SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization

• Published in: Journal of thoracic oncology Vol. 15; no. 12; pp. 1823 - 1835
• Main Authors: Baine, Marina K, Hsieh, Min-Shu, Lai, W. Victoria, Egger, Jacklynn V., Jungbluth, Achim A., Daneshbod, Yahya, Beras, Amanda, Spencer, Rowanne, Lopardo, Jessica, Bodd, Francis, Montecalvo, Joseph, Sauter, Jennifer L., Chang, Jason C., Buonocore, Darren J., Travis, William D., Sen, Triparna, Poirier, John T., Rudin, Charles M., Rekhtman, Natasha
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2020; Copyright by the International Association for the Study of Lung Cancer
• Subjects: Adaptor Proteins, Signal Transducing; ASCL1; Basic Helix-Loop-Helix Transcription Factors; Humans; Immunohistochemistry; Lung Neoplasms; NEUROD1; Neuroendocrine; Octamer Transcription Factors; POU2F3; Prognosis; Repressor Proteins; Small Cell Lung Carcinoma; Transcription Factors; YAP-Signaling Proteins; YAP1; NEUROD1; YAP1; Small cell lung carcinoma; ASCL1; Neuroendocrine; POU2F3

Recent studies have identified subtypes of small cell lung carcinoma (SCLC) defined by the RNA expression of ASCL1, NEUROD1, POU2F3, and YAP1 transcriptional regulators. There are only limited data on the distribution of these markers at the protein level and associated pathologic characteristics in...