Serology of antibodies to second- and third-generation cephalosporins associated with immune hemolytic anemia and/or positive direct antiglobulin tests

• Published in: Transfusion (Philadelphia, Pa.) Vol. 39; no. 11; pp. 1239 - 1246
• Main Authors: Arndt, P.A., Leger, R.M., Garratty, G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.11.1999; Blackwell Publishing
• Subjects: Anemia, Hemolytic, Autoimmune - blood; Anemia, Hemolytic, Autoimmune - chemically induced; Anemia, Hemolytic, Autoimmune - immunology; Antibodies - blood; Biological and medical sciences; Cefotetan - immunology; Ceftriaxone - immunology; Cephalosporins - immunology; Coombs Test; DAT = direct antiglobulin test; Drug toxicity and drugs side effects treatment; Humans; IAT = indirect antiglobulin test; IHA = immune hemolytic anemia; LISS = low-ionic-strength saline; Medical sciences; PBS = phosphate-buffered saline; PEG = polyethylene glycol; Pharmacology. Drug treatments; RBC(s) = red cell(s); Toxicity: blood; Human; Toxicity; β-Lactams; Hemopathy; Serology; Monoclonal antibody; Ceftriaxone; Antibiotic; Cefotetan; Cephalosporin derivatives; Sensitivity; Hemolytic anemia; Complication; Diagnostic aid

BACKGROUND: First‐generation cephalosporins rarely caused immune hemolytic anemia (IHA). Second‐ and third‐generation cephalosporins, especially cefotetan and ceftriaxone, are increasingly associated with severe, sometimes fatal IHA. STUDY DESIGN AND METHODS: Samples from 53 patients with drug‐induc...