Controlled ruminal infusion of sodium bicarbonate. 3. Influence of infusion dose on systemic acid-base status, minerals, and ruminal milieu

• Published in: Journal of dairy science Vol. 76; no. 8; pp. 2222 - 2234
• Main Authors: Tucker, W. B, Hogue, J. F, Aslam, M, Lema, M, Le Ruyet, P, Shin, I. S, Van Koevering, M. T, Vernon, R. K, Adams, G. D
• Format: Journal Article
• Language: English
• Published: United States Am Dairy Sci Assoc 01.08.1993; American Dairy Science Association
• Subjects: acid base equilibrium; Acid-Base Equilibrium - drug effects; Animals; bicarbonate de sodium; bicarbonato sodico; blood; buffers; Calcium - urine; Cattle - physiology; dairy cows; digestive juices; Diuresis - drug effects; equilibre acidobasique; equilibrio acido base; excrecion; excretion; jugos digestivos; Magnesium - urine; metabolic disorders; metabolism; metabolisme; metabolisme des mineraux; metabolismo; metabolismo de minerales; mineral metabolism; Minerals - metabolism; orina; Potassium - urine; pouvoir tampon; rumen; Rumen - drug effects; Rumen - physiology; sang; sangre; Sodium - urine; sodium bicarbonate; Sodium Bicarbonate - administration & dosage; Sodium Bicarbonate - pharmacology; soluciones reguladoras; suc digestif; trastornos metabolicos; trouble du metabolisme; urine; vacas lecheras; vache laitiere
• DOI: 10.3168/jds.S0022-0302(93)77559-1
• ISSN: 0022-0302

Four ruminally cannulated, lactating Holstein cows were assigned to a 4 X 4 Latin square to monitor effects of intraruminal NaHCO3 infusion on temporal changes in ruminal and systemic acid-base status and mineral metabolism. Twice daily from 2 to 4 h postfeeding, cows were infused with 0, 110, 220, or 330 g of NaHCO3 dissolved in 3.8 L of water. All cows had access to their TMR of sorghum silage and concentrate (35:65, DM basis) for 2 h twice daily. Ruminal fluid, blood, and urine were collected at feeding and every 30 min postfeeding for 12 h on the last day of each 14-d period. Total urine volume also was measured during this interval. Infusion of buffer increased ruminal fluid buffering capacity transiently at 4.5 h postfeeding but otherwise did not markedly affect ruminal fluid acid-base status. Systemic acid-base status was unaffected by the buffer primarily because renal excretion of base successfully reduced systemic base load. Urine volume increased in response to NaHCO3 infusion. Buffer infusion increased urinary excretion of Na, Mg, and K but decreased Ca excretion for 12 h postfeeding; Cl excretion was not affected. Buffer infusion tended to increase total VFA in ruminal fluid. Our data indicate that homeostatic mechanisms can eliminate exogenous base via the kidneys; hence, acid-base status was not perturbed by infusion of NaHCO3. The increased excretion of Mg and K with buffer infusion indicates that the dietary requirements for these minerals may be increased by NaHCO3. Although loss of Ca through the urine was reduced by buffer infusion, this reduction may indicate reduced availability of Ca to the cow. The diuresis accompanying large doses of NaHCO3 may increase dietary requirements for some minerals.