The effects of lithium on ex vivo cytokine production

• Published in: Biological psychiatry (1969) Vol. 50; no. 3; pp. 217 - 224
• Main Authors: Rapaport, Mark Hyman, Manji, Husseini K
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2001; Elsevier Science
• Subjects: Adult; Aged; Antipsychotic Agents - pharmacology; Biological and medical sciences; Bipolar Disorder - drug therapy; Bipolar Disorder - immunology; Bipolar Disorder - metabolism; Cells, Cultured; cyclic AMP; Cyclic AMP - metabolism; Cytokines; Cytokines - immunology; Cytokines - metabolism; Female; Humans; IL-2; immunology; lithium; Lithium - pharmacology; Male; Medical sciences; Middle Aged; myo-inositol; Neuropharmacology; Pharmacology. Drug treatments; Phosphoric Monoester Hydrolases - metabolism; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; lithium; cyclic AMP; IL-2; Cytokines; immunology; myo-inositol; Human; Cell culture; Immunomodulation; Secretion; Cytokine; Cyclic AMP; Lithium; In vitro; Biological activity; Interleukin 4; Ex vivo; Interleukin 2; Mood stabilizer; Interleukin 10; Production

Background: Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans. Methods: In this study, whole blood cultures from normal control subjects were established for 5 days and the effects of lithium on cytokine production were investigated. Becaus...