Are Steroid Hormones Dysregulated in Autistic Girls?

Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hor...

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Published inDiseases Vol. 8; no. 1; p. 6
Main Authors Gasser, Benedikt Andreas, Kurz, Johann, Dick, Bernhard, Mohaupt, Markus Georg
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.03.2020
MDPI
Subjects
21-hydroxylase
Adrenal glands
Age
Androgens
Androstenediol
Autism
Autistic children
Cholesterol
Development and progression
Disease sex factors
Enzymes
Gas chromatography
gas chromatography-mass spectrometry
Girls
Health aspects
Hormones
Hypotheses
Mass spectroscopy
Metabolites
Pediatric research
Physiological aspects
Ratios
Risk factors
Steroid hormones
Steroids
Testosterone
Urine
Values
Switzerland
United States > US
Austria
cholesterol
gas chromatography-mass spectrometry
21-hydroxylase
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Abstract Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hormone metabolite analysis was conducted from autistic girls. Results show increased levels of several steroid hormones, especially in the class of androgens in autistic girls such as testosterone or androstenediol. The increase of the majority of steroid hormones in autistic girls is probably best explained multifactorially by a higher substrate provision in line with the previously developed cholesterol hypothesis of autism.
AbstractList Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hormone metabolite analysis was conducted from autistic girls. Results show increased levels of several steroid hormones, especially in the class of androgens in autistic girls such as testosterone or androstenediol. The increase of the majority of steroid hormones in autistic girls is probably best explained multifactorially by a higher substrate provision in line with the previously developed cholesterol hypothesis of autism.
Audience Academic
Author Mohaupt, Markus Georg
Dick, Bernhard
Kurz, Johann
Gasser, Benedikt Andreas
AuthorAffiliation 1 Department of Clinical Research, University of Bern, 3010 Berne, Switzerland; bernhard.dick@gmx.ch
2 Teaching Hospital Internal Medicine, Lindenhofgruppe, 3006 Berne, Switzerland; john@a1.net (J.K.); markus.mohaupt@lindenhofgruppe.ch (M.G.M.)
AuthorAffiliation_xml – name: 2 Teaching Hospital Internal Medicine, Lindenhofgruppe, 3006 Berne, Switzerland; john@a1.net (J.K.); markus.mohaupt@lindenhofgruppe.ch (M.G.M.)
– name: 1 Department of Clinical Research, University of Bern, 3010 Berne, Switzerland; bernhard.dick@gmx.ch
Author_xml – sequence: 1
  givenname: Benedikt Andreas
  surname: Gasser
  fullname: Gasser, Benedikt Andreas
  organization: Department of Clinical Research, University of Bern, 3010 Berne, Switzerland
– sequence: 2
  givenname: Johann
  surname: Kurz
  fullname: Kurz, Johann
  organization: Teaching Hospital Internal Medicine, Lindenhofgruppe, 3006 Berne, Switzerland
– sequence: 3
  givenname: Bernhard
  surname: Dick
  fullname: Dick, Bernhard
  organization: Department of Clinical Research, University of Bern, 3010 Berne, Switzerland
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  givenname: Markus Georg
  surname: Mohaupt
  fullname: Mohaupt, Markus Georg
  organization: Teaching Hospital Internal Medicine, Lindenhofgruppe, 3006 Berne, Switzerland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32183287$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords cholesterol
gas chromatography-mass spectrometry
21-hydroxylase
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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Snippet Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic...
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StartPage 6
SubjectTerms 21-hydroxylase
Adrenal glands
Age
Androgens
Androstenediol
Autism
Autistic children
Cholesterol
Development and progression
Disease sex factors
Enzymes
Gas chromatography
gas chromatography-mass spectrometry
Girls
Health aspects
Hormones
Hypotheses
Mass spectroscopy
Metabolites
Pediatric research
Physiological aspects
Ratios
Risk factors
Steroid hormones
Steroids
Testosterone
Urine
Values
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Title Are Steroid Hormones Dysregulated in Autistic Girls?
URI https://www.ncbi.nlm.nih.gov/pubmed/32183287
https://www.proquest.com/docview/2379137310/abstract/
https://search.proquest.com/docview/2378898654
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https://doaj.org/article/0ca62a7182fd49b9b572cd0f926d36f3
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