Decreased progesterone receptor expression in the intermediate trophoblastic cells of spontaneous abortions

• Published in: Fertility and sterility Vol. 77; no. 5; pp. 1001 - 1005
• Main Authors: Hickman, Timothy N, Shih, Le-Ming, Zacur, Howard A, Kurman, Robert J, Diener-West, Marie, Gearhart, John D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2002; Elsevier Science
• Subjects: Abortion, Induced; Abortion, Spontaneous - metabolism; Abortion, Spontaneous - pathology; Adult; Antigens, CD; Biological and medical sciences; CD146 Antigen; Diseases of mother, fetus and pregnancy; Female; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; intermediate trophoblast; Medical sciences; Membrane Glycoproteins - metabolism; Neural Cell Adhesion Molecules; Pregnancy; Pregnancy. Fetus. Placenta; Progesterone receptor; Receptors, Progesterone - metabolism; spontaneous abortion; Staining and Labeling; Trophoblasts - cytology; Trophoblasts - metabolism; spontaneous abortion; immunohistochemistry; Progesterone receptor; intermediate trophoblast; Human; Trophoblaste; Pregnancy disorders; Fetal membrane; Biological marker; Female; Progesterone; Sex steroid hormone; Gene expression; Abortion; Ovarian hormone; Hormonal receptor

Objective: To determine whether there are differences in the expression of progesterone receptor (PR) in intermediate trophoblastic cells of pregnancies ending in either spontaneous abortion (SAB) or elective abortion. Design: Immunohistochemical identification of PR in intermediate trophoblastic ce...