Altered Glutathione Redox State in Schizophrenia

• Published in: Disease markers Vol. 22; no. 1-2; pp. 83 - 93
• Main Authors: Yao, Jeffrey K., Leonard, Sherry, Reddy, Ravinder
• Format: Journal Article
• Language: English
• Published: United States IOS Press 01.01.2006
• Subjects: Age Factors; Aged; Caudate Nucleus - chemistry; Female; Glutathione - metabolism; Glutathione Disulfide - analysis; Glutathione Reductase - analysis; Humans; Male; Middle Aged; Other; Oxidation-Reduction; Schizophrenia - metabolism; Sex Factors; Smoking - metabolism

Altered antioxidant status has been reported in schizophrenia. The glutathione (GSH) redox system is important for reducing oxidative stress. GSH, a radical scavenger, is converted to oxidized glutathione (GSSG) through glutathione peroxidase (GPx), and converted back to GSH by glutathione reductase...