Mesothelioma and Colorectal Cancer: Report of Four Cases with Synchronous and Metachronous Presentation

There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from gastric, biliary, colon cancers has been reported, but the mechanism is still controversial. It has been hypothesised that asbestos reaches these...

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Published inInternational journal of molecular sciences Vol. 23; no. 5; p. 2630
Main Authors Serio, Gabriella, Pezzuto, Federica, Fortarezza, Francesco, Marzullo, Andrea, Delfino, Maria Celeste, d'Amati, Antonio, Romano, Daniele Egidio, Maniglio, Sonia, Caporusso, Concetta, Lettini, Teresa, Cavone, Domenica, Vimercati, Luigi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2022
MDPI
Subjects
Asbestos
Asbestos - toxicity
BAP1
Breast cancer
Cancer therapies
Carcinogenesis
Carcinogens
Case Report
Cell cycle
Cell growth
Chemotherapy
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - chemically induced
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Cyclin-dependent kinase
Cyclin-dependent kinases
Disease
Enzyme inhibitors
Family medical history
Fibers
Humans
Kinases
Lung Neoplasms - etiology
Lung Neoplasms - genetics
Medical prognosis
Mesothelioma
Mesothelioma - chemically induced
Mesothelioma - diagnosis
Mesothelioma, Malignant
Mortality
Mutation
Organs
Patients
peritoneum
pleura
Tumor suppressor genes
Tumor Suppressor Proteins - genetics
Tumors
Ubiquitin Thiolesterase - genetics
peritoneum
asbestos
CDKN2A
colon cancer
pleura
mesothelioma
BAP1
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Abstract There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from gastric, biliary, colon cancers has been reported, but the mechanism is still controversial. It has been hypothesised that asbestos reaches these sites, especially through contaminated water; however, some experimental studies have shown that the inhaled fibres are mobile, so they can migrate to many organs, directly or via blood and lymph flow. We report four unusual cases of colorectal cancers in patients with a long history of asbestos exposure who also developed synchronous or metachronous mesothelioma. We evaluated the roles of BRCA associated protein-1 ( ) and cyclin-dependent kinase inhibitor 2A ( ) in colon cancer and mesothelioma to support the hypothesis that and are tumour suppressor genes involved in disease progression, recurrence, or death in both digestive cancers and mesothelioma. Potentially, these markers may be used as predictors of worse prognosis, but we also stress the importance of clinical surveillance of exposed patients because asbestos could induce cancer in any organ.
AbstractList There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from gastric, biliary, colon cancers has been reported, but the mechanism is still controversial. It has been hypothesised that asbestos reaches these sites, especially through contaminated water; however, some experimental studies have shown that the inhaled fibres are mobile, so they can migrate to many organs, directly or via blood and lymph flow. We report four unusual cases of colorectal cancers in patients with a long history of asbestos exposure who also developed synchronous or metachronous mesothelioma. We evaluated the roles of BRCA associated protein-1 ( BAP1 ) and cyclin-dependent kinase inhibitor 2A ( CDKN2A ) in colon cancer and mesothelioma to support the hypothesis that BAP-1 and CDKN2A are tumour suppressor genes involved in disease progression, recurrence, or death in both digestive cancers and mesothelioma. Potentially, these markers may be used as predictors of worse prognosis, but we also stress the importance of clinical surveillance of exposed patients because asbestos could induce cancer in any organ.
There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from gastric, biliary, colon cancers has been reported, but the mechanism is still controversial. It has been hypothesised that asbestos reaches these sites, especially through contaminated water; however, some experimental studies have shown that the inhaled fibres are mobile, so they can migrate to many organs, directly or via blood and lymph flow. We report four unusual cases of colorectal cancers in patients with a long history of asbestos exposure who also developed synchronous or metachronous mesothelioma. We evaluated the roles of BRCA associated protein-1 ( ) and cyclin-dependent kinase inhibitor 2A ( ) in colon cancer and mesothelioma to support the hypothesis that and are tumour suppressor genes involved in disease progression, recurrence, or death in both digestive cancers and mesothelioma. Potentially, these markers may be used as predictors of worse prognosis, but we also stress the importance of clinical surveillance of exposed patients because asbestos could induce cancer in any organ.
There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from gastric, biliary, colon cancers has been reported, but the mechanism is still controversial. It has been hypothesised that asbestos reaches these sites, especially through contaminated water; however, some experimental studies have shown that the inhaled fibres are mobile, so they can migrate to many organs, directly or via blood and lymph flow. We report four unusual cases of colorectal cancers in patients with a long history of asbestos exposure who also developed synchronous or metachronous mesothelioma. We evaluated the roles of BRCA associated protein-1 (BAP1) and cyclin-dependent kinase inhibitor 2A (CDKN2A) in colon cancer and mesothelioma to support the hypothesis that BAP-1 and CDKN2A are tumour suppressor genes involved in disease progression, recurrence, or death in both digestive cancers and mesothelioma. Potentially, these markers may be used as predictors of worse prognosis, but we also stress the importance of clinical surveillance of exposed patients because asbestos could induce cancer in any organ.
Author Cavone, Domenica
Fortarezza, Francesco
Maniglio, Sonia
Vimercati, Luigi
Delfino, Maria Celeste
Lettini, Teresa
Pezzuto, Federica
d'Amati, Antonio
Romano, Daniele Egidio
Caporusso, Concetta
Serio, Gabriella
Marzullo, Andrea
AuthorAffiliation 3 Pathology Unit, University Hospital of Padova, University of Padova, 61 N. A. Gabelli St., 35121 Padova, Italy
4 Department of Interdisciplinary Medicine, Occupational Health Division, Internal Medicine Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy; maria.delfino@uniba.it (M.C.D.); domenica.cavone@uniba.it (D.C.); luigi.vimercati@uniba.it (L.V.)
2 Department of Cardiac, Thoracic, Vascular Sciences and Public Health—DCTV, Pathology Unit, University of Padova, 61 N. A. Gabelli St., 35121 Padova, Italy; federica.pezzuto@unipd.it
1 Department of Emergency and Organ Transplantation—DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy; gabriella.serio1@uniba.it (G.S.); andrea.marzullo@uniba.it (A.M.); damatiantonio@yahoo.it (A.d.); danieleromano95@gmail.com (D.E.R.); sonya1996@hotmail.it (S.M.); kcaporusso.c@libero.it (C.C.); lettinit@yahoo.com (T.L.)
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– name: 1 Department of Emergency and Organ Transplantation—DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy; gabriella.serio1@uniba.it (G.S.); andrea.marzullo@uniba.it (A.M.); damatiantonio@yahoo.it (A.d.); danieleromano95@gmail.com (D.E.R.); sonya1996@hotmail.it (S.M.); kcaporusso.c@libero.it (C.C.); lettinit@yahoo.com (T.L.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35269773$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords peritoneum
asbestos
CDKN2A
colon cancer
pleura
mesothelioma
BAP1
Language English
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Snippet There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from...
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SubjectTerms Asbestos
Asbestos - toxicity
BAP1
Breast cancer
Cancer therapies
Carcinogenesis
Carcinogens
Case Report
Cell cycle
Cell growth
Chemotherapy
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - chemically induced
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Cyclin-dependent kinase
Cyclin-dependent kinases
Disease
Enzyme inhibitors
Family medical history
Fibers
Humans
Kinases
Lung Neoplasms - etiology
Lung Neoplasms - genetics
Medical prognosis
Mesothelioma
Mesothelioma - chemically induced
Mesothelioma - diagnosis
Mesothelioma, Malignant
Mortality
Mutation
Organs
Patients
peritoneum
pleura
Tumor suppressor genes
Tumor Suppressor Proteins - genetics
Tumors
Ubiquitin Thiolesterase - genetics
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Title Mesothelioma and Colorectal Cancer: Report of Four Cases with Synchronous and Metachronous Presentation
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Volume 23
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