; pp. 1974 - 1982
• Main Authors: Haney, Margaret, Malcolm, Robert J, Babalonis, Shanna, Nuzzo, Paul A, Cooper, Ziva D, Bedi, Gillinder, Gray, Kevin M, McRae-Clark, Aimee, Lofwall, Michelle R, Sparenborg, Steven, Walsh, Sharon L
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.07.2016
• Subjects: Administration, Oral; Adolescent; Adult; Affect - drug effects; Cannabidiol; Cannabidiol - administration & dosage; Cannabidiol - blood; Double-Blind Method; Dronabinol - administration & dosage; Drug abuse; Female; Heart rate; Heart Rate - drug effects; Humans; Intoxication; Male; Marijuana; Marijuana Smoking; Middle Aged; Original; Physiology; Ratings & rankings; Reinforcement (Psychology); Self Administration; Tetrahydrocannabinol; THC; Young Adult; New York; United States > US

Cannabidiol (CBD), a constituent of cannabis with few psychoactive effects, has been reported in some studies to attenuate certain aspects of Δ(9)-tetrahydrocannabinol (THC) intoxication. However, most studies have tested only one dose of CBD in combination with one dose of oral THC, making it diffi...