Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden

• Published in: Brain (London, England : 1878) Vol. 134; no. 6; pp. 1635 - 1646
• Main Authors: Drzezga, Alexander, Becker, J. Alex, Van Dijk, Koene R. A., Sreenivasan, Aishwarya, Talukdar, Tanveer, Sullivan, Caroline, Schultz, Aaron P., Sepulcre, Jorge, Putcha, Deepti, Greve, Doug, Johnson, Keith A., Sperling, Reisa A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2011
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Amyloid - metabolism; Benzothiazoles; Biological and medical sciences; Brain Mapping; Cerebral Cortex - blood supply; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Cognition Disorders - diagnostic imaging; Cognition Disorders - etiology; Cognition Disorders - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Neurology; Original; Oxygen - blood; Positron-Emission Tomography - methods; Statistics as Topic; Human; Nervous system diseases; magnetic resonance imaging; Cognitive disorder; Metabolism; Nuclear magnetic resonance imaging; functional connectivity; Dysfunction; cortical hubs; Amyloid; mild cognitive impairment; Positron emission tomography; Emission tomography
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/awr066

Disruption of functional connectivity between brain regions may represent an early functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease. We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional w...