Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus

Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, thei...

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Published inInternational journal of molecular sciences Vol. 18; no. 8; p. 1769
Main Authors Tarasen, Ashley, Carlson, J Andrew, Leonard, M Kathryn, Merlino, Glenn, Kaetzel, David, Slominski, Andrzej T
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 15.08.2017
MDPI
Subjects
Aged
Animals
Biopsy
Carney complex
Case Report
Epidermis
Hair
hair follicle
Hair Follicle - metabolism
Hair Follicle - pathology
hair follicle stem cell
Hair loss
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
Humans
Male
melanin pigment
Melanocytes
Melanoma
Melanoma - metabolism
Melanoma - pathology
Nevus
Nevus, Intradermal - metabolism
Nevus, Intradermal - pathology
Scalp
Scalp - metabolism
Scalp - pathology
Skin
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Squamous cell carcinoma
Stem cell transplantation
Stem cells
Tumors
melanin pigment
hair follicle
melanoma
hair follicle stem cell
melanocytes
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Abstract Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge. We present two cases of PEM/ATM in a 63 year-old male on the scalp with follicular origin and a 72 year-old female on the upper back arising in an intradermal nevus. Biopsy of both cases revealed a proliferation of heavily pigmented dermal nests of melanocytes with atypia. The Case 1 tumor was in continuation with the outer root sheath of the hair follicle in the bulge region. Case 2 arose in an intradermal melanocytic nevus. Rare mitotic figures, including atypical mitotic figures, were identified in both cases. We present two cases of PEM, with histologic evidence suggesting two origins: one from the follicular bulb and one from an intradermal nevus.
AbstractList Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge. We present two cases of PEM/ATM in a 63 year-old male on the scalp with follicular origin and a 72 year-old female on the upper back arising in an intradermal nevus. Biopsy of both cases revealed a proliferation of heavily pigmented dermal nests of melanocytes with atypia. The Case 1 tumor was in continuation with the outer root sheath of the hair follicle in the bulge region. Case 2 arose in an intradermal melanocytic nevus. Rare mitotic figures, including atypical mitotic figures, were identified in both cases. We present two cases of PEM, with histologic evidence suggesting two origins: one from the follicular bulb and one from an intradermal nevus.
Author Carlson, J Andrew
Kaetzel, David
Tarasen, Ashley
Merlino, Glenn
Leonard, M Kathryn
Slominski, Andrzej T
AuthorAffiliation 1 Departments of Dermatology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35201, USA; ashleytarasen@gmail.com
2 Department of Dermatopathology, Albany Medical College, Albany, NY 12201, USA; carlsoa@mail.amc.edu
3 Department of Biochemistry and Molecular Biology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA; KLeonard@som.umaryland.edu (M.K.L.); DKaetzel@som.umaryland.edu (D.K.)
5 Veterans Affairs Medical Center, Birmingham, AL 35201, USA
4 Center for Cancer Research, National Cancer Institute, Bethesda, MD 21201, USA; gmerlino@helix.nih.gov
AuthorAffiliation_xml – name: 2 Department of Dermatopathology, Albany Medical College, Albany, NY 12201, USA; carlsoa@mail.amc.edu
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– name: 5 Veterans Affairs Medical Center, Birmingham, AL 35201, USA
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Issue 8
Keywords melanin pigment
hair follicle
melanoma
hair follicle stem cell
melanocytes
Language English
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Notes Abstract Presented during the Poster Session at the American Society of Dermatopathology (ASDP) 2015 Annual Meeting, October, 2015, San Francisco, CA 94101, USA.
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SSID ssj0023259
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Snippet Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type...
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SourceType Open Website
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Aggregation Database
Index Database
StartPage 1769
SubjectTerms Aged
Animals
Biopsy
Carney complex
Case Report
Epidermis
Hair
hair follicle
Hair Follicle - metabolism
Hair Follicle - pathology
hair follicle stem cell
Hair loss
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
Humans
Male
melanin pigment
Melanocytes
Melanoma
Melanoma - metabolism
Melanoma - pathology
Nevus
Nevus, Intradermal - metabolism
Nevus, Intradermal - pathology
Scalp
Scalp - metabolism
Scalp - pathology
Skin
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Squamous cell carcinoma
Stem cell transplantation
Stem cells
Tumors
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Title Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus
URI https://www.ncbi.nlm.nih.gov/pubmed/28809777
https://www.proquest.com/docview/1939845005
https://pubmed.ncbi.nlm.nih.gov/PMC5578158
https://doaj.org/article/625631b4c3494bc2a39690b43bc25883
Volume 18
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