MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT

• Published in: International forum of allergy & rhinology Vol. 15; no. 8; pp. 837 - 850
• Main Authors: Liu, Ruowu, Zhou, Jiao, Zhou, Jing, Liu, Feng, Liu, Yafeng, Meng, Juan, Ba, Luo, Xiao, Hengyi, Liu, Shixi, Zhang, Nan, Bachert, Claus, Du, Jintao
• Format: Journal Article
• Language: English
• Published: United States 01.08.2025
• Subjects: Adult; Cells, Cultured; Chronic Disease; CRSwNP; Cytokines - genetics; Cytokines - metabolism; Female; Humans; IL‐33; Interleukin-33 - metabolism; Male; mast cell; Mast Cells - immunology; Mast Cells - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR‐221‐3p; Nasal Polyps - genetics; Nasal Polyps - immunology; Nasal Polyps - metabolism; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Rhinitis - genetics; Rhinitis - immunology; Rhinitis - metabolism; Sinusitis - genetics; Sinusitis - immunology; Sinusitis - metabolism; mast cell; IL‐33; miR‐221‐3p; CRSwNP; KIT

ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of mi...