Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 54; no. 9; pp. 2755 - 2763
• Main Authors: KJØRHOLT, Cecilie, AKERFELDT, Mia C, BIDEN, Trevor J, LAYBUTT, D. Ross
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.2005
• Subjects: Aging; Animals; Biological and medical sciences; Blood lipids; Cell Differentiation - physiology; Diabetes Mellitus - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Gene Expression Regulation - physiology; Hyperglycemia; Hyperglycemia - physiopathology; Insulin - metabolism; Islets of Langerhans - cytology; Islets of Langerhans - metabolism; Lipids - blood; Medical sciences; Mice; Observations; Pancreatic beta cells; RNA, Messenger - metabolism; Australia; Endocrinopathy; Animal model; Diabetes mellitus; Langerhans islet; Rodentia; Lipids; Cell differentiation; Vertebrata; Chronic; Hyperglycemia; Mammalia; Mouse; Animal; β Cell; Endocrine pancreas

Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes Cecilie Kjørholt , Mia C. Åkerfeldt , Trevor J. Biden and D. Ross Laybutt From the Diabetes and Obesity Research Program, Garvan...