Induction of autoreactive B cells allows priming of autoreactive T cells
A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell...
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| Published in | The Journal of experimental medicine Vol. 173; no. 6; pp. 1433 - 1439 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Rockefeller University Press
01.06.1991
The Rockefeller University Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen. |
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| AbstractList | A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen. |
| Author | RONG-HWA LIN HARDIN, J. A MAMULA, M. J JANEWAY, C. A |
| Author_xml | – sequence: 1 surname: RONG-HWA LIN fullname: RONG-HWA LIN organization: Yale univ. school medicine, Howard Hughes inst., sect. immunobiology, New Haven CT 06510, United States – sequence: 2 givenname: M. J surname: MAMULA fullname: MAMULA, M. J organization: Yale univ. school medicine, Howard Hughes inst., sect. immunobiology, New Haven CT 06510, United States – sequence: 3 givenname: J. A surname: HARDIN fullname: HARDIN, J. A organization: Yale univ. school medicine, Howard Hughes inst., sect. immunobiology, New Haven CT 06510, United States – sequence: 4 givenname: C. A surname: JANEWAY fullname: JANEWAY, C. A organization: Yale univ. school medicine, Howard Hughes inst., sect. immunobiology, New Haven CT 06510, United States |
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| Keywords | Autoimmunity Antigen presentation Immunization Rodentia Activation B-Lymphocyte Xenogeneic system Antigen Cytochrome c Vertebrata Mammalia Autoantigen Mouse Immune tolerance T-Lymphocyte |
| Language | English |
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| Snippet | A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human... A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non- self protein... |
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| SubjectTerms | Animals Antibody Formation Antigen-Presenting Cells - immunology Autoimmunity - immunology B-Lymphocytes - immunology Biological and medical sciences Cytochrome c Group - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility Antigens Class II - immunology Immune Tolerance Immunobiology Immunological tolerance Lymphocyte Activation Mice Mice, Inbred Strains T-Lymphocytes - immunology |
| Title | Induction of autoreactive B cells allows priming of autoreactive T cells |
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