Antioxidant and Anti-Aging Potential of Indian Sandalwood Oil against Environmental Stressors In Vitro and Ex Vivo

Distilled from the heartwood of Santalum album, Indian sandalwood oil is an essential oil that historically has been used as a natural active ingredient in cosmetics to condition and brighten the skin. It has been documented to exhibit antioxidant, anti-inflammatory, and anti-proliferative activitie...

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Published inCosmetics (Basel) Vol. 8; no. 2; p. 53
Main Authors Francois-Newton, Véronique, Brown, Andrew, Andres, Philippe, Mandary, Madiiha Bibi, Weyers, Carli, Latouche-Veerapen, Mélissa, Hettiarachchi, Dhanushka
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2021
Subjects
Aging
Antioxidants
Cigarette smoke
Cigarettes
Collagen
Collagenase
Cosmetics
Essential oils
ex vivo
Explants
exposomes
in vitro
Indian sandalwood oil
Inflammation
Interstitial collagenase
Light
Matrix metalloproteinase
Medical research
Oils & fats
Oxidative stress
Pollutants
Radiation
Reactive oxygen species
Santalaceae
Skin
Vitamin E
St Louis Missouri
United States > US
China
India
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Summary:Distilled from the heartwood of Santalum album, Indian sandalwood oil is an essential oil that historically has been used as a natural active ingredient in cosmetics to condition and brighten the skin. It has been documented to exhibit antioxidant, anti-inflammatory, and anti-proliferative activities. Here, we investigated the protective and anti-aging effects of Indian sandalwood oil in scavenging reactive oxygen species (ROS) in HaCaT cells and in human skin explants after exposure to oxidative stress. Using a probe DCFH-DA, the antioxidant capacity of Indian sandalwood oil was monitored following exposure to blue light at 412 nm and 450 nm or cigarette smoke. The anti-aging effect of sandalwood oil was also explored in human skin explants via the assessment of collagenase level (MMP-1). We reported that Indian sandalwood oil possessed antioxidant potential that can scavenge the ROS generated by a free radical generating compound (AAPH). Subsequent exposure to environmental stressors revealed that Indian sandalwood oil possessed superior antioxidant activity in comparison to vitamin E (alpha tocopherol). Using human skin explants, this study demonstrated that Indian sandalwood oil can also inhibit the pollutant-induced level of MMP-1. The findings indicated that Indian sandalwood oil can potentially serve as a protective and anti-aging active ingredient in cosmetics and dermatology against environmental stressors.
ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics8020053