New in-situ synthetized hydrogel composite based on alginate and brushite as a potential pH sensitive drug delivery system

•Ibuprofen was loaded on the in-situ synthetized Alginate-brushite hydrogel beads.•Transformation of Na-ibuprofen to its acidic form occurred within the loading procedure.•The brushite within alginate matrix improved mechanical properties.•The brushite crystals restricted swelling behavior of algina...

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Published inCarbohydrate polymers Vol. 177; pp. 324 - 333
Main Authors Dabiri, Seyed Mohammad Hossein, Lagazzo, Alberto, Barberis, Fabrizio, Shayganpour, Amirreza, Finocchio, Elisabetta, Pastorino, Laura
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2017
Subjects
Alginate
alginates
Alginates - chemistry
Brushite
Calcium Phosphates - chemistry
crosslinking
crystals
Drug delivery system
Drug Delivery Systems
Fourier transform infrared spectroscopy
hydrogels
Hydrogels - chemistry
Hydrogen-Ion Concentration
Ibuprofen
Ibuprofen - administration & dosage
In-situ hydrogel composite
mechanical properties
Microscopy, Electron, Scanning
pH sensitive
polymers
scanning electron microscopy
Spectroscopy, Fourier Transform Infrared
X-ray diffraction
Brushite
pH sensitive
In-situ hydrogel composite
Alginate
Drug delivery system
Ibuprofen
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Abstract •Ibuprofen was loaded on the in-situ synthetized Alginate-brushite hydrogel beads.•Transformation of Na-ibuprofen to its acidic form occurred within the loading procedure.•The brushite within alginate matrix improved mechanical properties.•The brushite crystals restricted swelling behavior of alginate.•The hydrogel composite beads released ibuprofen in a controlled manner. A Series of in-situ alginate-brushite (Alg-Bru) hydrogel composites were fabricated to optimize release profile of ibuprofen (Ibu) and to avoid burst releases associated with the pure form of the hydrogels. The Bru crystals were synthetized and dispersed during the crosslinking process of Alg matrix. The beads with different formulations were subject to various characterization tests such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), and swelling. In addition, the entrapment Efficiency (%EE) and drug release profile were obtained to investigate the impacts of initial concentration of Alg and content of Bru on these parameters. FTIR and XRD outcomes confirmed the successful fabricating of Alg-Bru composite as well as the loading of Ibu. Besides, the results showed that the presence of Bru within Alg matrix restricted polymer chain movement, improved mechanical properties, and decreased swelling ratio. Although the presence of Bru crystals did not improve%EE, they optimized the release profile in a more gradual manner.
AbstractList A Series of in-situ alginate-brushite (Alg-Bru) hydrogel composites were fabricated to optimize release profile of ibuprofen (Ibu) and to avoid burst releases associated with the pure form of the hydrogels. The Bru crystals were synthetized and dispersed during the crosslinking process of Alg matrix. The beads with different formulations were subject to various characterization tests such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), and swelling. In addition, the entrapment Efficiency (%EE) and drug release profile were obtained to investigate the impacts of initial concentration of Alg and content of Bru on these parameters. FTIR and XRD outcomes confirmed the successful fabricating of Alg-Bru composite as well as the loading of Ibu. Besides, the results showed that the presence of Bru within Alg matrix restricted polymer chain movement, improved mechanical properties, and decreased swelling ratio. Although the presence of Bru crystals did not improve%EE, they optimized the release profile in a more gradual manner.
•Ibuprofen was loaded on the in-situ synthetized Alginate-brushite hydrogel beads.•Transformation of Na-ibuprofen to its acidic form occurred within the loading procedure.•The brushite within alginate matrix improved mechanical properties.•The brushite crystals restricted swelling behavior of alginate.•The hydrogel composite beads released ibuprofen in a controlled manner. A Series of in-situ alginate-brushite (Alg-Bru) hydrogel composites were fabricated to optimize release profile of ibuprofen (Ibu) and to avoid burst releases associated with the pure form of the hydrogels. The Bru crystals were synthetized and dispersed during the crosslinking process of Alg matrix. The beads with different formulations were subject to various characterization tests such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), and swelling. In addition, the entrapment Efficiency (%EE) and drug release profile were obtained to investigate the impacts of initial concentration of Alg and content of Bru on these parameters. FTIR and XRD outcomes confirmed the successful fabricating of Alg-Bru composite as well as the loading of Ibu. Besides, the results showed that the presence of Bru within Alg matrix restricted polymer chain movement, improved mechanical properties, and decreased swelling ratio. Although the presence of Bru crystals did not improve%EE, they optimized the release profile in a more gradual manner.
A Series of in-situ alginate-brushite (Alg-Bru) hydrogel composites were fabricated to optimize release profile of ibuprofen (Ibu) and to avoid burst releases associated with the pure form of the hydrogels. The Bru crystals were synthetized and dispersed during the crosslinking process of Alg matrix. The beads with different formulations were subject to various characterization tests such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), and swelling. In addition, the entrapment Efficiency (%EE) and drug release profile were obtained to investigate the impacts of initial concentration of Alg and content of Bru on these parameters. FTIR and XRD outcomes confirmed the successful fabricating of Alg-Bru composite as well as the loading of Ibu. Besides, the results showed that the presence of Bru within Alg matrix restricted polymer chain movement, improved mechanical properties, and decreased swelling ratio. Although the presence of Bru crystals did not improve%EE, they optimized the release profile in a more gradual manner.A Series of in-situ alginate-brushite (Alg-Bru) hydrogel composites were fabricated to optimize release profile of ibuprofen (Ibu) and to avoid burst releases associated with the pure form of the hydrogels. The Bru crystals were synthetized and dispersed during the crosslinking process of Alg matrix. The beads with different formulations were subject to various characterization tests such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), and swelling. In addition, the entrapment Efficiency (%EE) and drug release profile were obtained to investigate the impacts of initial concentration of Alg and content of Bru on these parameters. FTIR and XRD outcomes confirmed the successful fabricating of Alg-Bru composite as well as the loading of Ibu. Besides, the results showed that the presence of Bru within Alg matrix restricted polymer chain movement, improved mechanical properties, and decreased swelling ratio. Although the presence of Bru crystals did not improve%EE, they optimized the release profile in a more gradual manner.
Author Dabiri, Seyed Mohammad Hossein
Barberis, Fabrizio
Lagazzo, Alberto
Pastorino, Laura
Shayganpour, Amirreza
Finocchio, Elisabetta
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  organization: Department of Informatics, Bioengineering, Robotics, and System Engineering, University of Genova, Via All'Opera Pia, 13−16145 Genova, Italy
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Keywords Brushite
pH sensitive
In-situ hydrogel composite
Alginate
Drug delivery system
Ibuprofen
Language English
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Snippet •Ibuprofen was loaded on the in-situ synthetized Alginate-brushite hydrogel beads.•Transformation of Na-ibuprofen to its acidic form occurred within the...
A Series of in-situ alginate-brushite (Alg-Bru) hydrogel composites were fabricated to optimize release profile of ibuprofen (Ibu) and to avoid burst releases...
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SubjectTerms Alginate
alginates
Alginates - chemistry
Brushite
Calcium Phosphates - chemistry
crosslinking
crystals
Drug delivery system
Drug Delivery Systems
Fourier transform infrared spectroscopy
hydrogels
Hydrogels - chemistry
Hydrogen-Ion Concentration
Ibuprofen
Ibuprofen - administration & dosage
In-situ hydrogel composite
mechanical properties
Microscopy, Electron, Scanning
pH sensitive
polymers
scanning electron microscopy
Spectroscopy, Fourier Transform Infrared
X-ray diffraction
Title New in-situ synthetized hydrogel composite based on alginate and brushite as a potential pH sensitive drug delivery system
URI https://dx.doi.org/10.1016/j.carbpol.2017.08.046
https://www.ncbi.nlm.nih.gov/pubmed/28962775
https://www.proquest.com/docview/1945221313
https://www.proquest.com/docview/2000556303
Volume 177
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