Possible role of Hes5 for the rostrocaudal polarity formation of the tectum
The alar plate of the mesencephalon differentiates into the optic tectum. Retinal fibers project to the tectum topographically in a retinotopic manner. Engrailed (En) is responsible for the tectum polarity formation and regionalization. Former study indicated the presence of the molecule whose expre...
Saved in:
Published in | Development, growth & differentiation Vol. 46; no. 3; pp. 219 - 227 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science, Ltd
01.06.2004
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The alar plate of the mesencephalon differentiates into the optic tectum. Retinal fibers project to the tectum topographically in a retinotopic manner. Engrailed (En) is responsible for the tectum polarity formation and regionalization. Former study indicated the presence of the molecule whose expression is repressed by En and that represses the isthmus‐related gene expression. To isolate such molecules, we constructed a subtracted library between cDNA population of the normal rostral mesencephalon and of the rostral mesencephalon that misexpresses En2. From the library, we isolated cHes5, a chicken homolog of Drosophila hairy/Enhancer of split. cHes5 begins to be expressed in the rostral part of the E2 mesencephalon, and spreads to caudal mesencephalon by E3. To our expectation, cHes5 expression was repressed by En2. Furthermore, misexpression of cHes5 in the mesencephalon inhibited expression of ephrinA2, a marker of caudal mesencephalon. An active repressor form of Hes5, which is a chimeric molecule of Hes5 and repressor domain of En2, showed a similar but more severe phenotype. The results indicate that Hes5 is regulated by En and is responsible for rostral identity of mesencephalon by repressing ephrinA2. |
---|---|
AbstractList | The alar plate of the mesencephalon differentiates into the optic tectum. Retinal fibers project to the tectum topographically in a retinotopic manner. Engrailed (En) is responsible for the tectum polarity formation and regionalization. Former study indicated the presence of the molecule whose expression is repressed by En and that represses the isthmus-related gene expression. To isolate such molecules, we constructed a subtracted library between cDNA population of the normal rostral mesencephalon and of the rostral mesencephalon that misexpresses En2. From the library, we isolated cHes5, a chicken homolog of Drosophila hairy/Enhancer of split. cHes5 begins to be expressed in the rostral part of the E2 mesencephalon, and spreads to caudal mesencephalon by E3. To our expectation, cHes5 expression was repressed by En2. Furthermore, misexpression of cHes5 in the mesencephalon inhibited expression of ephrinA2, a marker of caudal mesencephalon. An active repressor form of Hes5, which is a chimeric molecule of Hes5 and repressor domain of En2, showed a similar but more severe phenotype. The results indicate that Hes5 is regulated by En and is responsible for rostral identity of mesencephalon by repressing ephrinA2. The alar plate of the mesencephalon differentiates into the optic tectum. Retinal fibers project to the tectum topographically in a retinotopic manner. Engrailed ( En ) is responsible for the tectum polarity formation and regionalization. Former study indicated the presence of the molecule whose expression is repressed by En and that represses the isthmus‐related gene expression. To isolate such molecules, we constructed a subtracted library between cDNA population of the normal rostral mesencephalon and of the rostral mesencephalon that misexpresses En2. From the library, we isolated cHes5 , a chicken homolog of Drosophila hairy/Enhancer of split . cHes5 begins to be expressed in the rostral part of the E2 mesencephalon, and spreads to caudal mesencephalon by E3. To our expectation, cHes5 expression was repressed by En2. Furthermore, misexpression of cHes5 in the mesencephalon inhibited expression of ephrinA2 , a marker of caudal mesencephalon. An active repressor form of Hes5, which is a chimeric molecule of Hes5 and repressor domain of En2, showed a similar but more severe phenotype. The results indicate that Hes5 is regulated by En and is responsible for rostral identity of mesencephalon by repressing ephrinA2 . |
Author | Nakamura, Harukazu Araki, Isato Kimura, Jun Katahira, Tatsuya |
Author_xml | – sequence: 1 givenname: Jun surname: Kimura fullname: Kimura, Jun – sequence: 2 givenname: Tatsuya surname: Katahira fullname: Katahira, Tatsuya – sequence: 3 givenname: Isato surname: Araki fullname: Araki, Isato – sequence: 4 givenname: Harukazu surname: Nakamura fullname: Nakamura, Harukazu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15206953$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkFtLwzAUgINM3EX_gvTJt9bc2ibgi2y6iQN9UPAtpGmKHW0zkxa3f2_ihj5qAkk45zvnkG8KRp3pNAARggny63qTIEphjDL-lmAIaQJhTniyOwGTn8QITCBEOEYpx2MwdW4DPUkRPgNjlGKY8ZRMwOOzca4uGh1Z4w9TRSvt0qgyNurfQ9D11ig5lLKJtqaRtu73IdvKvjZd4APWa9UP7Tk4rWTj9MXxnoHX-7uX-SpePy0f5rfrWFGa8phVUMmcQyqrUpOiRJgRTf1mmjKOqWJSEx_SeUUJQbjMuVI5UhJSzHlRkRm4OvTdWvMxaNeLtnZKN43stBmcyLKMcM6yP0HEIPITmQfZAVT-w87qSmxt3Uq7FwiKYFxsRBArglgRjItv42LnSy-PM4ai1eVv4VGxB24OwGfd6P2_G4vFcuEf5Aukt5EE |
CitedBy_id | crossref_primary_10_1016_j_ydbio_2007_01_032 crossref_primary_10_1186_s12861_017_0159_8 crossref_primary_10_1371_journal_pone_0084617 crossref_primary_10_3389_fnana_2022_826976 crossref_primary_10_3389_fcell_2020_586158 crossref_primary_10_1016_j_jtbi_2007_07_026 crossref_primary_10_1016_j_mod_2004_05_013 |
Cites_doi | 10.1016/0896-6273(92)90099-Y 10.1002/dvg.1020130505 10.1016/0092-8674(95)90425-5 10.1016/S0092-8674(00)80150-6 10.1128/MCB.15.12.6923 10.1074/jbc.270.3.1342 10.1128/MCB.16.6.2670 10.1006/dbio.2000.9643 10.1242/dev.122.10.3141 10.1016/0922-3371(90)90120-L 10.1006/bbrc.2002.6483 10.1006/bbrc.1996.0959 10.1016/S0925-4773(96)00634-X 10.1242/dev.126.22.5127 10.1016/0092-8674(95)90426-3 10.1038/363038a0 10.1016/S0896-6273(00)80023-9 10.1016/S0960-9822(02)00645-0 10.1016/0092-8674(89)90682-X 10.1016/S0165-3806(99)00073-5 10.1002/(SICI)1521-1878(199804)20:4<298::AID-BIES6>3.0.CO;2-M 10.1523/JNEUROSCI.16-17-05498.1996 10.1046/j.1440-169X.1998.00005.x 10.1074/jbc.M102420200 10.1242/dev.113.4.1133 10.1046/j.1440-169X.1997.t01-4-00012.x 10.1016/0092-8674(94)90070-1 10.1128/MCB.13.9.5216 10.1046/j.1440-169X.2003.00705.x 10.1016/0092-8674(89)90947-1 10.1242/dev.127.11.2357 10.1093/emboj/16.6.1258 10.1093/emboj/18.8.2196 10.1242/dev.124.10.1953 10.1002/jnr.490210234 10.1046/j.1440-169x.1999.00401.x 10.1002/jmor.1050880104 10.1016/S0021-9258(19)36694-3 10.1016/S0168-0102(96)01151-0 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TK 8FD FR3 P64 RC3 7X8 |
DOI | 10.1111/j.1440-169X.2004.00739.x |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Neurosciences Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Engineering Research Database Technology Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitleList | Genetics Abstracts MEDLINE - Academic MEDLINE CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Zoology Biology |
EISSN | 1440-169X |
EndPage | 227 |
ExternalDocumentID | 10_1111_j_1440_169X_2004_00739_x 15206953 DGD739 |
Genre | article Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -~X .3N .GA .Y3 05W 0R~ 10A 1OC 24P 29F 2WC 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5HH 5LA 5VS 66C 7.U 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ACAHQ ACCFJ ACCZN ACGFS ACNCT ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFZJQ AHBTC AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AUFTA AZBYB AZVAB BAFTC BAWUL BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BY8 C45 CAG COF CS3 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRSTM DU5 E3Z EAD EAP EBC EBD EBS EJD EMB EMK EMOBN EST ESX F00 F01 F04 F5P FIJ G-S G.N GODZA H.T H.X HF~ HGLYW HZI HZ~ IHE IX1 J0M K48 LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ O66 O9- OBS OIG OK1 OVD P2P P2W P2X P4D Q.N Q11 QB0 R.K ROL RWI RX1 SUPJJ SV3 TEORI TN5 TUS UB1 W8V W99 WBKPD WH7 WIH WIK WIN WNSPC WOHZO WQJ WRC WXSBR WYISQ XG1 XV2 ZCG ZZTAW ~IA ~KM ~WT CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TK 8FD FR3 P64 RC3 7X8 |
ID | FETCH-LOGICAL-c4459-8f0ca7904afde3bd1283e4e4e8e48924c8ae383ee7f43312d79cc71ca04299bf3 |
IEDL.DBID | DR2 |
ISSN | 0012-1592 |
IngestDate | Fri Aug 16 05:04:05 EDT 2024 Wed Jul 24 14:57:15 EDT 2024 Fri Aug 23 01:37:08 EDT 2024 Sat Sep 28 07:42:51 EDT 2024 Sat Aug 24 00:50:24 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4459-8f0ca7904afde3bd1283e4e4e8e48924c8ae383ee7f43312d79cc71ca04299bf3 |
Notes | These two authors contributed equally ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-169X.2004.00739.x |
PMID | 15206953 |
PQID | 18018928 |
PQPubID | 23462 |
PageCount | 9 |
ParticipantIDs | proquest_miscellaneous_66639986 proquest_miscellaneous_18018928 crossref_primary_10_1111_j_1440_169X_2004_00739_x pubmed_primary_15206953 wiley_primary_10_1111_j_1440_169X_2004_00739_x_DGD739 |
PublicationCentury | 2000 |
PublicationDate | June 2004 2004-Jun 2004-06-00 20040601 |
PublicationDateYYYYMMDD | 2004-06-01 |
PublicationDate_xml | – month: 06 year: 2004 text: June 2004 |
PublicationDecade | 2000 |
PublicationPlace | Oxford, UK |
PublicationPlace_xml | – name: Oxford, UK – name: Japan |
PublicationTitle | Development, growth & differentiation |
PublicationTitleAlternate | Dev Growth Differ |
PublicationYear | 2004 |
Publisher | Blackwell Science, Ltd |
Publisher_xml | – name: Blackwell Science, Ltd |
References | 1997; 62 1991; 113 2002; 291 1995; 15 1992; 267 1998 1992.; 8 1951; 88 1997; 27 1992; 13 1996; 122 1999; 41 1998; 40 1999; 126 1996; 16 1996; 223 1998; 20 1993; 363 1995; 270 2001; 276 1997; 124 1993; 13 1995; 82 1989; 56 1999; 18 1990; 29 1988; 21 1997; 39 1997; 16 1994; 79 2000; 221 2003.; 45 1999; 116 1989; 58 1996; 86 1996; 6 2000.; 127 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_14_1 e_1_2_6_34_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_16_1 e_1_2_6_37_1 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_41_1 Itasaki N. (e_1_2_6_17_1) 1991; 113 e_1_2_6_9_1 Matsunaga E. (e_1_2_6_23_1) 2000; 127 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 Stern C. D. (e_1_2_6_35_1) 1998 Wakamatsu Y. (e_1_2_6_40_1) 1997; 124 e_1_2_6_6_1 e_1_2_6_25_1 Friedman G. C. (e_1_2_6_11_1) 1996; 16 e_1_2_6_24_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 Araki I. (e_1_2_6_3_1) 1999; 126 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
References_xml | – volume: 16 start-page: 5498 year: 1996 end-page: 5509 article-title: Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons publication-title: J. Neurosci. – volume: 29 start-page: 181 year: 1990 end-page: 186 article-title: A mouse embryonic stem cell line showing pluripotency of differentiation in early embryos and ubiquitous beta‐galactosidase expression publication-title: Cell. Differ. Dev. – volume: 16 start-page: 55 year: 1996 end-page: 62 article-title: A role for gradient en expression in positional specification on the optic tectum publication-title: Neuron – volume: 16 start-page: 1258 year: 1997 end-page: 1267 article-title: Shared and distinct functions of RAGS and ELF‐1 in guiding retinal axons publication-title: EMBO J. – volume: 86 start-page: 755 year: 1996 end-page: 766 article-title: Topographically specific effects of ELF‐1 on retinal axon guidance in vitro and retinal axon mapping in vivo publication-title: Cell – volume: 62 start-page: 3 year: 1997 end-page: 13 article-title: A chick wingless mutation causes abnormality in maintenance of Fgf8 expression in the wing apical ridge, resulting in loss of the dorsoventral boundary publication-title: Mech. Dev. – volume: 126 start-page: 5127 year: 1999 end-page: 5135 article-title: Engrailed defines the position of dorsal di–mesencephalic boundary by repressing diencephalic fate publication-title: Development – volume: 40 start-page: 157 year: 1998 end-page: 166 article-title: Crossregulation between En‐2 and Wnt‐1 in chick tectal development publication-title: Dev. Growth Differ. – volume: 363 start-page: 38 year: 1993 end-page: 45 article-title: Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain publication-title: Nature – volume: 88 start-page: 35 year: 1951 end-page: 46 article-title: A series of normal stages in the development of the chick embryo publication-title: J. Morph. – volume: 15 start-page: 6923 year: 1995 end-page: 6931 article-title: Specificity for the hairy/enhancer of split basic helix‐loop‐helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression publication-title: Mol. Cell. Biol. – volume: 16 start-page: 2670 year: 1996 end-page: 2677 article-title: The WRPW motif of the hairy‐related basic helix‐loop‐helix repressor proteins acts as a 4‐amino‐acid transcription repression and protein–protein interaction domain publication-title: Mol. Cell. Biol. – volume: 13 start-page: 345 year: 1992 end-page: 358 article-title: Cloning and sequence comparison of the mouse, human, and chick engrailed genes reveal potential functional domains and regulatory regions publication-title: Dev. Genet. – volume: 13 start-page: 5216 year: 1993 end-page: 5224 article-title: Binding of myc proteins to canonical and noncanonical DNA sequences publication-title: Mol. Cell. Biol. – volume: 79 start-page: 805 year: 1994 end-page: 815 article-title: Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy‐related bHLH proteins publication-title: Cell – volume: 27 start-page: 211 year: 1997 end-page: 217 article-title: En‐2 regulates the expression of the ligands for Eph type tyrosine kinases in chick embryonic tectum publication-title: Neurosci. Res. – volume: 82 start-page: 371 year: 1995 end-page: 381 article-title: Complementary gradients in expression and binding of Elf‐1 and Mek4 in development of the topographic retinotectal projection map publication-title: Cell – volume: 127 start-page: 2357 year: 2000. end-page: 2365 article-title: Pax6 defines the di‐mesencephalic boundary by repressing and publication-title: Development – volume: 20 start-page: 298 year: 1998 end-page: 306 article-title: The function of hairy‐related bHLH repressor proteins in cell fate decisions publication-title: Bioessays – volume: 56 start-page: 777 year: 1989 end-page: 783 article-title: A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins publication-title: Cell – volume: 8 start-page: 787 year: 1992. end-page: 798 article-title: Rostrocaudal polarity of tectum in birds: Correlation of en gradient and topographic order in retinotectal projection publication-title: Neuron. – volume: 18 start-page: 2196 year: 1999 end-page: 2207 article-title: Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation publication-title: EMBO J. – volume: 58 start-page: 955 year: 1989 end-page: 968 article-title: Expression of engrailed proteins in arthropods, annelids, and chordates publication-title: Cell – volume: 41 start-page: 59 year: 1999 end-page: 72 article-title: Role of Pax‐5 in the regulation of a mid‐hindbrain organizer's activity publication-title: Dev. Growth Differ. – volume: 116 start-page: 41 year: 1999 end-page: 49 article-title: Roles of Pax‐2 in initiation of the chick tectal development publication-title: Dev. Brain Res. – volume: 221 start-page: 168 year: 2000 end-page: 180 article-title: Antagonizing activity of chick Grg4 against tectum‐organizing activity publication-title: Dev. Biol. – volume: 113 start-page: 1133 year: 1991 end-page: 1144 article-title: Establishment of rostrocaudal polarity in tectal primordium – engrailed expression and subsequent tectal polarity publication-title: Development – volume: 291 start-page: 582 year: 2002 end-page: 587 article-title: Hes‐1, a known transcriptional repressor, acts as a transcriptional activator for the fuman acid a‐glucosidase in human fibroblast cells publication-title: Biochem. Biophys. Res. Commun. – volume: 223 start-page: 701 year: 1996 end-page: 705 article-title: Molecular interaction between TLE1 and the carboxyl‐terminal domain of HES‐1 containing the WRPW motif publication-title: Biochem. Biophys. Res. Commun. – volume: 21 start-page: 426 year: 1988 end-page: 437 article-title: Expression of an engrailed‐like gene during development of the early embryonic chick nervous system publication-title: J. Neurosci. Res. – volume: 270 start-page: 1342 year: 1995 end-page: 1349 article-title: Structure and promoter analysis of the gene encoding the mouse helix‐loop‐helix factor Hes‐5 – identification of the neural precursor cell‐specific promoter element publication-title: J. Biol. Chem. – volume: 122 start-page: 3141 year: 1996 end-page: 3150 article-title: A conserved region of engrailed, shared among all en‐, gsc‐, Nk1‐, Nk2‐ and msh‐class homeoproteins, mediates active transcriptional repression in vivo publication-title: Development – volume: 267 start-page: 21879 year: 1992 end-page: 21885 article-title: Molecular characterization of a rat negative regulator with a basic helix‐loop‐helix structure predominantly expressed in the developing nervous system publication-title: J. Biol. Chem. – volume: 6 start-page: 1006 year: 1996 end-page: 1014 article-title: Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression publication-title: Curr. Biol. – volume: 45 start-page: 361 year: 2003. end-page: 367 article-title: Gene silencing in chick embryos with vector‐based small interfering RNA system publication-title: Develop. Growth Differ. – volume: 82 start-page: 359 year: 1995 end-page: 370 article-title: In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases publication-title: Cell – volume: 39 start-page: 643 year: 1997 end-page: 653 article-title: Early specification of intestinal epithelium in the chick embryo: a study on the localization and regulation of CdxA expression publication-title: Dev. Growth Differ. – volume: 276 start-page: 30467 year: 2001 end-page: 30474 article-title: Roles of the basic helix‐loop‐helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain publication-title: J. Biol. Chem. – start-page: 223 year: 1998 end-page: 243 – volume: 124 start-page: 1953 year: 1997 end-page: 1962 article-title: Regulation of the neural crest fate by N‐myc: promotion of ventral migration and neuronal differentiation publication-title: Development – ident: e_1_2_6_18_1 doi: 10.1016/0896-6273(92)90099-Y – ident: e_1_2_6_21_1 doi: 10.1002/dvg.1020130505 – ident: e_1_2_6_7_1 doi: 10.1016/0092-8674(95)90425-5 – ident: e_1_2_6_26_1 doi: 10.1016/S0092-8674(00)80150-6 – ident: e_1_2_6_6_1 doi: 10.1128/MCB.15.12.6923 – ident: e_1_2_6_39_1 doi: 10.1074/jbc.270.3.1342 – ident: e_1_2_6_10_1 doi: 10.1128/MCB.16.6.2670 – ident: e_1_2_6_38_1 doi: 10.1006/dbio.2000.9643 – ident: e_1_2_6_34_1 doi: 10.1242/dev.122.10.3141 – ident: e_1_2_6_36_1 doi: 10.1016/0922-3371(90)90120-L – ident: e_1_2_6_41_1 doi: 10.1006/bbrc.2002.6483 – ident: e_1_2_6_14_1 doi: 10.1006/bbrc.1996.0959 – ident: e_1_2_6_29_1 doi: 10.1016/S0925-4773(96)00634-X – volume: 126 start-page: 5127 year: 1999 ident: e_1_2_6_3_1 article-title: Engrailed defines the position of dorsal di–mesencephalic boundary by repressing diencephalic fate publication-title: Development doi: 10.1242/dev.126.22.5127 contributor: fullname: Araki I. – ident: e_1_2_6_5_1 doi: 10.1016/0092-8674(95)90426-3 – ident: e_1_2_6_8_1 doi: 10.1038/363038a0 – ident: e_1_2_6_19_1 doi: 10.1016/S0896-6273(00)80023-9 – ident: e_1_2_6_22_1 doi: 10.1016/S0960-9822(02)00645-0 – ident: e_1_2_6_25_1 doi: 10.1016/0092-8674(89)90682-X – ident: e_1_2_6_30_1 doi: 10.1016/S0165-3806(99)00073-5 – ident: e_1_2_6_9_1 doi: 10.1002/(SICI)1521-1878(199804)20:4<298::AID-BIES6>3.0.CO;2-M – volume: 16 start-page: 5498 year: 1996 ident: e_1_2_6_11_1 article-title: Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.16-17-05498.1996 contributor: fullname: Friedman G. C. – ident: e_1_2_6_37_1 doi: 10.1046/j.1440-169X.1998.00005.x – ident: e_1_2_6_28_1 doi: 10.1074/jbc.M102420200 – volume: 113 start-page: 1133 year: 1991 ident: e_1_2_6_17_1 article-title: Establishment of rostrocaudal polarity in tectal primordium – engrailed expression and subsequent tectal polarity publication-title: Development doi: 10.1242/dev.113.4.1133 contributor: fullname: Itasaki N. – ident: e_1_2_6_16_1 doi: 10.1046/j.1440-169X.1997.t01-4-00012.x – ident: e_1_2_6_31_1 doi: 10.1016/0092-8674(94)90070-1 – ident: e_1_2_6_4_1 doi: 10.1128/MCB.13.9.5216 – ident: e_1_2_6_20_1 doi: 10.1046/j.1440-169X.2003.00705.x – ident: e_1_2_6_32_1 doi: 10.1016/0092-8674(89)90947-1 – start-page: 223 volume-title: Cellular and Molecular Procedures in Developmental Biology year: 1998 ident: e_1_2_6_35_1 contributor: fullname: Stern C. D. – volume: 127 start-page: 2357 year: 2000 ident: e_1_2_6_23_1 article-title: Pax6 defines the di‐mesencephalic boundary by repressing En1 and Pax2 publication-title: Development doi: 10.1242/dev.127.11.2357 contributor: fullname: Matsunaga E. – ident: e_1_2_6_24_1 doi: 10.1093/emboj/16.6.1258 – ident: e_1_2_6_27_1 doi: 10.1093/emboj/18.8.2196 – volume: 124 start-page: 1953 year: 1997 ident: e_1_2_6_40_1 article-title: Regulation of the neural crest fate by N‐myc: promotion of ventral migration and neuronal differentiation publication-title: Development doi: 10.1242/dev.124.10.1953 contributor: fullname: Wakamatsu Y. – ident: e_1_2_6_13_1 doi: 10.1002/jnr.490210234 – ident: e_1_2_6_12_1 doi: 10.1046/j.1440-169x.1999.00401.x – ident: e_1_2_6_15_1 doi: 10.1002/jmor.1050880104 – ident: e_1_2_6_2_1 doi: 10.1016/S0021-9258(19)36694-3 – ident: e_1_2_6_33_1 doi: 10.1016/S0168-0102(96)01151-0 |
SSID | ssj0004412 |
Score | 1.7325199 |
Snippet | The alar plate of the mesencephalon differentiates into the optic tectum. Retinal fibers project to the tectum topographically in a retinotopic manner.... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 219 |
SubjectTerms | Amino Acid Sequence Animals chick Chick Embryo Cloning, Molecular DNA, Complementary DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Electroporation engrailed Ephrin-A2 - genetics Gallus gallus Gene Expression Profiling Gene Expression Regulation, Developmental Gene Library Hes5 Homeodomain Proteins - physiology in ovo electroporation In Situ Hybridization mesencephalon Mesencephalon - embryology Mesencephalon - metabolism Molecular Sequence Data Repressor Proteins - genetics Repressor Proteins - physiology Sequence Homology, Amino Acid Superior Colliculi - embryology Superior Colliculi - metabolism tectum |
Title | Possible role of Hes5 for the rostrocaudal polarity formation of the tectum |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1440-169X.2004.00739.x https://www.ncbi.nlm.nih.gov/pubmed/15206953 https://search.proquest.com/docview/18018928 https://search.proquest.com/docview/66639986 |
Volume | 46 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT8MwDLYQCIkL78d45sC1U7umjx2BMSYQCCGQJi5VkjoXYJ3YJgG_HjvdBhsgIYR68SFNk7iOvy9xHIDDIEkwjKSh2Q-lJy2SzdWM9dLQxkqFNo9dOobLq7h1J8_bUXsY_8RnYcr8EOMFN7YMN1-zgSvdmzJy3peM621H86pu06nKeJLz6jE-uvnIJEVev0wcHtQ88uBTQT3fVjTpqb7Az0k069xRcwkeRh0po1AeqoO-rpq3qRyP_9PTZVgcolZxVP5mKzCDnVWYL--xfCXpvnDSGlxcF2xkjyg4bFEUVrSwFwlCxoKQpuAjJuQx1SCn2rrMqokEiPEBSi7PxdzGxtM63DVPb09a3vC-Bs9IyauJ1jcqqftS2RxDnZPrC1HSk6JMieeZVCERYsTE8jmtWp7UjUkCo5xT1DbcgNlO0cEtEOjnOU1_Sps0lilRJB0RsDCWaHPka40VCEa6ybplWo7sM52RJNNw8SWbMnPDlb1U4GCkxIxsiDdGVAeLQS8LyE1TA9OfSxDJIySXxhXYLLX_8dWo5sf1KKxA5HT46-ZkjbMGCdt_fG8HFsogIl4Q2oXZ_vMA9wgf9fU-zB0dN46b-84C3gEc8QKm |
link.rule.ids | 315,786,790,1382,27955,27956,46327,46751 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JTsMwEB0hEIIL-1JWH7imSho7SY-IAmUVQiBVXCLHGV8oDYJWAr6eGaeltICEEMrFB8fxkud5z_aMAfaCOMZQSUOzH0pPWiTM1Yz1ktBGWoc2j1w4hovLqHkrT1uq1b8OiH1hyvgQHwtujAw3XzPAeUF6DOW8MRnVW07nVd2uU5UI5RShXzFKG9fDWFJk98vQ4UHNIxs-dqzn25JGbdUXAjrKZ51BOpqH9qAp5TmU-2qvm1XN21iUx39q6wLM9Ymr2C__tEWYwM4STJdXWb5S6q5wqWU4uyoYZ20UfHJRFFY08VkJIseCyKZgLxMymrqXU2mPLKxJB4gPH0rOz9nc3sbDCtweHd4cNL3-lQ2ekZIXFK1vdFz3pbY5hllO1i9ESU-CMiGpZxKNpIkRY8uuWrU8rhsTB0Y7u5jZcBUmO0UH10Ggn-c0A-rMJJFMSCVliriFsaSclZ9lWIFgMDjpYxmZI_2saCSlqbv4nk2Zuu5KXyqwOxjFlGDEeyO6g0XvOQ3IUlMFk59zkM4jMpdEFVgrh3_4VVXzo7oKK6DcIP66OmnjuEGJjT--twszzZuL8_T85PJsE2bLM0W8PrQFk92nHm4TXepmOw4G7z-5BVQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LTwIxEJ4YjMaL7we-6MHrkn10HxyNiChKiJGEeNl0u9MLyhKBRP31Trs8BDUxxuxlDt1u29npfF87nQKcOWGIns8lzX7ILa6QbM6Vyoo8FQjhqTQw6RjumkG9zW86fmcc_6TPwuT5IaYLbtoyzHytDbyfqgUj1_uSQaVjaF7ZbDqVCU8u88BzNRGr3s9SSZHbzzOHO65FLnwhqufbmuZd1Rf8OQ9njT-qbUB30pM8DKVbHg2TsnxfSPL4P13dhPUxbGXn-X-2BUvY24aV_CLLN5IeMyPtQKOVaSt7QqbjFlmmWB0HPiNozAhqMn3GhFymGKVUW1_TamIBbHqCUpfXxczOxvMutGuXDxd1a3xhgyU518uJypYirNhcqBS9JCXf5yGnJ0IeEdGTkUBixIih0ge13DSsSBk6UhivmChvDwq9rIcHwNBOU5r_RCKjgEfEkRKfkIVUxJt9O0mwCM5EN3E_z8sRf-YznGQaLn3LJo_NcMWvRShNlBiTEemdEdHDbDSIHfLT1MDo5xLE8gjKRUER9nPtz77qu3ZQ8b0i-EaHv25OXL2qknD4x_dKsNqq1uLb62bjCNbygCK9OHQMheHLCE8IKw2TU2MEHxuqBAM |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Possible+role+of+Hes5+for+the+rostrocaudal+polarity+formation+of+the+tectum&rft.jtitle=Development%2C+growth+%26+differentiation&rft.au=Kimura%2C+Jun&rft.au=Katahira%2C+Tatsuya&rft.au=Araki%2C+Isato&rft.au=Nakamura%2C+Harukazu&rft.date=2004-06-01&rft.issn=0012-1592&rft.eissn=1440-169X&rft.volume=46&rft.issue=3&rft.spage=219&rft.epage=227&rft_id=info:doi/10.1111%2Fj.1440-169X.2004.00739.x&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_j_1440_169X_2004_00739_x |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-1592&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-1592&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-1592&client=summon |