The effects of lithium on ex vivo cytokine production

Background: Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans. Methods: In this study, whole blood cultures from normal control subjects were established for 5 days and the effects of lithium on cytokine production were investigated. Becaus...

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Published inBiological psychiatry (1969) Vol. 50; no. 3; pp. 217 - 224
Main Authors Rapaport, Mark Hyman, Manji, Husseini K
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.08.2001
Elsevier Science
Subjects
Adult
Aged
Antipsychotic Agents - pharmacology
Biological and medical sciences
Bipolar Disorder - drug therapy
Bipolar Disorder - immunology
Bipolar Disorder - metabolism
Cells, Cultured
cyclic AMP
Cyclic AMP - metabolism
Cytokines
Cytokines - immunology
Cytokines - metabolism
Female
Humans
IL-2
immunology
lithium
Lithium - pharmacology
Male
Medical sciences
Middle Aged
myo-inositol
Neuropharmacology
Pharmacology. Drug treatments
Phosphoric Monoester Hydrolases - metabolism
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
lithium
cyclic AMP
IL-2
Cytokines
immunology
myo-inositol
Human
Cell culture
Immunomodulation
Secretion
Cytokine
Cyclic AMP
Lithium
In vitro
Biological activity
Interleukin 4
Ex vivo
Interleukin 2
Mood stabilizer
Interleukin 10
Production
Online AccessGet full text

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Abstract Background: Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans. Methods: In this study, whole blood cultures from normal control subjects were established for 5 days and the effects of lithium on cytokine production were investigated. Because many of lithium’s actions have been postulated to be modulated through phosphoinositide (PI), protein kinase C (PKC) and cyclic adenosine monophosphate (c-AMP) signaling pathways, the effects of myo-inositol and prostaglandin E 2, alone or in combination with lithium, were also investigated. Results: We found that lithium caused an increase in interleukin-4 and interleukin-10 levels, traditionally classified as T-helper lymphocyte type-2 cytokines, and a decrease in interleukin-2 and interferon-γ levels, traditionally classified as T-helper lymphocyte type-1 (TH-1) cytokines. This shift cannot be fully explained by lithium’s actions on the PI, PKC, or c-AMP messenger systems. Conclusions: Monocytes exposed to lithium in the presence of a mitogen for 5 days produced a shift toward the production of TH-2 cytokines and away from the production of TH-1 cytokines. The study suggests that lithium may have complex time-dependent effects on immune function.
AbstractList Background: Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans. Methods: In this study, whole blood cultures from normal control subjects were established for 5 days and the effects of lithium on cytokine production were investigated. Because many of lithium’s actions have been postulated to be modulated through phosphoinositide (PI), protein kinase C (PKC) and cyclic adenosine monophosphate (c-AMP) signaling pathways, the effects of myo-inositol and prostaglandin E 2, alone or in combination with lithium, were also investigated. Results: We found that lithium caused an increase in interleukin-4 and interleukin-10 levels, traditionally classified as T-helper lymphocyte type-2 cytokines, and a decrease in interleukin-2 and interferon-γ levels, traditionally classified as T-helper lymphocyte type-1 (TH-1) cytokines. This shift cannot be fully explained by lithium’s actions on the PI, PKC, or c-AMP messenger systems. Conclusions: Monocytes exposed to lithium in the presence of a mitogen for 5 days produced a shift toward the production of TH-2 cytokines and away from the production of TH-1 cytokines. The study suggests that lithium may have complex time-dependent effects on immune function.
Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans. In this study, whole blood cultures from normal control subjects were established for 5 days and the effects of lithium on cytokine production were investigated. Because many of lithium's actions have been postulated to be modulated through phosphoinositide (PI), protein kinase C (PKC) and cyclic adenosine monophosphate (c-AMP) signaling pathways, the effects of myo-inositol and prostaglandin E(2), alone or in combination with lithium, were also investigated. We found that lithium caused an increase in interleukin-4 and interleukin-10 levels, traditionally classified as T-helper lymphocyte type-2 cytokines, and a decrease in interleukin-2 and interferon-gamma levels, traditionally classified as T-helper lymphocyte type-1 (TH-1) cytokines. This shift cannot be fully explained by lithium's actions on the PI, PKC, or c-AMP messenger systems. Monocytes exposed to lithium in the presence of a mitogen for 5 days produced a shift toward the production of TH-2 cytokines and away from the production of TH-1 cytokines. The study suggests that lithium may have complex time-dependent effects on immune function.
Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans.BACKGROUNDStudies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans.In this study, whole blood cultures from normal control subjects were established for 5 days and the effects of lithium on cytokine production were investigated. Because many of lithium's actions have been postulated to be modulated through phosphoinositide (PI), protein kinase C (PKC) and cyclic adenosine monophosphate (c-AMP) signaling pathways, the effects of myo-inositol and prostaglandin E(2), alone or in combination with lithium, were also investigated.METHODSIn this study, whole blood cultures from normal control subjects were established for 5 days and the effects of lithium on cytokine production were investigated. Because many of lithium's actions have been postulated to be modulated through phosphoinositide (PI), protein kinase C (PKC) and cyclic adenosine monophosphate (c-AMP) signaling pathways, the effects of myo-inositol and prostaglandin E(2), alone or in combination with lithium, were also investigated.We found that lithium caused an increase in interleukin-4 and interleukin-10 levels, traditionally classified as T-helper lymphocyte type-2 cytokines, and a decrease in interleukin-2 and interferon-gamma levels, traditionally classified as T-helper lymphocyte type-1 (TH-1) cytokines. This shift cannot be fully explained by lithium's actions on the PI, PKC, or c-AMP messenger systems.RESULTSWe found that lithium caused an increase in interleukin-4 and interleukin-10 levels, traditionally classified as T-helper lymphocyte type-2 cytokines, and a decrease in interleukin-2 and interferon-gamma levels, traditionally classified as T-helper lymphocyte type-1 (TH-1) cytokines. This shift cannot be fully explained by lithium's actions on the PI, PKC, or c-AMP messenger systems.Monocytes exposed to lithium in the presence of a mitogen for 5 days produced a shift toward the production of TH-2 cytokines and away from the production of TH-1 cytokines. The study suggests that lithium may have complex time-dependent effects on immune function.CONCLUSIONSMonocytes exposed to lithium in the presence of a mitogen for 5 days produced a shift toward the production of TH-2 cytokines and away from the production of TH-1 cytokines. The study suggests that lithium may have complex time-dependent effects on immune function.
Author Rapaport, Mark Hyman
Manji, Husseini K
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Issue 3
Keywords lithium
cyclic AMP
IL-2
Cytokines
immunology
myo-inositol
Human
Cell culture
Immunomodulation
Secretion
Cytokine
Cyclic AMP
Lithium
In vitro
Biological activity
Interleukin 4
Ex vivo
Interleukin 2
Mood stabilizer
Interleukin 10
Production
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Snippet Background: Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans. Methods: In this study, whole blood...
Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans. In this study, whole blood cultures from normal...
Studies suggest that lithium may have profound immunomodulatory effects in animal models as well as in humans.BACKGROUNDStudies suggest that lithium may have...
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StartPage 217
SubjectTerms Adult
Aged
Antipsychotic Agents - pharmacology
Biological and medical sciences
Bipolar Disorder - drug therapy
Bipolar Disorder - immunology
Bipolar Disorder - metabolism
Cells, Cultured
cyclic AMP
Cyclic AMP - metabolism
Cytokines
Cytokines - immunology
Cytokines - metabolism
Female
Humans
IL-2
immunology
lithium
Lithium - pharmacology
Male
Medical sciences
Middle Aged
myo-inositol
Neuropharmacology
Pharmacology. Drug treatments
Phosphoric Monoester Hydrolases - metabolism
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Title The effects of lithium on ex vivo cytokine production
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0006322301011441
https://dx.doi.org/10.1016/S0006-3223(01)01144-1
https://www.ncbi.nlm.nih.gov/pubmed/11513821
https://www.proquest.com/docview/71148435
Volume 50
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