Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease

• Published in: Journal of Alzheimer's disease Vol. 53; no. 1; p. 349
• Main Authors: Tajeddinn, Walid, Persson, Torbjörn, Calvo-Garrido, Javier, Seed Ahmed, Mohammed, Maioli, Silvia, Vijayaraghavan, Swetha, Kazokoglu, Mehmet Selim, Parrado-Fernández, Cristina, Yoshitake, Takashi, Kehr, Jan, Francis, Paul, Winblad, Bengt, Höglund, Kina, Cedazo-Minguez, Angel, Aarsland, Dag
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2016
• Subjects: Amyloid beta-Protein Precursor - genetics; Cell Line, Tumor; Chromatography, Liquid; Electrochemical Techniques; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; Humans; Hydroxyindoleacetic Acid - metabolism; Mitogen-Activated Protein Kinase Kinases - metabolism; Monoamine Oxidase - metabolism; Mutation - genetics; Neuroblastoma - pathology; Phosphorylation - drug effects; Piperidones - pharmacology; Receptor, Serotonin, 5-HT1B - genetics; Receptor, Serotonin, 5-HT1B - metabolism; RNA, Messenger - metabolism; Serotonin - metabolism; Serotonin - pharmacology; Serotonin Agents - pharmacology; Serotonin Plasma Membrane Transport Proteins - metabolism; Spiro Compounds - pharmacology; Statistics, Nonparametric; Transfection; p11; SERT; serotonin; Alzheimer’s disease; MAOA; 5-HT1B receptor; APPswe

Serotonin (5-HT) plays a central role in the integrity of different brain functions. The 5-HT homeostasis is regulated by many factors, including serotonin transporter (SERT), monoamine oxidase enzyme (MAO), and several 5-HT receptors, including the 5-HT1B. There is little knowledge how the dynamics...