New in-situ synthetized hydrogel composite based on alginate and brushite as a potential pH sensitive drug delivery system

• Published in: Carbohydrate polymers Vol. 177; pp. 324 - 333
• Main Authors: Dabiri, Seyed Mohammad Hossein, Lagazzo, Alberto, Barberis, Fabrizio, Shayganpour, Amirreza, Finocchio, Elisabetta, Pastorino, Laura
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2017
• Subjects: Alginate; alginates; Alginates - chemistry; Brushite; Calcium Phosphates - chemistry; crosslinking; crystals; Drug delivery system; Drug Delivery Systems; Fourier transform infrared spectroscopy; hydrogels; Hydrogels - chemistry; Hydrogen-Ion Concentration; Ibuprofen; Ibuprofen - administration & dosage; In-situ hydrogel composite; mechanical properties; Microscopy, Electron, Scanning; pH sensitive; polymers; scanning electron microscopy; Spectroscopy, Fourier Transform Infrared; X-ray diffraction; Brushite; pH sensitive; In-situ hydrogel composite; Alginate; Drug delivery system; Ibuprofen

•Ibuprofen was loaded on the in-situ synthetized Alginate-brushite hydrogel beads.•Transformation of Na-ibuprofen to its acidic form occurred within the loading procedure.•The brushite within alginate matrix improved mechanical properties.•The brushite crystals restricted swelling behavior of algina...