Functional Regeneration of Supraspinal Connections in a Patient with Transected Spinal Cord following Transplantation of Bulbar Olfactory Ensheathing Cells with Peripheral Nerve Bridging

• Published in: Cell transplantation Vol. 23; no. 12; pp. 1631 - 1655
• Main Authors: Tabakow, Pawel, Raisman, Geoffrey, Fortuna, Wojciech, Czyz, Marcin, Huber, Juliusz, Li, Daqing, Szewczyk, Pawel, Okurowski, Stefan, Miedzybrodzki, Ryszard, Czapiga, Bogdan, Salomon, Beata, Halon, Agnieszka, Li, Ying, Lipiec, Joanna, Kulczyk, Aleksandra, Jarmundowicz, Wlodzimierz
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2014; SAGE Publishing
• Subjects: Adult; Anisotropy; Cells, Cultured; Diffusion Tensor Imaging; Electromyography; Evoked Potentials, Motor; Humans; Male; Microinjections; Motor Activity; Nerve Regeneration; Olfactory Bulb - cytology; Olfactory Bulb - transplantation; Olfactory Nerve - physiology; Olfactory Perception; Recovery of Function; Smell; Spinal Cord Injuries - pathology; Spinal Cord Injuries - physiopathology; Spinal Cord Injuries - rehabilitation; Spinal Cord Injuries - therapy; Regeneration; Paraplegia; Repair; Cell transplantation

Treatment of patients sustaining a complete spinal cord injury remains an unsolved clinical problem because of the lack of spontaneous regeneration of injured central axons. A 38-year-old man sustained traumatic transection of the thoracic spinal cord at upper vertebral level Th9. At 21 months after...