Walnut intake may increase circulating adiponectin and leptin levels but does not improve glycemic biomarkers: A systematic review and meta-analysis of randomized clinical trials

•The walnut administration significant increasing serum leptin and adiponectin.•The walnut administration did not changes in fasting blood glucose (FBG).•The walnut administration did not changes in insulin, and glycated hemoglobin (HbA1c) concentrations. Background & objective: Walnut intake is...

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Published inComplementary therapies in medicine Vol. 52; no. NA; p. 102505
Main Authors Yang, Ling, Guo, Zhiyang, Qi, Shuwen, Fang, Tao, Zhu, Hongyan, Santos, Heitor O., Khani, Vahid, Wong, Chun Hoong, Qiu, Zhiyun
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.08.2020
Elsevier Limited
Subjects
Adiponectin
Bias
Biomarkers
Blood glucose
Clinical trials
Diabetes
Dietary intake
Fatty acids
Glucose
HbA1c
Hemoglobin
Hyperglycemia
Insulin
Insulin resistance
Investigations
Leptin
Meta-analysis
Metabolism
Sensitivity analysis
Systematic review
Walnut
United States > US
Glucose
Walnut
HbA1c
Insulin
Leptin
Adiponectin
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Abstract •The walnut administration significant increasing serum leptin and adiponectin.•The walnut administration did not changes in fasting blood glucose (FBG).•The walnut administration did not changes in insulin, and glycated hemoglobin (HbA1c) concentrations. Background & objective: Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well. The literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019. Fourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 % CI: 2.147–2.856, p < 0.001) and adiponectin (WMD: 0.440 ng/mL; 95 % CI: 0.323 to 0.557, p < 0.001) levels. Pertaining to glycemic biomarkers, neither overall analyses nor sub-analyses corroborated with changes in fasting blood glucose (WMD: 0.500 mg/dL, 95 % CI: -0.596, 1.596, p = 0.371), insulin (WMD: -0.21 mg/dL, 95 % CI: -0.67, 0.24, p = 0.367), and glycated hemoglobin (WMD: 0.004 mg/dL, 95 % CI: -0.041, 0.049, p = 0.870) concentrations. Walnut intake may increase leptin and adiponectin levels but does not improve glycemic biomarkers.
AbstractList Background & objective: Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well.MethodsThe literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019.ResultsFourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 % CI: 2.147–2.856, p < 0.001) and adiponectin (WMD: 0.440 ng/mL; 95 % CI: 0.323 to 0.557, p < 0.001) levels. Pertaining to glycemic biomarkers, neither overall analyses nor sub-analyses corroborated with changes in fasting blood glucose (WMD: 0.500 mg/dL, 95 % CI: -0.596, 1.596, p = 0.371), insulin (WMD: -0.21 mg/dL, 95 % CI: -0.67, 0.24, p = 0.367), and glycated hemoglobin (WMD: 0.004 mg/dL, 95 % CI: -0.041, 0.049, p = 0.870) concentrations.ConclusionWalnut intake may increase leptin and adiponectin levels but does not improve glycemic biomarkers.
Highlights: The walnut administration significant increasing serum leptin and adiponectin. The walnut administration did not changes in fasting blood glucose (FBG). The walnut administration did not changes in insulin, and glycated hemoglobin (HbA1c) concentrations. Abstract: Background & objective: Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well. Methods: The literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019. Results: Fourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 %
Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well.BACKGROUND & OBJECTIVEWalnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well.The literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019.METHODSThe literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019.Fourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 % CI: 2.147-2.856, p < 0.001) and adiponectin (WMD: 0.440 ng/mL; 95 % CI: 0.323 to 0.557, p < 0.001) levels. Pertaining to glycemic biomarkers, neither overall analyses nor sub-analyses corroborated with changes in fasting blood glucose (WMD: 0.500 mg/dL, 95 % CI: -0.596, 1.596, p = 0.371), insulin (WMD: -0.21 mg/dL, 95 % CI: -0.67, 0.24, p = 0.367), and glycated hemoglobin (WMD: 0.004 mg/dL, 95 % CI: -0.041, 0.049, p = 0.870) concentrations.RESULTSFourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 % CI: 2.147-2.856, p < 0.001) and adiponectin (WMD: 0.440 ng/mL; 95 % CI: 0.323 to 0.557, p < 0.001) levels. Pertaining to glycemic biomarkers, neither overall analyses nor sub-analyses corroborated with changes in fasting blood glucose (WMD: 0.500 mg/dL, 95 % CI: -0.596, 1.596, p = 0.371), insulin (WMD: -0.21 mg/dL, 95 % CI: -0.67, 0.24, p = 0.367), and glycated hemoglobin (WMD: 0.004 mg/dL, 95 % CI: -0.041, 0.049, p = 0.870) concentrations.Walnut intake may increase leptin and adiponectin levels but does not improve glycemic biomarkers.CONCLUSIONWalnut intake may increase leptin and adiponectin levels but does not improve glycemic biomarkers.
•The walnut administration significant increasing serum leptin and adiponectin.•The walnut administration did not changes in fasting blood glucose (FBG).•The walnut administration did not changes in insulin, and glycated hemoglobin (HbA1c) concentrations. Background & objective: Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well. The literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019. Fourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 % CI: 2.147–2.856, p < 0.001) and adiponectin (WMD: 0.440 ng/mL; 95 % CI: 0.323 to 0.557, p < 0.001) levels. Pertaining to glycemic biomarkers, neither overall analyses nor sub-analyses corroborated with changes in fasting blood glucose (WMD: 0.500 mg/dL, 95 % CI: -0.596, 1.596, p = 0.371), insulin (WMD: -0.21 mg/dL, 95 % CI: -0.67, 0.24, p = 0.367), and glycated hemoglobin (WMD: 0.004 mg/dL, 95 % CI: -0.041, 0.049, p = 0.870) concentrations. Walnut intake may increase leptin and adiponectin levels but does not improve glycemic biomarkers.
ArticleNumber 102505
Author Qi, Shuwen
Guo, Zhiyang
Zhu, Hongyan
Khani, Vahid
Qiu, Zhiyun
Santos, Heitor O.
Yang, Ling
Fang, Tao
Wong, Chun Hoong
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  organization: Department of Emergency, Guangfeng People's Hospital, Yongfeng South Street, Shangrao, Jiangxi, 334600, China
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  fullname: Santos, Heitor O.
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  surname: Qiu
  fullname: Qiu, Zhiyun
  email: xuanxun0203@sina.com
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Keywords Glucose
Walnut
HbA1c
Insulin
Leptin
Adiponectin
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Snippet •The walnut administration significant increasing serum leptin and adiponectin.•The walnut administration did not changes in fasting blood glucose (FBG).•The...
Background & objective: Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and...
Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic...
Highlights: The walnut administration significant increasing serum leptin and adiponectin. The walnut administration did not changes in fasting blood glucose...
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SubjectTerms Adiponectin
Bias
Biomarkers
Blood glucose
Clinical trials
Diabetes
Dietary intake
Fatty acids
Glucose
HbA1c
Hemoglobin
Hyperglycemia
Insulin
Insulin resistance
Investigations
Leptin
Meta-analysis
Metabolism
Sensitivity analysis
Systematic review
Walnut
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Title Walnut intake may increase circulating adiponectin and leptin levels but does not improve glycemic biomarkers: A systematic review and meta-analysis of randomized clinical trials
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