Mortality and Morbidity in Pre-sensitized Pediatric Heart Transplant Recipients With a Positive Donor Crossmatch Utilizing Peri-operative Plasmapheresis and Cytolytic Therapy

• Published in: The Journal of heart and lung transplantation Vol. 26; no. 9; pp. 876 - 882
• Main Authors: Holt, D. Byron, MD, Lublin, Douglas M., MD, Phelan, Donna L., CHS, Boslaugh, Sarah E., PhD, MPH, Gandhi, Sanjiv K., MD, Huddleston, Charles B., MD, Saffitz, Jeffrey E., MD, Canter, Charles E., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2007; Elsevier Science
• Subjects: Adolescent; Adult; Antilymphocyte Serum - therapeutic use; Biological and medical sciences; Child; Child, Preschool; Cyclophosphamide - therapeutic use; Cytotoxicity Tests, Immunologic; Graft Rejection - therapy; Heart Transplantation; Histocompatibility; HLA Antigens - immunology; Humans; Immunosuppressive Agents - therapeutic use; Infant; Isoantibodies - blood; Medical sciences; Perioperative Care; Plasmapheresis; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Human; Heart; Suboptimal donor; Pediatrics; Therapy; Respiratory disease; Mortality; Cardiovascular disease; Transplantation; Homotransplantation; Epidemiology; Morbidity; Plasmapheresis; Treatment; Surgery; Graft; Child

Background The difficulty in obtaining a prospective negative donor/recipient crossmatch limits the ability to successfully transplant pediatric heart transplant candidates who show evidence of antibodies to multiple human leukocyte antigens (pre-sensitized patients). Methods We utilized a protocol...